메뉴 건너뛰기




Volumn 8, Issue 6, 2004, Pages 589-593

Mechanisms of autoimmune hepatitis

Author keywords

Autoantibodies; Autoimmune hepatitis; Liver transplantation; Molecular mimicry

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIGEN; CD45 ANTIGEN; LIVER ANTIGEN; MICROSOME ANTIBODY; SMOOTH MUSCLE ANTIBODY; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 11144219748     PISSN: 13973142     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2004.00288.x     Document Type: Conference Paper
Times cited : (23)

References (48)
  • 1
    • 0026677933 scopus 로고
    • Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis
    • SENALDI G, PORTMANN B, MOWAT AP, MIELI-VERGANI G, VERGANI D. Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis. Arch Dis Child 1992: 67: 1447-1453.
    • (1992) Arch Dis Child , vol.67 , pp. 1447-1453
    • Senaldi, G.1    Portmann, B.2    Mowat, A.P.3    Mieli-Vergani, G.4    Vergani, D.5
  • 2
    • 0021848907 scopus 로고
    • HLA A1-B8-DR3 and suppressor cell function in first-degree relatives of patients with autoimmune chronic active hepatitis
    • NOURI-ARIA KT, DONALDSON PT, HEGARTY JE, EDDLESTON AL, WILLIAMS R. HLA A1-B8-DR3 and suppressor cell function in first-degree relatives of patients with autoimmune chronic active hepatitis. J Hepatol 1985: 1: 235-241.
    • (1985) J Hepatol , vol.1 , pp. 235-241
    • Nouri-Aria, K.T.1    Donaldson, P.T.2    Hegarty, J.E.3    Eddleston, A.L.4    Williams, R.5
  • 4
    • 0025904366 scopus 로고
    • Susceptibility to autoimmune chronic active hepatitis: Human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors
    • DONALDSON PT, DOHERTY DG, HAYLLAR KM, MCFARLANE IG, JOHNSON PJ, WILLIAMS R. Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors. Hepatology 1991: 13: 701-706.
    • (1991) Hepatology , vol.13 , pp. 701-706
    • Donaldson, P.T.1    Doherty, D.G.2    Hayllar, K.M.3    McFarlane, I.G.4    Johnson, P.J.5    Williams, R.6
  • 5
    • 0019919028 scopus 로고
    • Effect of corticosteroids on suppressor-cell activity in 'autoimmune' and viral chronic active hepatitis
    • NOURI-ARIA KT, HEGARTY JE, ALEXANDER GJ, EDDLESTON AL, WILLIAMS R. Effect of corticosteroids on suppressor-cell activity in 'autoimmune' and viral chronic active hepatitis. N Engl J Med 1982: 307: 1301-1304.
    • (1982) N Engl J Med , vol.307 , pp. 1301-1304
    • Nouri-Aria, K.T.1    Hegarty, J.E.2    Alexander, G.J.3    Eddleston, A.L.4    Williams, R.5
  • 7
    • 0025087972 scopus 로고
    • Class I and class II major histocompatibility complex antigen expression on hepatocytes: A study in children with liver disease
    • LOBO-YEO A, SENALDI G, PORTMANN B, MOWAT AP, MIELI-VERGANI G, VERGANI D. Class I and class II major histocompatibility complex antigen expression on hepatocytes: a study in children with liver disease. Hepatology 1990: 12: 224-232.
    • (1990) Hepatology , vol.12 , pp. 224-232
    • Lobo-Yeo, A.1    Senaldi, G.2    Portmann, B.3    Mowat, A.P.4    Mieli-Vergani, G.5    Vergani, D.6
  • 8
    • 0031666745 scopus 로고    scopus 로고
    • Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4(+) T cells
    • CHEN M, SHIRAI M, LIU Z, ARICHI T, TAKAHASHI H, NISHIOKA M. Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4(+) T cells. J Virol 1998: 72: 8301-8308.
    • (1998) J Virol , vol.72 , pp. 8301-8308
    • Chen, M.1    Shirai, M.2    Liu, Z.3    Arichi, T.4    Takahashi, H.5    Nishioka, M.6
  • 10
    • 0034077771 scopus 로고    scopus 로고
    • Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis
    • CZAJA AJ, DONALDSON PT. Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis. Immunol Rev 2000: 174: 250-259.
