Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6893-6901

  Gangjee, Aleem ^a   Zeng, Yibin ^a,d   McGuire, John J ^b   Mehraein, Farideh ^b   Kisliuk, Roy L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIAMINOPYRIMIDIN 4 ONE; ALPHA CHLOROMETHYL KETONE DERIVATIVE; AMINOPTERIN; BENZOIC ACID DERIVATIVE; DEOXYCYTIDINE; FOLIC ACID ANTAGONIST; FOLINIC ACID; FURO[2,3 D]PYRIMIDINE DERIVATIVE; HYPOXANTHINE; KETONE DERIVATIVE; METHYL 4 BROMOBENZOIC ACID DERIVATIVE; N [4 [3 (2 AMINO 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDIN 6 YL)PROPYL]BENZOYL]GLUTAMIC ACID; N [4 [3 (2,4 DIAMINOFURO[2,3 D]PYRIMIDIN 5 YL)PROPYL]BENZOYL]GLUTAMIC ACID; PEMETREXED; PYRIMIDINE DERIVATIVE; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; THYMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INHIBITION KINETICS; ISOMERIZATION; POLYMERIZATION; SAPONIFICATION; SEQUENCE ANALYSIS; SUBSTITUTION REACTION; TUMOR CELL CULTURE;

ANTIMETABOLITES, ANTINEOPLASTIC; FOLIC ACID ANTAGONISTS; HUMANS; PEPTIDE SYNTHASES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 11144231233     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040123k     Document Type: Article

References (33)

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