-
2
-
-
0023597504
-
J.; Sobrero, A
-
5975-5981; 1987.
-
McGuire, J. J.; Sobrero, A. F.; Hynes, J. B.; Bertino, J. R. Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells. Cancer Res. 47:5975-5981; 1987.
-
F.; Hynes, J. B.; Bertino, J. R. Mechanism of Action of 5,8-dideazaisofolic Acid and Other Quinazoline Antifols in Human Colon Carcinoma Cells. Cancer Res. 47
-
-
McGuire, J.1
-
7
-
-
0025820445
-
R.; Hughes, L
-
1594-1605; 1991.
-
Marsham, P. R.; Hughes, L. R.; Jackman, A. L.; Hayter, A. J.; Oldfield, J.; Wardleworth, J. M.; Bishop, J. A. M.; O'Connor, B. M.; Calvert, A. H. Quinazoline antifolate thymidylate synthase inhibitors: Heterocyclic benzoyl ring modifications. J. Med. Chem. 34:1594-1605; 1991.
-
R.; Jackman, A. L.; Hayter, A. J.; Oldfield, J.; Wardleworth, J. M.; Bishop, J. A. M.; O'Connor, B. M.; Calvert, A. H. Quinazoline Antifolate Thymidylate Synthase Inhibitors: Heterocyclic Benzoyl Ring Modifications. J. Med. Chem. 34
-
-
Marsham, P.1
-
8
-
-
0027477992
-
Banks, S.; Dev, i
-
1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res. 53: 810-818; 1993.
-
Duch, D.; Banks, S.; Dev, I. K.; Dickerson, S. H.; Ferone, R.; Heath, L. S.; Humphreys, J.; Knick, V.; Pendergast, W.; Singer, S.; Smith, G. K.; Waters, K.; Wilson, H. R. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res. 53: 810-818; 1993.
-
K.; Dickerson, S. H.; Ferone, R.; Heath, L. S.; Humphreys, J.; Knick, V.; Pendergast, W.; Singer, S.; Smith, G. K.; Waters, K.; Wilson, H. R. Biochemical and Cellular Pharmacology of
-
-
Duch, D.1
-
9
-
-
34648835773
-
Shetty, B.; Johnston, A.; Welsh, K.; Varney, M.; Deal, J.; Morse, C.; Soda, K
-
1992.
-
Webber, S.; Shetty, B.; Johnston, A.; Welsh, K.; Varney, M.; Deal, J.; Morse, C.; Soda, K. In vitro properties and antitumor activity of AG-331, a novel lipophilic thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res. 33:413; 1992.
-
In Vitro Properties and Antitumor Activity of AG-331, A Novel Lipophilic Thymidylate Synthase Inhibitor. Proc. Am. Assoc. Cancer Res. 33:413
-
-
Webber, S.1
-
10
-
-
0025997350
-
L.; Taylor, G
-
1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and i/i vivo: A new agent for clinical study. Cancer Res. 51: 5579-5586;1991.
-
Jackman, A. L.; Taylor, G. A.; Gibson, W.; Kimbell, R.; Brown, M.; Calvert, A. H.; Judson, I. R.; Hughes, L. R. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and i/i vivo: A new agent for clinical study. Cancer Res. 51: 5579-5586;1991.
-
A.; Gibson, W.; Kimbell, R.; Brown, M.; Calvert, A. H.; Judson, I. R.; Hughes, L. R. ICI D
-
-
Jackman, A.1
-
12
-
-
0028302718
-
J.; Bergoltz, v
-
2673-2679; 1994.
-
McGuire, J. J.; Bergoltz, V. V.; Heitzman, K. J.; Haue, W. H.; Russell, C. A.; Bolanowska, W. E.; Kotake, Y.; Haneda, T.; Nomura, H. Novel 6,5-fused-ring heterocyclic antifolates: Biochemical and biological characterization. Cancer Res. 54: 2673-2679; 1994.
-
V.; Heitzman, K. J.; Haue, W. H.; Russell, C. A.; Bolanowska, W. E.; Kotake, Y.; Haneda, T.; Nomura, H. Novel 6,5-fused-ring Heterocyclic Antifolates: Biochemical and Biological Characterization. Cancer Res. 54
-
-
McGuire, J.1
-
14
-
-
0001206491
-
F.; Lazarus, H.; Farber, S.; Uzman, B
-
1965.
-
Foley, G. F.; Lazarus, H.; Farber, S.; Uzman, B. G.; Boone, B. A.; McCarthy, R. E. Continuous culture of lymphoblasts from peripheral blood of a child with acute leukemia. Cancer 18:522-529; 1965.
-
G.; Boone, B. A.; McCarthy, R. E. Continuous Culture of Lymphoblasts from Peripheral Blood of A Child with Acute Leukemia. Cancer 18:522-529
-
-
Foley, G.1
-
15
-
-
0022007266
-
Srimatkandada, S.; Medina, W
-
1985.
-
Mini, E.; Srimatkandada, S.; Medina, W. D.; Moroson, B. A.; Carman, M. D.; Bertino, J. R. Molecular and karyological analysis of methotrexate-resistant and -sensitive human leukemic CCRF-CEM cells. Cancer Res. 45:317-325; 1985.
-
D.; Moroson, B. A.; Carman, M. D.; Bertino, J. R. Molecular and Karyological Analysis of Methotrexate-resistant and -Sensitive Human Leukemic CCRF-CEM Cells. Cancer Res. 45:317-325
-
-
Mini, E.1
-
16
-
-
0018912764
-
Lazarus, H.; Yuan, G
-
1980.
