Growth hormone secretion in primary adrenal Cushing's syndrome is disorderly and inversely correlated with body mass index

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 1 51-1, 2005, Pages

  Van Aken, Maarten O ^a   Pereira, Alberto M ^a   Frölich, Marijke ^a   Romijn, Johannes A ^a   Pijl, Hanno ^a   Veldhuis, Johannes D ^b   Roelfsema, Ferdinand ^a,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAYO CLINIC   (United States)

^c Dept of Endocrinol and Metab Dis ^*  (Netherlands)

Author keywords

Adrenal adenoma; Cortisol; Entropy

Indexed keywords

HYDROCORTISONE;

ADRENAL CORTEX HYPERFUNCTION; ADRENAL HYPERPLASIA; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CUSHING SYNDROME; ENTROPY; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE RESPONSE; HUMAN; HYPERCORTISOLISM; HYPOGLYCEMIA; HYPOPHYSIS ADENOMA; MALE; METABOLIC ACTIVATION; PARACRINE SIGNALING; PRIORITY JOURNAL; PULSATILE FLOW;

ADENOMA; ADRENAL GLAND NEOPLASMS; ADULT; BODY MASS INDEX; CUSHING SYNDROME; EATING; ENTROPY; FEMALE; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED;

EID: 11144276452     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00317.2004     Document Type: Article

References (55)

