Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4+ T cells

Journal of Virology

Volumn 72, Issue 10, 1998, Pages 8301-8308

  Chen, Ming ^a,b   Shirai, Mutsunori ^a,c   Liu, Zijuan ^a   Arichi, Tatsumi ^a   Takahashi, Hidemi ^a,d   Nishioka, Mikio ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; EPSTEIN BARR VIRUS; GENETIC TRANSFECTION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LYMPHOBLASTOID CELL LINE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

EID: 0031666745     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.10.8301-8308.1998     Document Type: Article

References (60)

1. Alexander-Miller, M. A., G. R. Leggatt, and J. A. Berzofsky. 1996. Selective expansion of high-or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93:4102-4107.
2. Alexander-Miller, M. A., G. R. Leggatt, A. Sarin, and J. A. Berzofsky. 1996. Role of antigen, CD8, and CTL avidity in high dose antigen induction of apoptosis of effector CTL. J. Exp. Med. 184:485-492.
3. Alter, H. J., R. H. Purcell, J. W. Shih, J. C. Melolder, M. Houghton, and Q. L. Choo. 1989. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med. 321:1494-1500.
4. Arichi, T., et al. Unpublished data.
5. Bartido, S. M., S. Diment, and C. S. Reiss. 1995. Processing of a viral glycoprotein in the endoplasmic reticulum for class II presentation. Eur. J. Immunol. 25:2211-2219.
6. Bordignon, C., L. D. Notarangeo, N. Nobili, G. Ferrari, G. Casorati, P. Panina, E. Mazzolari, D. Maggioni, C. Rossi, P. Servida, A. G. Ugazio, and F. Mavilio. 1995. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science 270:470-475.
7. Botarelli, P., M. R. Brunetto, M. A. Minutello, P. Calvo, D. Unutmaz, A. J. Weiner, Q. L. Choo, J. R. Shuster, G. Kuo, F. Bonino, M. Houghton, and S. Abrignani. 1993. T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology 104:580-587.
8. Bukh, J., R. H. Miller, and R. H. Purcell. 1995. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin. Liver Dis. 15:41-63.
9. Calin-Laurens, V., F. Forquet, S. Lombard-Platet, P. Bertolino, I. Chretien, M. C. Trescol-Biemont, D. Gerlier, and C. Rabourdin-Combe. 1992. High efficiency of endogenous antigen presentation by MHC class II molecules. Int. Immunol. 4:1113-1121.
10. Cassell, D. J., and R. H. Schwartz. 1994. A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation. J. Exp. Med. 180:1829-1840.
11. Chen, M., M. Shirai, A. J. Czaja, K. Kurokohchi, T. Arichi, K. Arima, T. Kodama, and M. Nishioka. 1998. Characterization of antihistone antibodies in patients with type 1 autoimmune hepatitis. J. Gastroenterol. Hepatol. 13:483-489.
12. Chesnut, R. W., and K. B. Cease. 1986. Antigen presentation by B cells and its significance in T-B interactions. Adv. Immunol. 39:51-94.
13. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
14. Clevers, H. C., J. M. Versteegen, T. Logtenberg, F. H. Gmelig-Meyling, and R. E. Ballieux. 1985. Synergistic action of A23187 and phorbol ester on human B cell activation. J. Immunol. 135:3827-3830.
15. + T lymphocytes. J. Immunol. 148:1985-1992.
16. Denning, D., J. Lacerda, Y. Yan, C. Gasparetto, and R. J. O'Reilly. 1994. ICAM-1 (CD54) expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7. Cell Immunol. 156:414-423.
17. Di Bisceglie, A. M., Z. D. Goodman, K. G. Ishak, J. H. Hofnagle, J. J. Melpoder, and H. J. Alter. 1991. Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. Hepatology 14:969-974.
18. Diepolder, H. M., R. Zachoval, R. M. Hoffmann, E. A. Wierenga, T. Santantonio, M. C. Jung, D. Eichenlaub, and G. R. Pape. 1995. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346:1006-1007.
19. + T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J. Immunol. 155:45-57.