-
Rosowsky, A.; Lazarus, H.; Yuan, G. C.; Beltz, W. R.; Mangini, L.; Abelson, H. T.; Modest, E. J.; Frei, E., III. Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts. Biochem. Pharmacol. 29:648-652; 1980.
-
C.; Beltz, W. R.; Mangini, L.; Abelson, H. T.; Modest, E. J.; Frei, E., III. Effects of Methotrexate Esters and Other Lipophilic Antifolates on Methotrexate-resistant Human Leukemic Lymphoblasts. Biochem. Pharmacol. 29:648-652
-
-
Rosowsky, A.1
-
17
-
-
0025817134
-
E.; McGuire, J
-
6181-6187; 1991.
-
McCloskey, D. E.; McGuire, J. J.; Russell, C. A.; Rowan, B. G.; Bertino, J. R.; Pizzorno, G.; Mini, E. Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. J. Biol. Chem. 266:6181-6187; 1991.
-
J.; Russell, C. A.; Rowan, B. G.; Bertino, J. R.; Pizzorno, G.; Mini, E. Decreased Folylpolyglutamate Synthetase Activity As A Mechanism of Methotrexate Resistance in CCRF-CEM Human Leukemia Sublines. J. Biol. Chem. 266
-
-
McCloskey, D.1
-
19
-
-
0027745669
-
J.; Heitzman, K
-
1996-2003; 1993.
-
McGuire, J. J.; Heitzman, K. J.; Haile, W. H.; Russell, C. A.; McCloskey, D. E.; Piper, J. R. Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexateresistant CCRF-CEM human leukemia sublines. Leukemia 7: 1996-2003; 1993.
-
J.; Haile, W. H.; Russell, C. A.; McCloskey, D. E.; Piper, J. R. Cross-resistance Studies of Folylpolyglutamate Synthetase-deficient, Methotrexateresistant CCRF-CEM Human Leukemia Sublines. Leukemia 7
-
-
McGuire, J.1
-
20
-
-
0025318636
-
J.; Russell, C
-
1726-1731; 1990.
-
McGuire, J. J.; Russell, C. A.; Bolanowska, W. E.; Freitag, C. M.; Jones, C. S.; Kaiman, T. I. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the 7-carboxyl group. Cancer Res. 50:1726-1731; 1990.
-
A.; Bolanowska, W. E.; Freitag, C. M.; Jones, C. S.; Kaiman, T. I. Biochemical and Growth Inhibition Studies of Methotrexate and Aminopterin Analogues Containing A Tetrazole Ring in Place of the 7-carboxyl Group. Cancer Res. 50
-
-
McGuire, J.1
-
22
-
-
0028237440
-
M.; Webber, S.; Jackson, R
-
1994.
-
O'Connor, B. M.; Webber, S.; Jackson, R. C.; Galivan, J.; Rhee, M. S. Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor. Cancer Chemother. Pharmacol. 34:225-229; 1994.
-
C.; Galivan, J.; Rhee, M. S. Biological Activity of A Novel Rationally Designed Lipophilic Thymidylate Synthase Inhibitor. Cancer Chemother. Pharmacol. 34:225-229
-
-
O'Connor, B.1
-
23
-
-
0026492488
-
B.; Guimaraes, M
-
1694, a new quinazoline antifolate thymidylate synthase inhibitor. Cancer Res. 52:5900-5905; 1992.
-
Yin, M. B.; Guimaraes, M. A.; Zhang, Z. G.; Arredondo, M. A.; Rustum, Y. Time dependence of DNA lesions and growth inhibition by ICI D 1694, a new quinazoline antifolate thymidylate synthase inhibitor. Cancer Res. 52:5900-5905; 1992.
-
A.; Zhang, Z. G.; Arredondo, M. A.; Rustum, Y. Time Dependence of DNA Lesions and Growth Inhibition by ICI D
-
-
Yin, M.1
-
24
-
-
34648818705
-
R.; Heath, L
-
1843U89, a new antifolate thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res. 33:407; 1992.
-
Wilson, H. R.; Heath, L. S.; Knick, V. C.; Koszalla, G. W.; Ferone, R. In vivo antitumor activity of 1843U89, a new antifolate thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res. 33:407; 1992.
-
S.; Knick, V. C.; Koszalla, G. W.; Ferone, R. in Vivo Antitumor Activity of
-
-
Wilson, H.1
-
25
-
-
34648815593
-
D.; Waters, K
-
1843U89, at physiological thymidine concentrations. Proc. Am. Assoc. Cancer Res. 33: 407-407; 1992.
-
Banks, S. D.; Waters, K. A.; Barre, L. L.; Smith, G. K. Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor, 1843U89, at physiological thymidine concentrations. Proc. Am. Assoc. Cancer Res. 33: 407-407; 1992.
-
A.; Barre, L. L.; Smith, G. K. Destruction of WiDr Multicellular Tumor Spheroids with the Novel Thymidylate Synthase Inhibitor
-
-
Banks, S.1
-
26
-
-
0029031286
-
L.; Kelland, L
-
1694 (Tomudex) in one mouse and three human cell lines. Br. J. Cancer 71:914-924; 1995.
-
Jackman, A. L.; Kelland, L. R.; Kimbell, R.; Brown, M.; Gibson, W.; Aherne, G. W.; Hardcastle, A.; Boyle, F. T. Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. Br. J. Cancer 71:914-924; 1995.
-
R.; Kimbell, R.; Brown, M.; Gibson, W.; Aherne, G. W.; Hardcastle, A.; Boyle, F. T. Mechanisms of Acquired Resistance to the Quinazoline Thymidylate Synthase Inhibitor ZD
-
-
Jackman, A.1
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