Fhit expression in human gastric adenomas and intramucosal carcinomas: Correlation with MIh1 expression and gastric phenotype

British Journal of Cancer

Volumn 90, Issue 3, 2004, Pages 672-677

  Kawaguchi, K ^a   Yashima, K ^a   Koda, M ^a   Tsutsumi, A ^a   Kitaoka, S ^a   Andachi, H ^a   Hosoda, A ^a   Kishimoto, Y ^a   Shiota, G ^a   Ito, H ^a   Murawaki, Y ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Endoscopic mucosal resection; Fhit; Gastric cancer; Immunohistochemistry; MIh1; Mucin phenotype

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; HYDROLASE; MLH1 PROTEIN, MAMMALIAN; PROTEIN MLH1; TUMOR PROTEIN;

ADENOMA; ADULT; AGED; ARTICLE; BASE MISPAIRING; BIOSYNTHESIS; CELL TRANSFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA REPAIR; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ADENOMA; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; STOMACH INTRAMUCOSAL CARCINOMA; STOMACH TUMOR; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOMA; AGED; BASE PAIR MISMATCH; CARRIER PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; STOMACH NEOPLASMS;

EID: 10744233552     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601601     Document Type: Article

References (45)

1. Andachi H, Yashima K, Koda M, Kawaguchi K, Kitamura A, Hosoda A, Kishimoto Y, Shiota G, Ito H, Makino M, Kaibara N, Kawasaki H, Murawaki Y (2002) Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. Br J Cancer 87: 441-445
2. Baffa R, Veronese ML, Santoro R, Mandes B, Palazzo JP, Rugge M, Santoro E, Croce CM, Huebner K (1998) Loss of FHIT expression in gastric carcinoma. Cancer Res 58: 4708-4714
3. Beak MJ, Rang H, Kim, SE, Park JH, Lee SJ, Paik YK, Kim H (2001) Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability. Br J Cancer 85: 1147-1152
4. Capuzzi D, Santoro E, Hauck WW, Kovatich AJ, Rosato FE, Baffa R, Huebner K, McCue PA (2000) Fhit expression in gastric adenocarcinonia. Cancer 88: 24-34
5. Caselli M, Marchisio M, Gaudio M, Saragoni L, Lanza G, Alvisi V, Bertagnolo V, Concu M, Capitani S, Caramelli E (2001) Fhit protein expression in human gastric cancer and related precancerous lesions. Oncol Rep 8: 1233-1237
6. Chong JM, Fukuyama M, Hayashi Y, Takizawa T, Koike M, Konishi M, Kikuchi-Yanoshita R, Miyaki M (1994) Microsatellite instability in the progression of gastric carcinoma. Cancer Res 54: 4595-4597
7. Croce CM, Sozzi G, Huebner K (1999) Role of FHIT in human cancer. J Clin Oncol 17: 1618-1624
8. Egashira Y, Shimoda T, Ikegami M (1999) Mucin histochemical analysis of minute gastric differentiated adenocarcinoma. Pathol Int 49: 55-61
9. Endo Y, Tamura G, Sakata K, Ohmura K, Watanabe E, Motoyama T (1999) Genetic analysis of differentiated-type adenocarcinomas of the stomach with gastric phenotype and intestinal phenotype (in Japanese with English abstract). Stomach Intestine 34: 539-544
10. Eshleman JR, Makowitz SD (1996) Mismatch repair defects in human carcinogenesis. Hum Mol Genet 5: 1489-1494
11. Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Nishizka S, James SP, Wilson KT, Herman JG, Meltzer SJ (2001) Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in human early gastric neoplasia. Oncogene 20: 329-335
12. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ (1999) Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 59: 1090-1095
13. Fong LYY, Fidanza V, Zanesi N, Lock LF, Siracusa LD, Mancini R, Siprashvili Z, Ottey M, Martin SE, Druck T, McCue PA, Croce CM, Huebner K (2000) Muir-Torre-like syndrome in Fhit-deficient mice. Pro Natl Acad Sci USA 97: 4742-4747
14. Gemma A, Hagiwara K, Ke Y, Burke LM, Khan MA, Nagasima M, Bennett WP, Harris CC (1997) FHIT mutations in human primary gastric cancer. Cancer 57: 1435-1437
15. Hao XP, Willis JE, Pretlow TG, Rao JS, MacLnnan GT, Talbot IC, Pretlow TP (2000) Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions. Cancer Res 60: 18-21
16. Hilgers W, Kern SE (1999) Molecular genetic basis of pancreatic adenocarcinoma. Genes Chromosomes Cancer 26: 1-12
17. Hilgers W, Koerkamp BG, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern SE (2000) Genomic FHIT analysis in RER+ and RER-adenocarcinomas of the pancreas. Genes Chromosomes Cancer 27: 239-243
18. Huiping C, Kristjansdottir S, Bergthorsson JT, Jonasson JG, Magnusson J, Egilsson V, Ingvarsson S (2002) High frequency of LOH, MSI and abnormal expression of FHIT in gastric cancer. Eur J Cancer 38: 728-735
19. Japanese Research Society for Gastric Cancer (1993) The General Rules for Gastric Cancer Study, 21st edn Tokyo: Kanehara Publication
20. Kabashima A, Yao T, Sugimachi K, Tsuneyoshi M (2002) Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinoma. Hum Pathol 33: 80-86
21. Kang GH, Shim YH, Ro JY (1999) Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. Lab Invest 79: 903-909
22. Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170
23. Kitamura A, Yashima K, Okamoto E, Andachi H, Hosoda A, Kishimoto Y, Shiota G, Ito H, Kaibara N, Kawasaki H (2001) Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis. Oncology 61: 205-211
24. Koseki K, Takizawa T, Koike M, Funata N, Hishima T, Sakoma T, Moriyama S, Okamoto H, Hayashi S, Iwasaki Y, Arai K. (1999) Subclassification of well differentiated gastric cancer with reference to biological behavior and malignancy, gastric type vs intestinal type, and papillary carcinoma vs tubular carcinoma. Stomach Intestine 34: 507-512
25. Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K (2000) Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 89: 724-732
26. Kruse R, Rutten A, Lamberti C, Hosseiny-Malayeri HR, Wang Y, Ruelfs C, Jungck M, Mathiak M, Ruzicka T, Hartschuh W, Bisceglia M, Friedl W, Propping P (1998) Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary non-polyposis colorectal cancer families defined by the Amsterdam criteria. Am J Hum Genet 63: 63-70
27. Lauren P (1965) The two main histological types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand A 64: 31-49
28. Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS, Ho JC (1999) hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 59: 159-164
29. Marcus VA, Madlensky L, Gryfe R, Kim H, So K, Millar A, Temple LKF, Hsieh E, Hiruki T, Narod S, Bapat BV, Gallinger S, Redston M (1999) Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. Am J Surg Pathol 23: 1248-1255
30. Mironov NM, Aguelon MA, Potapova GI, Omori Y, Gorbunov OV, Kulimenkov AA, Yamasaki H (1994) Alteration of (CA)n DNA repeats and tumor suppressor genes in human gastric cancer. Cancer Res 54: 41-44
31. Mori M, Mimori K, Masuda T, Yoshinaga K, Yamashita K, Matsuyama A, Inoue H (2001) Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit expression in colorectal carcinoma. Cancer Res 61: 7379-7382
32. Nakamura K, Sugano H, Takagi K (1968 Carcinoma of the stomach in incipient phase: Its histogenesis and histological appearance. Gann 59: 251-258
33. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, Macue P, Druck T, Croce CM, Huebner K (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma- associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84: 587-597
34. Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Flejou JF, Geboes K, Hattori T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H (2000) The Vienna classification of gastrointestinal epithelial neoplasia. Gut 47: 251-255
35. Skopelitou AS, Mitselou A, Katsanos KH, Alexopoulou V, Tsianos EV (2003) Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters. Eur J Gastroenterol Hepatol 15: 515-523
36. Sozzi G, Pastorino U, Moiraghi L, Tagliabue E, Pezzella F, Ghirelli C, Tornielli S, Sard L, Huebner K, Pierotti MA, Croce CM, Pilotti S (1998) Loss of Fhit function in lung cancer and preinvasive bronchial lesion. Cancer Res 58: 5032-5037
37. Strickler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR, Shibata D (1994) p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 54: 4750-4755
38. Suzuki H, Ito F, Toyama M, Kikuchi T, Kakiuchi H, Hinoda Y, Imai K (1999) Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. Int J Cancer 83: 309-313
39. Tajima Y, Shimoda T, Nakanishi Y, Yokoyama N, Tanaka T, Shimizu K, Saito T, Kawamura M, Kusano M, Kumagai K (2002) Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions. Oncology 61: 212-220
40. Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R (1997) Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines. Genes Chromosomes Cancer 20: 98-102
41. Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Terashima M, Eda Y, Satodate R (1996) Allelotype of adenoma and differentiated adenocarcinoma of the stomach. J Pathol 180: 371-377
42. Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, Moslein G, Baker SM, Liskay RM, Burgart LJ, Honchel R, Halling KC (1996) Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair gene. Cancer Res 56: 4836-4840
43. Tsukashita S, Kushima R, Bamba M, Sugihara H, Hattori T (2001) MUC gene expression and histogenesis of adenocarcinoma of the stomach. Int J Cancer 94: 166-170
44. Turner BC, Ottey M, Zimonjic DB, Potoczek M, Hauck WW, Pequignot E, Keck-Waggoner CL, Sevignani C, Aldaz CM, McCue PA, Palazzo J, Huebner K, Popescu NC (2002) The Fragile Histidine Triad/Common Chromosome Fragile Site 3B Locus and Repair-deficient Cancers. Cancer Res 62: 4054-4060
45. Yoshino T, Shimoda T, Saito A, Nakanishi Y, Tajima Y, Shirasu T, Miura S (1999) Macroscopic features of differentiated adenocarcinoma with gastric or intestinal phenotype expression in early gastric cancer (in Japanese with English abstract). Stomach Intestine 34: 513-525