1. Bergendahl M, Iranmanesh A, Pastor C, Evans WS, and Veldhuis JD. Homeostatic joint amplificafion of pulsatile and 24-hour rhythmic cortisol secretion by fasting stress in midluteal phase women: concurrent disruption of cortisol-growth hormone, cortisol-luteinizing hormone, and cortisol-leptin synchrony. J Clin Endocrinol Metab 85: 4028-4035, 2000.
2. Burguera B, Muruais C, Penalva A, Dieguez C, and Casanueva FF. Dual and selective actions of glucocorticoids upon basal and stimulated growth hormone release in man. Neuroendocrinology 51: 51-58, 1990.
3. Calabresi E, Ishikawa E, Bartolini L, Delitala G, Fanciulli G, Oliva O, Veldhuis JD, and Serio M. Somatostatin infusion suppresses GH secretory burst number and mass in normal men: a dual mechanism of inhibition. Am J Physiol Endocrinol Metab 270: E975-E979, 1996.
4. Carroll PV, Monson JP, Grossman AB, Besser GM, Plowman PN, Afshar F, and Savage MO. Successful treatment of childhood-onset Cushing's disease is associated with persistent reduction in growth hormone secretion. Clin Endocrinol (Oxf) 60: 169-174, 2004.
5. Chan JL, Heist K, DePaoli AM, Veldhuis JD, and Mantzoros CS. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 111: 1409-1421, 2003.
6. Charmandari E, Pincus SM, Mathews DR, Johnston A, Brook CGD, and Hindmarsh PC. Oral hydrocortisone administration in children with classic 21-hydroxylase deficiency leads to more synchronous joint growth hormone and cortisol secretion. J Clin Endocrinol Metab 87: 2238-2244, 2002.
7. Cizza G, Lotsikas AJ, Licinio J, Gold PW, and Chrousos GP. Plasma leptin levels do not change in patients with Cushing's disease shortly after correction of hypercortisolism. J Clin Endocrinol Metab 82: 2747-2750, 1997.
8. De Marinis L, Bianchi A, Mancini A, Gentilella R, Perrella M, Giampietro A, Porcelli T, Tilaro L, Fusco A, Valle D, and Tacchino RM. Growth hormone secretion and leptin in morbid obesity before and after biliopancreatic diversion: relationships with insulin and body composition. J Clin Endocrinol Metab 89: 174-180, 2004.
9. Fahry LS and Veldhuis JD. Joint pituitary-hypothalamic and intrahypothalamic autofeedback construct of pulsatile growth hormone secretion. Am J Physiol Regul Integr Comp Physiol 285: R1240-R1249, 2003.
10. Fahry LS and Veldhuis JD. Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator. Am J Physiol Regul Integr Comp Physiol 286: R1030-R1042, 2004.
11. Fife SK, Brogan RS, Giustina A, and Wehrenberg WB. Immunocytochemical and molecular analysis of the effects of glucocorticoid treatment on the hypothalamic-somatotropic axis in the rat. Neuroendocrinology 64: 131-138, 1996.
12. Friend K, Iranmanesh A, and Veldhuis JD. The orderliness of growth hormone (GH) release process and the mean mass of GH secreted per burst are highly conserved in individual men on successive days. J Clin Endocrinol Metab 81: 3746-3753, 1996.
13. Giustina A, Bossoni S, Bodini C, Ferrari C, Pizzocolo G, Scalvini T, Schettino M, and Wehrenberg WB. Pyridostigmine enhances even if it does not normalize the growth hormone responses to growth hormone-releasing hormone in patients with Cushing's disease. Horm Res 35: 99-103, 1991.
14. Giustina A and Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19: 717-797, 1998.
15. Groote Veldman R, Frölich M, Pincus SM, Veldhuis JD, and Roelfsema F. Hyperleptinemia in women with Cushing's disease is driven by high-amplitude pulsatile, but orderly and eurhythmic, leptin secretion. Eur J Endocrinol 144: 21-27, 2001.
16. Groote Veldman R, Frölich M, Pincus SM, Veldhuis JD, and Roelfsema F. Apparently complete restoration of normal daily adrenocorticotropin, cortisol, growth hormone, and prolactin secretory dynamics in adults with Cushing's disease after clinically successful transsphenoidal adenomectomy. J Clin Endocrinol Metab 85: 4039-4046, 2000.
17. Groote Veldman R, Frölich M, Pincus SM, Veldhuis JD, and Roelfsema F. Growth hormone and prolactin are secreted more irregularly in patients with Cushing's disease. Clin Endocrinol (Oxf) 52: 625-635, 2000.
18. Grottolli S, Gauna C, Tassone F, Aimaretti G, Corneli G, Wu Z, Strasburger CJ, Dieguez C, Cassanueva FF, Ghigo E, and Maccario M. Both fasting-induced leptin reduction and GH increase are blunted in Cushing's syndrome and in simple obesity. Clin Endocrinol (Oxf) 58: 220-228, 2003.
19. Hotta M, Shibasaki T, Masuda A, Imaki T, Sugino M, Demura H, Ling N, and Shizume K. Effect of human growth hormone-releasing hormone on GH secretion in Cushing's syndrome and non-endocrine disease patients treated with glucocorticoids. Life Sci 42: 979-984, 1988.
20. Hughes NR, Lissett CA, and Shalet SM. Growth hormone status following treatment for Cushing's syndrome. Clin Endocrinol (Oxf) 51: 61-66, 1999.
21. John CD, Christian HC, Morris JF, Flower RJ, Solito E, and Buckingham JC. Annexin 1 and the regulation of endocrine function. Trends Endocrinol Metab 15: 103-109, 2004.
22. Kok P, Buijs MM, Kok SW, van Ierssel IH, Frölich M, Roelfsema F, Voshol PJ, Meinders AE, and Pijl H. Acipimox enhances growth hormone secretion in obese women. Am J Physiol Regul Integr Comp Physiol 286: R693-R698, 2004.
23. Krieger DT and Glick SM. Growth hormone and cortisol responsiveness in Cushing's syndrome. Relation to a possible central nervous system etiology. Am J Med 52: 25-40, 1972.
24. Lacroix A, Ndiaye N, Tremblay J, and Hamet P. Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocr Rev 22: 75-110, 2001.
25. Lam KS, Lee MF, Tam SP, and Srivastava G. Gene expression of the receptor for growth hormone-releasing hormone is physiologically regulated by glucocorticoids and estrogen. Neuroendocrinology 63: 475-480, 1996.
26. Lam KS and Srivastava G. Gene expression of hypothalamic somatostatin and growth hormone-releasing hormone in dexamethasone-treated rats. Neuroendocrinology 66: 2-8, 1997.