20. Earl, R. T., E. Mangiapane, E. E. Billett, and R. J. Mayer. 1987. A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with transplanted Sendai-viral envelope proteins in HTC cells. Biochem. J. 241:809-815.
21. Ferrari, C., A. Valli, L. Galati, A. Penna, P. Scaccaglia, T. Giuberti, C. Schianchi, G. Missale, M. G. Marin, and F. Fiaccadori. 1994 T cell response to structural and nonstructural hepatitis C virus antigen in persistent and self-limited hepatitis C virus infection. Hepatology 19:286-295.
22. Fleischer, B., H. Becht, and R. Rott. 1985. Recognition of viral antigens by human influenza A virus-specific T lymphocyte clones. J. Immunol. 135: 2800-2805.
23. Freeman, G. J., A. S. Freeman, J. M. Segil, G. Lee, J. F. Whitman, and L. M. Nadler. 1989. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143:2714-2722.
24. Germain, R. N., and L. R. Hendrix. 1991. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature 353:134-139.
25. Gimmi, C. D., G. J. Freeman, J. G. Gribben, K. Sugita, A. S. Freeman, C. Morimoto, and L. M. Nadler. 1991. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc. Natl. Acad. Sci. USA 88:6575-6579.
26. Guagliardi, L. E., B. Koppelman, J. S. Blum, M. S. Marks, P. Cresswell, and F. M. Brodsky. 1990. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature 343: 133-139.
27. Guery, J. C., and L. Adorini. 1995. Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells, J. Immunol. 154:536-544.
28. Harada, S., Y. Watanabe, K. Takeuchi, T. Suzuki, T. Katayama, Y. Takebe, I. Saito, and T. Miyamura. 1991. Expression of processed core protein of hepatitis C virus in mammalian cells. J. Virol. 65:3015-3021.
29. Harding, C. V., E. R. Unanue, J. W. Slot, A. L. Schwartz, and H. J. Gueze. 1990. Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing. Proc. Natl. Acad. Sci. USA 87:5553-5557.
30. Hijikata, M., N. Kato, Y. Ootsuyama, M. Nakagawa, and K. Shimotohno. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88:5547-5551.
31. + human cytotoxic T cell clones are restricted by class II HLA antigens. J. Immunol. 133:754-757.
32. Jin, Y. D., W. K. Shih, and I. Berkower. 1988. Human T cell response to the surface antigen of hepatitis B virus (HBsAg). J. Exp. Med. 168:293-306.
33. Kiyosawa, K., T. Sodeyama, E. Tanaka, Y. Gibo, K. Yoshizawa, Y. Nakano, S. Furuta, Y. Akahane, K. Nishioka, R. H. Purcell, and H. J. Alter. 1990. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12:671-675.
34. Lechmann, M., H. G. Ihlenfeldt, I. Braunschweiger, G. Giers, G. Jung, B. Matz, R. Kaiser, T. Sauerbruch, and U. Spengler. 1996. T-and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia. Hepatology 24:790-795.
35. Linsley, P. S., W. Brady, L. Grosmaire, A. Aruffo, N. K. Dameli, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173:721-730.
36. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045.
37. McCoy, K. L., J. Miller, M. Jenkins, F. Ronchese, R. N. Germain, and R. H. Schwartz. 1989. Diminished antigen processing by endosomal acidification mutant antigen-processing cells. J. Immunol. 143:29-38.
38. Missale, G., R. Bertoni, V. Lamonaca, A. Valli, M. Massari, C. Mori, M. G. Rumi, M. Houghton, F. Fiaccadori, and C. Ferrari. 1996. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin Investig 98: 706-714.
39. Mizuno, M., G. Yamada, T. Tanaka, K. Shimotohno, M. Takatani, and T. Tsuji. 1995. Virion-like structures in HeLa G cells transfected with the full-length sequence of the hepatitis C virus genome. Gastroenterology 109: 1933-1940.
40. Nuchtern, J. G., W. E. Biddison, and R. D. Klausner. 1990. Class II MHC molecules can use the endogenous pathway of antigen presentation. Nature 4:74-76.