    • (2000) Immunol Rev , vol.174 , pp. 250-259
    • Czaja, A.J.1    Donaldson, P.T.2
  • 11
    • 2442667095 scopus 로고    scopus 로고
    • Different immunogenetic background in autoimmune hepatitis type 1, type and autoimmune sclerosing cholangitis
    • UNDERHILL J, MA Y, BOGDANOS DP, CHEESEMAN P, MIELI-VERGANI G, VERGANI D. Different immunogenetic background in autoimmune hepatitis type 1, type and autoimmune sclerosing cholangitis. J Hepatol 2002: 36(Suppl. 1): 156A.
    • (2002) J Hepatol , vol.36 , Issue.1 SUPPL.
    • Underhill, J.1    Ma, Y.2    Bogdanos, D.P.3    Cheeseman, P.4    Mieli-Vergani, G.5    Vergani, D.6
  • 12
    • 0008353836 scopus 로고
    • Gamma/delta+ T cell clones from liver biopsies of children with autoimmune chronic active hepatitis (aCAH) and primary sclerosing cholangitis (aPSC) are cytotoxic to human liver target cells
    • WEN L, PEAKMAN M, MOWAT AP, et al. gamma/delta+ T cell clones from liver biopsies of children with autoimmune chronic active hepatitis (aCAH) and primary sclerosing cholangitis (aPSC) are cytotoxic to human liver target cells. J Hepatol 1991: 13: S80.
    • (1991) J Hepatol , vol.13
    • Wen, L.1    Peakman, M.2    Mowat, A.P.3
  • 14
    • 0018147796 scopus 로고
    • Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis
    • JENSEN DM, MCFARLANE IG, PORTMANN BS, EDDLESTON AL, WILLIAMS R. Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. New Engl J Med 1978: 299: 1-7.
    • (1978) New Engl J Med , vol.299 , pp. 1-7
    • Jensen, D.M.1    McFarlane, I.G.2    Portmann, B.S.3    Eddleston, A.L.4    Williams, R.5
  • 15
    • 0023030129 scopus 로고
    • Serum autoantibodies reacting with the hepatic asialoglycoprotein receptor protein (hepatic lectin) in acute and chronic liver disorders
    • MCFARLANE BM, MCSORLEY CG, VERGANI D, MCFARLANE IG, WILLIAMS R. Serum autoantibodies reacting with the hepatic asialoglycoprotein receptor protein (hepatic lectin) in acute and chronic liver disorders. J Hepatol 1986: 3: 196-205.
    • (1986) J Hepatol , vol.3 , pp. 196-205
    • McFarlane, B.M.1    McSorley, C.G.2    Vergani, D.3    McFarlane, I.G.4    Williams, R.5
  • 16
    • 0031055029 scopus 로고    scopus 로고
    • Alcohol dehydrogenase: A target of humoral autoimmune response in liver disease
    • MA Y, GAKEN J, MCFARLANE BM, et al. Alcohol dehydrogenase: a target of humoral autoimmune response in liver disease. Gastroenterology 1997: 112: 483-492.
    • (1997) Gastroenterology , vol.112 , pp. 483-492
    • Ma, Y.1    Gaken, J.2    McFarlane, B.M.3
  • 17
    • 0023574027 scopus 로고
    • Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage
    • VERGANI D, MIELI-VERGANI G, MONDELLI M, PORTMANN B, EDDLESTON AL. Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage. Liver 1987: 7: 307-315.
    • (1987) Liver , vol.7 , pp. 307-315
    • Vergani, D.1    Mieli-Vergani, G.2    Mondelli, M.3    Portmann, B.4    Eddleston, A.L.5
  • 18
    • 0018289966 scopus 로고
    • Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis
    • MIELI-VERGANI G, VERGANI D, JENKINS PJ, et al. Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis. Clin Exp Immunol 1979: 38: 16-21.
    • (1979) Clin Exp Immunol , vol.38 , pp. 16-21
    • Mieli-Vergani, G.1    Vergani, D.2    Jenkins, P.J.3
  • 19
    • 0025675497 scopus 로고
    • T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
    • WEN L, PEAKMAN M, LOBO-YEO A, et al. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. Lancet 1990: 336: 1527-1530.