27. Leal-Cerro A, Jimenez LM, Astorga R, Fernandez-Lopez I, Dieguez C, and Casanueva FF. Acute pharmacological reduction of plasma free fatty acids enhances the growth hormone (GH)-releasing hormone-mediated GH secretion in patients with Cushing's syndrome. J Clin Endocrinol Metab 82: 3165-3168, 1997.
28. Leal-Cerro A, Pereira JL, Garcia-Luna PP, Astorga R, Cordido F, Casanueva FF, and Dieguez C. Effect of enhancement of endogenous cholinergic tone with pyridostigmine on growth hormone (GH) responses to GH-releasing hormone in patients with Cushing's syndrome. Clin Endocrinol (Oxf) 33: 291-295, 1990.
29. Leal-Cerro A, Pumar A, Garcia-Garcia E, Dieguez C, and Casanueva FF. Inhibition of growth hormone release after combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome. Clin Endocrinol (Oxf) 41: 649-654, 1994.
30. Leal-Cerro A, Pumar A, Villamil F, Astorga R, Dieguez C, and Casanueva FF. Growth hormone releasing hormone priming increases growth hormone secretion in patients with Cushing's syndrome. Clin Endocrinol (Oxf) 38: 399-403, 1993.
31. Leal-Cerro A, Soto A, Martinez MA, Alvarez P, Isidro L, Casanueva FF, Dieguez C and Cordido F. Effect of withdrawal of somatostatin plus growth hormone (GH)-releasing hormone as a stimulus of GH secretion in Cushing's syndrome. Clin Endocrinol (Oxf) 57: 745-749, 2002.
32. Leal-Cerro A, Torres E, Soto A, Dios E, Deghenghi R, Arvat E, Ghigo E, Dieguez C, and Casanueva FF. Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotrophin and cortisol responses. Neuroendocrinology 76: 390-396, 2002.
33. Leal-Cerro A, Venegas E, Garcia-Pesquera F, Jimenez LM, Astorga R, Dieguez C, and Casanueva FF. Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary restriction in patients with Cushing's syndrome. Clin Endocrinol (Oxf) 48: 117-121, 1998.
34. Magiakou MA, Mastorakos G, Gomez MT, Rose SR, and Chrousos GH. Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure. J Clin Endocrinol Metab 78: 131-137, 1994.
35. Masuzaki H, Ogawa Y, Hosoda K, Miyawaki T, Hanaoka I, Hiraoka J, Yasuno A, Nishimura H, Yoshimasa Y, Nishi S, and Nakao K. Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome. J Clin Endocrinol Metab 82: 2542-2547, 1997.
36. Miller TL and Mayo KJ. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression. Endocrinology 138: 2458-2465, 1997.
37. Nolan LA, Kavanagh E, Lightman SL, and Levy A. Anterior pituitary cell population control: basal cell turnover and the effects of adrenalectomy and dexamethasone treatment. J Neuroendocrinol 10: 207-215, 1998.
38. Ozata M, Dieguez C, and Casanueva FF. The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: a study in human leptin deficiency patients. J Clin Endocrinol Metab 88: 312-316, 2003.
39. Philip JG, John CD, Cover PO, Morris JF, Christian HC, Flower RJ, and Buckingham JC. Opposing influences of glucocorticoids and interleukin-10 on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1. Br J Pharmacol 134: 887-895, 2001.
40. Pijl H, Langendonk JG, Burggraaf J, Frölich M, Cohen AF, Veldhuis JD, and Meinders AE. Altered neuroregulation of GH secretion in viscerally obese premenopausal women. J Clin Endocrinol Metab 86: 5509-5515, 2001.
41. Pincus SM. Approximate entropy as a measure of system complexity. Proc Natl Acad Sci USA 88: 2297-2301, 1991.
42. Pincus SM and Goldberger AL. Physiological time-series analysis: what does regularity quantify? Am J Physiol Heart Circ Physiol 266: H1643-H1656, 1994.
43. Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, and Veldhuis JD. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc Natl Acad Sci USA 93: 14100-14105, 1994.
44. Roelfsema F, Pincus SM, and Veldhuis JD. Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects. J Clin Endocrinol Metab 83: 688-692, 1998.
45. Smals AE, Pieters GF, Smals AG, Benraad TJ, and Kloppenborg PJ. Human pancreatic growth hormone releasing hormone fails to stimulate human growth hormone both in Cushing's disease and in Cushing's syndrome due to adrenal adenoma. Clin Endocrinol (Oxf) 24: 401-407, 1986.
46. Tamura H, Kamegai J, Sugihara H, Kineman RD, Frohman LA, and Wakabayashi I. Glucorticoids regulate pituitary growth hormone secretagogue receptor gene expression. J Neuroendocrinol 12: 481-485, 2000.
47. Taylor AD, Christian HC, Morris JF, Flower RJ, and Buckingham JC. Evidence from immunoneutralization and antisense studies that the inhibitory actions of glucocorticoids on growth hormone release in vitro require annexin 1 (lipocortin 1). Br J Pharmacol 131: 1309-1316, 2000.
48. Tzanela M, Karavitaki N, Stylianidou C, Tsagarakis S, and Thalassinos NC. Assessment of GH reserve before and after successful treatment of adult patients with Cushing's syndrome. Clin Endocrinol (Oxf) 60: 309-314, 2004.
49. Vahl N, Jorgensen JO, Skjaerback C, Veldhuis JD, Orskov H, and Christiansen J. Abdominal adiposity rather than age and sex predicts mass and regularity of GH secretion in healthy adults. Am J Physiol Endocrinol Metab 272: E1108-E1116, 1997.
50. Van den Berg G, Pincus SM, Frölich M, Veldhuis JD, and Roelfsema F. Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery. Eur J Endocrinol 138: 164-169, 1998.
51. Van den Berg G, Pincus SM, Veldhuis JD, Frölich M, and Roelfsema F. Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease. Eur J Endocrinol 136: 394-400, 1997.
52. Veldhuis JD, Carlson ML, and Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686-7690, 1987.
53. Veldhuis JD, Johnson ML, Faunt LM, and Seneta E. Assessing temporal coupling between two, or among three or more, neuroendocrine pulse trains: cross-correlation analysis, simulation methods, and conditional probability, testing. Methods Neurosci 20: 336-376, 1994.
54. Veldhuis JD, Johnson ML, Veldhuis OL, Straume M, and Pincus SM. Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion. Am J Physiol Regul Integr Comp Physiol 281: R1975-R1985, 2001.
55. Veldhuis JD, Straume M, Iranmanesh A, Mulligan T, Jaffe C, Barkan A, Johnson ML, and Pincus S. Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. Am J Physiol Regul Integr Comp Physiol 280: R721-R729, 2001.