N-acetyl-cysteine accelerates transfer of diabetes into non-obese diabetic scid mice

Diabetologia

Volumn 47, Issue 10, 2004, Pages 1803-1809

  Irie, J ^a   Shimada, A ^a   Oikawa, Y ^a   Shigihara, T ^a   Saruta, T ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Antioxidant; Non obese diabetic mouse; T helper cell type 1 2

Indexed keywords

ACETYLCYSTEINE; ANTIBODY; CD28 ANTIBODY; CD3 ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; MESSENGER RNA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL STIMULATION; CELL TRANSFER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DISEASE MODEL; DONOR; FEMALE; GENE EXPRESSION; HISTOLOGY; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MONONUCLEAR CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECIPIENT; RNA ANALYSIS; SPLEEN CELL;

ACETYLCYSTEINE; ANIMALS; CYTOKINES; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FEMALE; ISLETS OF LANGERHANS; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED NOD; MICE, SCID; POLYMERASE CHAIN REACTION; SPLEEN; TIME FACTORS;

EID: 11144308841     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1529-x     Document Type: Article

References (22)

1. Mathis D, Vence L, Benoist C (2001) β-cell death during progression to diabetes. Nature 414:792-798
2. 2 radicals in "autoimmune" diabetes. Immunol Cell Biol 67:85-87
3. Corbett JA, Mikhael A, Shimizu J et al. (1993) Nitric oxide production in islets from nonobese diabetic mice: amino-guanidine-sensitive and resistant stages in the immunological diabetic process. Proc Natl Acad Sci USA 90:8992-8995
4. Fukuda M, Ikegami H, Kawaguchi Y, Sano T, Ogihara T (1995) Antioxidant, probucol, can inhibit the generation of hydrogen peroxide in islet cells induced by macrophages and prevent islet cell destruction in NOD mice. Biochem Biophys Res Commun 209:953-958
5. Piganelli JD, Flores SC, Cruz C et al. (2002) A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 51:347-355
6. Meister A (1991) Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol Ther 51:155-194
7. Tepel M, Giet M van der, Schwarzfeld C, Laufer U, Liermann D, Zidek W (2000) Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343:180-184
8. Tepel M, Giet M van der, Statz M, Jankowski J, Zidek W (2003) The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure. Circulation 107:992-995
9. Eylar E, Rivera-Quinones C, Molina C, Baez I, Molina F, Mercado CM (1993) N-acetylcysteine enhances T cell functions and T cell growth in culture. Int Immunol 5:97-101
10. Puerto M, Guayerbas N, Victor VM, Fuente MD (2002) Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing. Pharmacol Biochem Behav 73:797-804
11. Murata Y, Amao M, Hamuro J (2003) Sequential conversion of the redox status of macrophages dictates the pathological progression of autoimmune diabetes. Eur J Immunol 33:1001-1011
12. Oikawa Y, Shimada A, Kasuga A et al. (2003) Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice. J Immunol 171:5865-5875
13. Overbergh L, Valckx D, Waer M, Mathieu C (1999) Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11:305-312
14. Kaneto H, Kajimoto Y, Miyagawa J et al. (1999) Beneficial effects of antioxidants in diabetes. Diabetes 48:2398-2406
15. Tarbell KV, Lee M, Ranheim E et al. (2002) CD4+ T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer. J Exp Med 196:481-492
16. Yim CY, Hibbs JB, McGregor JR, Galinsky RE, Samlowski WE (1994) Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immunol 152:5796-5805
17. Boon ACM, Vos AP, Graus YMF, Rimmelzwaan GF, Osterhaus ADME (2002) In vitro effect of bioactive compounds on influenza virus specific B- and T-cell responses. Scand J Immunol 55:24-32
18. Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C (1998) Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 95:3071-3076
19. Monick MM, Samavati L, Butler NS et al. (2003) Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J Immunol 171:5107-5115
20. Shimada A, Charlton B, Edwards CT, Fathman CG (1996) β-cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice. Diabetes 45:1063-1067
21. Berman MA, Sandborg CI, Wang Z et al. (1996) Decreased IL-4 production in new onset type 1 insulin-dependent diabetes mellitus. J Immunol 157:4690-4696
22. Delovitch TL, Singh B (1997) The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727-738