    • (1990) Lancet , vol.336 , pp. 1527-1530
    • Wen, L.1    Peakman, M.2    Lobo-Yeo, A.3
  • 20
    • 0025825932 scopus 로고
    • Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis
    • LOHR H, MANNS M, KYRIATSOULIS A, et al. Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis. Clin Exp Immunol 1991: 84: 297-302.
    • (1991) Clin Exp Immunol , vol.84 , pp. 297-302
    • Lohr, H.1    Manns, M.2    Kyriatsoulis, A.3
  • 21
    • 0026602517 scopus 로고
    • Liver-infiltrating T helper cells in autoimmune chronic active hepatitis stimulate the production of autoantibodies against the human asialoglycoprotein receptor in vitro
    • LOHR H, TREICHEL U, PORALLA T, MANNS M, MEYER ZUM BUSCHENFELDE KH. Liver-infiltrating T helper cells in autoimmune chronic active hepatitis stimulate the production of autoantibodies against the human asialoglycoprotein receptor in vitro. Clin Exp Immunol 1992: 88: 45-49.
    • (1992) Clin Exp Immunol , vol.88 , pp. 45-49
    • Lohr, H.1    Treichel, U.2    Poralla, T.3    Manns, M.4    Meyer Zum Buschenfelde, K.H.5
  • 22
    • 0023555290 scopus 로고
    • Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: A second type of 'autoimmune' hepatitis
    • HOMBERG JC, ABUAF N, BERNARD O, et al. Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of 'autoimmune' hepatitis. Hepatology 1987: 7: 1333-1339.
    • (1987) Hepatology , vol.7 , pp. 1333-1339
    • Homberg, J.C.1    Abuaf, N.2    Bernard, O.3
  • 23
    • 0023813850 scopus 로고
    • Anti-liver kidney microsome antibody recognizes a cytochrome P450 from the IID subfamily
    • GUEGUEN M, MEUNIER-ROTIVAL M, BERNARD O, ALVAREZ F. Anti-liver kidney microsome antibody recognizes a cytochrome P450 from the IID subfamily. J Exp Med 1988: 168: 801-806.
    • (1988) J Exp Med , vol.168 , pp. 801-806
    • Gueguen, M.1    Meunier-Rotival, M.2    Bernard, O.3    Alvarez, F.4
  • 24
    • 0034071317 scopus 로고    scopus 로고
    • Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane
    • MURATORI L, PAROLA M, RIPALTI A, et al. Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane. Gut 2000: 46: 553-561.
    • (2000) Gut , vol.46 , pp. 553-561
    • Muratori, L.1    Parola, M.2    Ripalti, A.3
  • 25
    • 0034023036 scopus 로고    scopus 로고
    • LKM antibody: Getting in some target practice
    • VERGANI D. LKM antibody: getting in some target practice. Gut 2000: 46: 449-450.
    • (2000) Gut , vol.46 , pp. 449-450
    • Vergani, D.1
  • 27
    • 0028148193 scopus 로고
    • Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C
    • MURATORI L, LENZI M, CATALETA M, et al. Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C. J Hepatol 1994: 21: 199-203.
    • (1994) J Hepatol , vol.21 , pp. 199-203
    • Muratori, L.1    Lenzi, M.2    Cataleta, M.3
  • 28
    • 0027251357 scopus 로고
    • Type II autoimmune hepatitis: The conundrum of cytochrome P450IID6
    • VERGANI D, MIELI-VERGANI G. Type II autoimmune hepatitis: the conundrum of cytochrome P450IID6 [editorial; comment]. Clin Exp Immunol 1993: 92: 367-368.
    • (1993) Clin Exp Immunol , vol.92 , pp. 367-368
    • Vergani, D.1    Mieli-Vergani, G.2
  • 29
    • 0027414305 scopus 로고
    • Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies (LKM1)
    • YAMAMOTO AM, CRESTEIL D, BONIFACE O, CLERC FF, ALVAREZ F. Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies (LKM1). Eur J Immunol 1993: 23: 1105-1111.
