Tumor-specific expression detected with the use of an expression vector driven by human telomerase reverse transcriptase gene promoter

Journal of Laboratory and Clinical Medicine

Volumn 144, Issue 6, 2004, Pages 302-306

  Yin, Jiajun ^a   Fu, Panfeng ^b   Wang, Xiaobo ^c   Jin, Gang ^d   Xiu, Ruijuan ^b  

^a China   (China)

^b Chinese Academy of Medical Sciences   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; GREEN FLUORESCENT PROTEIN; PLASMID VECTOR; PRIMER DNA; RESTRICTION ENDONUCLEASE; RETROVIRUS VECTOR; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; EXPRESSION VECTOR; FETUS; GENE ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN GENOME; LUNG FIBROBLAST; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REPORTER GENE;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CLONING, MOLECULAR; DNA-BINDING PROTEINS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS); RETROVIRIDAE; TELOMERASE; TRANS-ACTIVATION (GENETICS);

EID: 10944250096     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lab.2004.09.010     Document Type: Article

References (15)

1. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L. Ho Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
2. J.W. Shay, S. Bacchetti A survey of telomerase activity in human cancer Eur J Cancer 33 1997 787 791
3. M. Wick, D. Zubov, G. Hagen Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT) Gene 232 1999 97 106
4. S. Kondo, Y. Tanaka, Y. Kondo, Y. Ishizaka, M. Hitomi, T. Haqqi Retroviral transfer of CPP32beta gene into malignant gliomas in vitro and in vivo Cancer Res 58 1998 962 967
5. M. Meyerson, C.M. Counter, E.N. Eaton, L.W. Ellisen, P. Steiner, S.D. Caddle hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization Cell 90 1997 785 795
6. T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner Telomerase catalytic subunit homologs from fission yeast and human Science 277 1997 955 959
7. C. Ramachandran, H.B. Fonseca, P. Jhabvala, E.A. Escalon, S.J. Melnick Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line Cancer Lett 184 2002 1 6
8. E.H. Blackburn Structure and function of telomeres Nature 350 1991 569 573
9. N.W. Kim Clinical implications of telomerase in cancer Eur J Cancer 33 1997 781 786
10. S. Kyo, M. Inoue Complex regulatory mechanisms of telomerase activity in normal and cancer cells how can we apply them for cancer therapy? Oncogene 21 2002 688 697
11. A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin Extension of life-span by introduction of telomerase into normal human cells Science 279 1998 349 352
12. I. Horikawa, P.L. Cable, C. Afshari, J.C. Barrett Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene Cancer Res 59 1999 826 830
13. M. Takakura, S. Kyo, T. Kanaya, H. Hirano, J. Takeda, M. Yutsudo Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells Cancer Res 59 1999 551 557
14. E. Kim, J.H. Kim, H.Y. Shin, H. Lee, J.M. Yang, J. Kim Ad-mTERT-delta19, a conditional replication-competent adenovirus driven by the human telomerase promoter, selectively replicates in and elicits cytopathic effect in a cancer cell-specific manner Hum Gene Ther 14 2003 1415 1428
15. S.E. Holt, D.L. Aisner, J.W. Shay, W.E. Wright Lack of cell cycle regulation of telomerase activity in human cells Proc Natl Acad Sci U S A 94 1997 10687 10692