Caspase-3 inhibits the growth of breast cancer cells independent of protease activity

Journal of Cellular Physiology

Volumn 202, Issue 2, 2005, Pages 478-482

  Faraglia, Beatrice ^a   Bonsignore, Alessia ^b   Scaldaferri, Franco ^a   Boninsegna, Alma ^a   Cittadini, Achille ^a   Mancuso, Cesare ^b   Sgambato, Alessandro ^a  

^a Istituto di Patologia Generale   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; COMPLEMENTARY DNA; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; MUTANT PROTEIN; PROTEIN KINASE B; PROTEIN P27; PROTEINASE; STAUROSPORINE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASES; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FEMALE; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; STAUROSPORINE; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

MINK CELL FOCUS-FORMING VIRUS;

EID: 11144342325     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20149     Document Type: Article

References (27)

1. Chan SL, Mattson MP. 1999. Caspase and calpain substrates: Roles in synaptic plasticity and cell death. J Neurosci Res 58:167-190.
2. Cohen JJ, Dukes RC, Fadok VA, Sellins KS. 1992. Apoptosis and programmed cell death in immunity. Annu Rev Immunol 10:267-293.
3. Coney LR, Daniel PT, Sanborn D, Dhein J, Debatin KM, Krammer PH, Zurawski VR. 1994. Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression. Int J Cancer 4:562-567.
4. Devarajan E, Sahin AA, Cheri JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XM, Tora AD. 2002. Down-regulation of caspase-3 in breast cancer: A possible mechanism for chemoresistance. Oncogene 21:8843-8851.
5. Ellis RE, Yuan JY, Horvitz HR. 1991. Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698.
6. Friedrich K, Wieder T, Von Haefen C, Radetzki S, Janicke RU, Osthoff K, Dorken B, Daniel PT. 2001. Overexpression of caspace-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance. Oncogene 20:274927-274960.
7. Fu YG, Qu YJ, Wu KC, Zhai HH, Liu ZG, Fan DM. 2003. Apoptosis-inducing effect of recombinant caspase-3 expressed by constructed eukaryotic vector on gastric cancer cell line SCG 7901. World J Gastroenterol 9:1935-1939.
8. Gerard GI, Vousden KH. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411:342-349.
9. Glinsky GV, Glinsky W, Ivanova AB, Hueser CJ. 1997. Apoptosis and metastasis: Increased apoptosis resistance of metastatic cancer cells is associated with the profound deficiency of apoptosis execution mechanisms. Cancer Lett 115:185-193.
10. Grigoriev MY, Pozharissky KM, Hanson KP, Imyanitov EN, Zhivotovsky B. 2002. Expression of caspase-3 and -7 does not correlate with the expression of apoptosis in primary breast carcinomas. Cell Cycle 1:337-342.
11. Hadjiloucas I, Gilmore AP, Bundred NJ, Streuli CH. 2001. Assessment of apoptosis in human breast tissue using an antibody against the active form of caspase 3: Relation to tumour histopathological characteristics. Br J Cancer 85:1522-1526.
12. Janicke RU, Sprengart ML, Wati MR, Porter AG. 1998. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 273:9357-9360.
13. Kerr J, Wyllie A, Currie A. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
14. Kottke TJ, Blajeski AL, Meng XW, Svingen PA, Ruchaud S, Mesner PW, Boerner SA, Samejima K, Henriquez NV, Chilcote TJ, Lord J, Salmon M, Earnshaw WC, Kaufmann SH. 2002. Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells. J Biol Chem 277:804-815.
15. MacFarlane M, Cain K, Sun XM, Alnemri ES, Cohen GM. 1997. Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J Cell Biol 137:469-479.
16. Nakopoulou L, Alexandrou P, Stefanaki K, Panayotopoulou E, Lazaris AC, Davaris PS. 2001. Immunohistochemical expression of caspase-3 as an adverse indicator of the clinical outcome in human breast cancer. Pathobiology 69:266-273.
17. O'Donovan N, Crown J, Stunell H, Hill ADK, McDermott E, O'Higgins N, Duffy MJ. 2003. Caspace 3 in breast cancer. Clin Cancer Res 9: 738-742.
18. Ofir R, Seidman R, Rabinski T, Krup M, Yavelsky V, Weinstein Y, Wolfson M. 2002. Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent. Cell Death Differ 9:636-642.
19. Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray Cj Pickup DJ, Salvesen GS. 1996. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci USA 93:1972-1976.
20. Sgambato A, Doki Y, Schieren I, Weinstein IB. 1997. Effects of cyclin E overexpression on cell growth and response to transforming growth factor beta depend on cell context and p27Kip1 expression. Cell Growth Differ 8:393-405.
21. Sgambato A, Flamini G, Cittadini A, Weinstein IB. 1998a. Abnormalities in cell cycle control in cancer and their clinical implications. Tumori 84:421-433.
22. Sgambato A, Zhang YJ, Ciaparrone M, Soh JW, Cittadini A, Santella RM, Weinstein IB. 1998b. Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells. Cancer Res 58:3448-3454.
23. Sgambato A, Camerini A, Pani G, Cangiano R, Faraglia B, Bianchino G, De Bari B, Galeotti T, Cittadini A. 2003. Increased expression of cyclin E is associated with an increased resistance to doxorubicin in rat fibroblast. Br J Cancer 88:1956-1962.
24. Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL. 2002. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8:1145-1152.
25. Starcevic SL, Elferink C, Novak RF. 2001. Progressive resistance to apoptosis in a cell lineage model of human proliferative breast desease. J Natl Cancer Inst 93:776-782.
26. Vakkala M, Paakko P, Soini Y. 1999. Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion. Br J Cancer 81:592-599.
27. Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M. 2002. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 8:1136-1144.