    • (1993) Eur J Immunol , vol.23 , pp. 1105-1111
    • Yamamoto, A.M.1    Cresteil, D.2    Boniface, O.3    Clerc, F.F.4    Alvarez, F.5
  • 30
    • 0037309189 scopus 로고    scopus 로고
    • Cytochrome P4502D6(193-212): A new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease
    • KERKAR N, CHOUDHURI K, MA Y, et al. Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease. J Immunol 2003: 170: 1481-1489.
    • (2003) J Immunol , vol.170 , pp. 1481-1489
    • Kerkar, N.1    Choudhuri, K.2    Ma, Y.3
  • 31
    • 0034926765 scopus 로고    scopus 로고
    • Molecular mimicry and autoimmune liver disease: Virtuous intentions, malign consequences
    • BOGDANOS DP, CHOUDHURI K, VERGANI D. Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences. Liver 2001: 21: 225-232.
    • (2001) Liver , vol.21 , pp. 225-232
    • Bogdanos, D.P.1    Choudhuri, K.2    Vergani, D.3
  • 32
    • 0025992973 scopus 로고
    • LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase
    • MANNS MP, GRIFFIN KJ, SULLIVAN KF, JOHNSON EF. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest 1991: 88: 1370-1378.
    • (1991) J Clin Invest , vol.88 , pp. 1370-1378
    • Manns, M.P.1    Griffin, K.J.2    Sullivan, K.F.3    Johnson, E.F.4
  • 33
    • 5444251837 scopus 로고    scopus 로고
    • Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA b51
    • BOGDANOS D, LENZI M, OKAMOTO M, et al. Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA b51. Int J Immunopathol Pharmacol 2004: 17: 83-92.
    • (2004) Int J Immunopathol Pharmacol , vol.17 , pp. 83-92
    • Bogdanos, D.1    Lenzi, M.2    Okamoto, M.3
  • 34
    • 0021884413 scopus 로고
    • Genetically determined low C4: A predisposing factor to autoimmune chronic active hepatitis
    • VERGANI D, WELLS L, LARCHER VF, et al. Genetically determined low C4: a predisposing factor to autoimmune chronic active hepatitis. Lancet 1985: 2: 294-298.
    • (1985) Lancet , vol.2 , pp. 294-298
    • Vergani, D.1    Wells, L.2    Larcher, V.F.3
  • 35
    • 0028080523 scopus 로고
    • Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis
    • DOHERTY DG, UNDERHILL JA, DONALDSON PT, et al. Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis. Autoimmunity 1994: 18: 243-249.
    • (1994) Autoimmunity , vol.18 , pp. 243-249
    • Doherty, D.G.1    Underhill, J.A.2    Donaldson, P.T.3
  • 36
    • 0029658198 scopus 로고    scopus 로고
    • Immunopathology or organ-specific autoimmunity as a consequence of virus infection
    • AICHELE P, BACHMANN MF, HENGARTNER H, ZINKERNAGEL RM. Immunopathology or organ-specific autoimmunity as a consequence of virus infection. Immunol Rev 1996: 152: 21-45.
    • (1996) Immunol Rev , vol.152 , pp. 21-45
    • Aichele, P.1    Bachmann, M.F.2    Hengartner, H.3    Zinkernagel, R.M.4
  • 37
    • 0344541095 scopus 로고    scopus 로고
    • De-novo autoimmune hepatitis after liver transplantation
    • KERKAR N, HADZIC N, DAVIES ET, et al. De-novo autoimmune hepatitis after liver transplantation. Lancet 1998: 351: 409-413.
    • (1998) Lancet , vol.351 , pp. 409-413
    • Kerkar, N.1    Hadzic, N.2    Davies, E.T.3
  • 38
    • 0034902744 scopus 로고    scopus 로고
    • Posttransplant immune hepatitis in pediatric liver transplant recipients: Incidence and maintenance therapy with azathioprine
    • ANDRIES S, CASAMAYOU L, SEMPOUX C, et al. Posttransplant immune hepatitis in pediatric liver transplant recipients: incidence and maintenance therapy with azathioprine. Transplantation 2001: 72: 267-272.
