Ribavirin monotherapy in patients with chronic hepatitis C: A retrospective study of 95 patients

Journal of Viral Hepatitis

Volumn 5, Issue 3, 1998, Pages 193-198

  Zoulim, F ^a,b   Haem, J ^a   Si Ahmed, S ^a   Chossegros, P ^a   Habersetzer, F ^a   Chevallier, M ^c   Bailly, F ^a   Trepo C ^a,b  

^a HÔTEL DIEU   (France)

^b INSERM   (France)

^c LMM Laboratoire Marcel Merieux   (France)

Author keywords

Chronic hepatitis; Hepatitis C virus; Ribavirin

Indexed keywords

ANTIVIRUS AGENT; RIBAVIRIN; VIRUS RNA;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG HYPERSENSITIVITY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER BIOPSY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT OUTCOME; VIRUS HEPATITIS;

ADULT; AGED; ANTIVIRAL AGENTS; FEMALE; HEPATITIS C, CHRONIC; HUMANS; LIVER; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RIBAVIRIN; TREATMENT OUTCOME;

EID: 0031831349     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1998.00099.x     Document Type: Article

References (23)

1. Hoofnagle JH, Di Bisceglie AM. The treatment of chronic viral hepatitis. N Engl J Med 1997; 336: 347-356.
2. Poynard T, Bedossa P, Chevallier M et al. A comparison of three interferon alfa-2b regimens for the long-term treatment of chronic non-A, non-B hepatitis. N Engl J Med 1995; 332: 1457-1462.
3. Fattovich G, Giustina G, Favarato S, Ruol A. A survey of adverse events in 11241 patients with chronic viral hepatitis treated with alfa interferon. J Hepatol 1996; 24: 38-47.
4. Tong MJ, El Farra NS, Reikes AR et al. Clinical outcomes after transfusion associated hepatitis C. N Engl J Med 1995; 332: 1463-1466.
5. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825-832.
6. Tsukuma H, Hiyama T, Tanaka S et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993; 328: 1797-1801.
7. Patterson JL, Fernandez-Larsson R. Molecular mechanisms of action of ribavirin. Rev Infect Dis 1990; 12: 1139-1146.
8. Zoulim F, Trépo C. Nucleoside analogs in the treatment of chronic viral hepatitis. Efficiency and complications. J Hepatol 1994; 21: 142-144.
9. Reichard O, Andersson J, Schvarcz R, Weiland O. Ribavirin treatment for chronic hepatitis C. Lancet 1991; 337: 1058-1061.
10. Di Bisceglie AM, Shindo M, Fong TL et al. A pilot study of ribavirin therapy for chronic hepatitis C. Hepatology 1992; 16: 649-654.
11. Camps J, Garcia N, Riezu-Boj JI, Civeira MP, Prieto J. Ribavirin in the treatment of chronic hepatitis C unresponsive to alfa interferon. J Hepatol 1993; 19: 408-412.
12. Di Bisceglie AM, Conjeevaram HS, Fried MW et al. Ribavirin as therapy for chronic hepatitis C. Ann Intern Med 1995; 12: 897-903.
13. Dusheiko G, Main J, Thomas H et al. Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study. J Hepatol 1996; 25: 591-598.
14. Bodenheimer HC, Lindsay KL, Davis GL, Lewis JH, Thung SN, Seeff LB. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: a multicenter trial. Hepatology 1997; 26: 473-477.
15. Ljungman P, Andersson J, Aschan J et al. Oral ribavirin for prevention of severe liver disease caused by hepatitis C virus during allogeneic bone marrow transplantation. Clin Infect Dis 1996; 23: 167-169.
16. Brillanti S, Garson J, Foli M et al. A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C. Gastroenterology 1994; 107: 812-817.
17. Lai M-Y, Kao J-H, Yang P-M et al. Long-term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C. Gastroenterology 1996; 111: 1307-1312.
18. Schalm SW, Hansen EH, Chemello L et al. Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C. Meta-analysis of individual patient data from European centers. J Hepatol 1997; 26: 961-966.
19. Trabaud MA, Bailly F, Si-Ahmed SN et al. Comparison of HCV RNA assays for the detection and quantification of hepatitis C virus RNA levels in serum of paatients with chronic hepatitis C treated with interferon. J Med Virol 1997; 52: 105-112.
20. Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-435.
21. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-1519.
22. Reichard O, Yun ZB, Sönnerborg A, Weiland O. Hepatitis C viral RNA titres in serum prior to, during, and after oral treatment with ribavirin for chronic hepatitis C. J Med Virol 1993; 41: 99-102.
23. Hoofnagle JH, Lau D, Conjeevaram H, Kleiner D, Di Bisceglie AMJ. Prolonged therapy of chronic hepatitis C with ribavirin. J Viral Hep 1996; 3: 247-252.