Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas

Genes Chromosomes and Cancer

Volumn 27, Issue 3, 2000, Pages 239-243

  Hilgers, Werner ^a   Koerkamp, Bas Groot ^a   Geradts, Joseph ^b   Tang, David J ^a   Yeo, Charles J ^a   Hruban, Ralph H ^a   Kern, Scott E ^a,c  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE DELETION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; ANIMALS; DNA REPLICATION; GENES, TUMOR SUPPRESSOR; GENETIC MARKERS; HUMANS; LOSS OF HETEROZYGOSITY; MICE; MICE, NUDE; MICROSATELLITE REPEATS; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 0033985704     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(200003)27:3<239::AID-GCC3>3.0.CO;2-X     Document Type: Article

References (21)

1. Aaltonen LA, Peltomäki P, Leach KS, Sistonen P, Pylkkänen L, Mecklin J-P, Järvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A. 1993. Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816.
2. Baffa R, Veronese ML, Santoro R, Mandes B, Palazzo JP, Rugge M, Santoro E, Croce C, Huebner K. 1998. Loss of FHIT expression in gastric carcinoma. Cancer Res 58:4708-4714.
3. Boldog F, Gemmill RM, West J, Robinson M, Robinson L, Li E, Roche J, Todd S, Waggoner B, Lundstrom R, Jacobson J, Mullokandov MR, Klinger H, Drabkin HA. 1997. Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. Hum Molec Genet 6:193-203.
4. Brenner C, Pace HC, Garrison PN, Robinson A, Rosier AK, Liu XH, Blackburn GM, Croce C, Huebner K, Barnes LD. 1997. Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein. Protein Eng 10:1461-1463.
5. Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE. 1994. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8:27-31.
6. Druck T, Hadaczek P, Fu TB, Ohta M, Siprashvili Z, Baffa R, Negrini M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K. 1997. Structure and expression of the human FHIT gene in normal and tumor cells. Cancer Res 57:504-512.
7. +. Am J Pathol 152:1501-1507.
8. Greenspan DL, Connolly DC, Wu R, Lei R, Vogelstein JT, Kim YT, Mok JE, Munoz N, Bosch FX, Shah K, Cho KR. 1997. Loss of FHIT expression in cervical carcinoma cell lines and primary tumors. Cancer Res 57:4692-4698.
9. Hahn SA, Seymour AB, Hoque ATMS, Schutte M, da Costa LT, Redston MS, Caldas C, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. 1995. Allelotype of pancreatic adenocarcinoma using a xenograft model. Cancer Res 55:4670-4675.
10. Hahn SA, Hoque ATMS, Moskaluk CA, da Costa LT, Schutte M, Rozenblum E, Seymour AB, Weinstein CL, Yeo CJ, Hruban RH, Kern SE. 1996. Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res 56:490-494.
11. Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI. 1999. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer 24:48-55.
12. Le Beau MM, Drabkin H, Glover TW, Gemmill R, Rassool FV, McKeithan TW, Smith DI. 1998. An FHIT tumor suppressor gene? Genes Chromosomes Cancer 21:281-289.
13. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K. 1996. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84:587-597.
14. Seymour AB, Hruban RH, Redston M, Caldas C, Powell SM, Kinzler KW, Yee CJ, Kern SE. 1994. Allelotype of pancreatic adenocarcinoma. Cancer Res 54:2761-2764.
15. Shridhar R, Shridhar V, Wang X, Paradee W, Dugan M, Sarkar F, Wilke C, Glover TW, Vaitkevicius VK, Smith DI. 1996. Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors. Cancer Res 56:4347-4350.
16. Simon B, Bartsch D, Barth P, Prasnikar N, Munch K, Blum A, Arnold R, Goke B. 1998. Frequent abnormalities of the putative tumor suppressor gene FHIT-M 3p14.2 in pancreatic carcinoma cell lines. Cancer Res 58:1583-1587.
17. Sorio C, Baron A, Orlandini S, Zamboni G, Pederzoli P, Huebner K, Scarpa A. 1999. The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers. Cancer Res 59:1308-1314.
18. Sozzi G, Huebner K, Croce CM. 1998. FHIT in human cancer. Adv Cancer Res 74:141-166.
19. Su GH, Hruban RH, Bova GS, Goggins M, Bansal RK, Tang DT, Shekher MC, Entius MM, Yeo CJ, Kern SE. 1999. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 154:1835-1840.
20. Thiagalingam S, Lisitsyn NA, Hamaguchi M, Wigler MH, Willson JK, Markowitz SD, Leach FS, Kinzler KW, Vogelstein B. 1996. Evaluation of the FHIT gene in colorectal cancers. Cancer Res 56:2936-2939.
21. Wang L, Darling J, Zhang JS, Qian CP, Hartmann L, Conover C, Jenkins R, Smith DI. 1998. Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact. Oncogene 16:635-642.