    • (2001) Transplantation , vol.72 , pp. 267-272
    • Andries, S.1    Casamayou, L.2    Sempoux, C.3
  • 40
    • 0034875566 scopus 로고    scopus 로고
    • Graft dysfunction mimicking autoimmune hepatitis following liver transplantation in adults
    • HENEGHAN MA, PORTMANN BC, NORRIS SM, et al. Graft dysfunction mimicking autoimmune hepatitis following liver transplantation in adults. Hepatology 2001: 34: 464-470.
    • (2001) Hepatology , vol.34 , pp. 464-470
    • Heneghan, M.A.1    Portmann, B.C.2    Norris, S.M.3
  • 41
    • 18244397464 scopus 로고    scopus 로고
    • Response to steroids in de novo autoimmune hepatitis after liver transplantation
    • SALCEDO M, VAQUERO J, BANARES R, et al. Response to steroids in de novo autoimmune hepatitis after liver transplantation. Hepatology 2002: 35: 349-356.
    • (2002) Hepatology , vol.35 , pp. 349-356
    • Salcedo, M.1    Vaquero, J.2    Banares, R.3
  • 42
    • 0023794047 scopus 로고
    • Abnormal differentiation of thymocytes in mice treated with cyclosporin A
    • GAO E, LO D, CHENEY R, KANAGAWA O, SPRENT J. Abnormal differentiation of thymocytes in mice treated with cyclosporin A. Nature 1988: 336: 176-179.
    • (1988) Nature , vol.336 , pp. 176-179
    • Gao, E.1    Lo, D.2    Cheney, R.3    Kanagawa, O.4    Sprent, J.5
  • 43
    • 0027209647 scopus 로고
    • Cyclosporin A-induced autoimmune disease in mice
    • BUCY PB, YAN XU X, LI J, HUANG GQ. Cyclosporin A-induced autoimmune disease in mice. J Immunol 1993: 151: 1039-1050.
    • (1993) J Immunol , vol.151 , pp. 1039-1050
    • Bucy, P.B.1    Yan Xu, X.2    Li, J.3    Huang, G.Q.4
  • 44
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • SAKAGUCHI S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000: 101: 455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 45
    • 0034093720 scopus 로고    scopus 로고
    • Role of genetic factors in organ-specific autoimmune diseases induced by manipulating the thymus or T cells, and not self-antigens
    • SAKAGUCHI S, SAKAGUCHI N. Role of genetic factors in organ-specific autoimmune diseases induced by manipulating the thymus or T cells, and not self-antigens. Rev Immunogenet 2000: 2: 147-153.
    • (2000) Rev Immunogenet , vol.2 , pp. 147-153
    • Sakaguchi, S.1    Sakaguchi, N.2
  • 46
    • 0033152075 scopus 로고    scopus 로고
    • Cyclosporin A-induced autologous graft-versus-host disease: A prototypical model of autoimmunity and active (dominant) tolerance coordinately induced by recent thymic emigrants
    • WU DY, GOLDSCHNEIDER I. Cyclosporin A-induced autologous graft-versus-host disease: a prototypical model of autoimmunity and active (dominant) tolerance coordinately induced by recent thymic emigrants. J Immunol 1999: 162: 6926-6933.
    • (1999) J Immunol , vol.162 , pp. 6926-6933
    • Wu, D.Y.1    Goldschneider, I.2
  • 47
    • 0031975636 scopus 로고    scopus 로고
    • Cyclosporin A-induced autoimmunity: The result of defective de novo T-cell development
    • DAMOISEAUX JG, VAN BREDA VRIESMAN PJ. Cyclosporin A-induced autoimmunity: the result of defective de novo T-cell development. Folia Biol 1998: 44: 1-9.
    • (1998) Folia Biol , vol.44 , pp. 1-9
    • Damoiseaux, J.G.1    Van Breda Vriesman, P.J.2
  • 48
    • 0035653063 scopus 로고    scopus 로고
    • Antibodies against glutathione S-transferase T1 (GSTT1) in patients with de novo immune hepatitis following liver transplantation
    • AGUILERA I, WICHMANN I, SOUSA JM, et al. Antibodies against glutathione S-transferase T1 (GSTT1) in patients with de novo immune hepatitis following liver transplantation. Clin Exp Immunol 2001: 126: 535-539.
    • (2001) Clin Exp Immunol , vol.126 , pp. 535-539
    • Aguilera, I.1    Wichmann, I.2    Sousa, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.