41. Pecher, G., and O. J. Finn. 1996. Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells. Proc. Natl. Acad. Sci. USA 93:1699-1704.
42. Pihlajaniemi, T., T. Helaakoski, K. Tasanen, R. Myllyla, M. L. Huhtala, J. Koivu, and K. I. Kivirikko. 1987. Molecular cloning of the β-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene. EMBO J. 6:643-649.
43. Raff, M. C. 1970. Role of thymus-derived lymphocytes in the secondary humoral immune response in mice. Nature 226:1257-1259.
44. Ravaggi, A., N. Gioacchino, D. Primi, A. Albertini, M. Levrero, and E. Cariani. 1994. Intracellular localization of full-length and truncated hepatitis C virus core protein expressed in mammalian cells. J. Hepatol. 20:833-836.
45. Rehermann, B., K. M. Chang, J. G. McHutchison, R. Kokka, M. Houghton, and F. V. Chisari. 1996. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J. Clin. Investig. 98:1432-1440.
46. Rosa, D., S. Campagnoli, C. Moretto, E. Guenzi, L. Consens, M. Chin, C. Dong, A. J. Weiner, J. Y. N. Lau, Q. L. Choo, D. Chien, P. Pileri, M. Houghton, and S. Abrignani. 1996. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc. Natl. Acad. Sci. USA 93: 1759-1763.
47. Saito, T., H. Shinzawa, M. Kuboki, M. Ishibashi, H. Toda, Y. Okuyama, T. Nakamura, N. Yamada, H. Wakabayashi, H. Togashi, and T. Takahashi. 1994. A randomized, controlled trial of human lymphoblastoid interferon in patients with compensated type C cirrhosis. Am. J. Gastroenterol. 89:681-686.
48. Schwartz, R. H. 1984. The role of gene products of the major histocompatibility complex in T cell activation and cellular interactions, p. 385-392. In W. E. Paul (ed), Fundamental immunology. Raven Press, New York, N.Y.
49. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349-1356.
50. Sekaly, R. P., S. Jacobson, J. R. Richert, C. Tonnelle, H. F. McFarland, and E. O. Long. 1988. Antigen presentation to MHC class II-restricted measles virus-specific T-cell clones can occur in the absence of the invariant chain. Proc. Natl. Acad. Sci. USA 85:1209-1212.
51. Shirai, M., T. Arichi, M. Nishioka, T. Nomura, K. Ikeda, K. Kawanishi, V. H. Engelhard, S. M. Feinstone, and J. A. Berzofsky. 1995. CTL responses of HLA-2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1. J. Immunol. 154:2733-2742.
52. Shirai, M., H. Okada, M. Nishioka, T. Akatsuka, C. Wychowski, R. Houghten, C. D. Pendleton, S. M. Feinstone, and J. A. Berzofsky. 1994. An epitope in hepatitis C core region recognized by cytotoxic T cells in mice and humans. J. Virol. 68:3334-3342.
53. Sprent, J., and S. R. Webb. 1987. Function and specificity of T cell subsets in the mouse. Adv. Immunol. 41:39-133.
54. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
55. Sutkowski, N., M. L. Kuo, A. Varela-Echavarria, J. P. Dougherty, and Y. Ron. 1994. A murine model for B-lymphocyte somatic sene therapy. Proc. Natl. Acad. Sci. USA 91:8875-8879.
56. Takamizawa, A., C. Mori, I. Fuke, S. Manabe, S. Murakami, J. Fujita, E. Onishi, T. Andoh, I. Yoshida, and H. Okayama. 1991. Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 65:1105-1113.
57. Unanue, E. R. 1984. Antigen-presenting function of the macrophage. Annu. Rev. Immunol. 2:395-428.
58. Yewdell, J. W., and J. R. Bennink. 1990. The binary logic of antigen processing and presentation to T cells. Cell 62:203-206.
59. Yokochi, T., R. D. Holly, and E. A. Clark. 1982. B lymphoblastoid antigen (BB-1) expressed on EBV-activated B cell blasts, B lymphoblastoid cell lines and Burkitt's lymphomas. J. Immunol. 128:823-827.
60. Zinkernagel, R. M., and P. C. Doherty. 1979. MHC-reslricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function, and responsiveness. Adv. Immunol. 27:51-177.