Intronic Deletion Affecting a Negative Regulatory Region of TP73 is Related to Breast and Colorectal Carcinomas

Genes Chromosomes and Cancer

Volumn 39, Issue 3, 2004, Pages 257-262

  Peña, Cristina ^a   Garcia, Jose M ^a   Dominguez, Gemma ^a   Silva, Javier ^a   Garcia, Vanesa ^a   Carcereny, Enric ^a   Vargas, Javier ^b   Provencio, Mariano ^a   España, Pilar ^a   Bonilla, Felix ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b HOSPITAL UNIVERSITARIO SANTA CRISTINA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; DNA; GENE PRODUCT; GUANINE; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PROTEIN P73; THYMINE; TP73L PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BREAST CARCINOMA; BREAST TUMOR; COLORECTAL CARCINOMA; COLORECTAL TUMOR; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE MUTATION; GENE SILENCING; GENETICS; HETEROZYGOSITY; HETEROZYGOSITY LOSS; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; INTRON; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; BREAST NEOPLASMS; COLORECTAL NEOPLASMS; DNA; DNA, NEOPLASM; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 10744230672     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10322     Document Type: Article

References (23)

1. Dominguez G, Silva JM, Silva J, Garcia JM, Sanchez A, Navarro A, Gallego I, Provencio M, España P, Bonilla F. 2001. Wild type p73 overexpression and high-grade malignancy in breast cancer. Breast Cancer Res Tr 66:183-190.
2. Fillippovich I, Sorokina N, Gatei M, Haupt Y, Hobson K, Moallem E, Spring K, Mould M, McGuckin MA, Lavin MF, Khanna KK. 2001. Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. Oncogene 20:514-522.
3. Fontemaggi G, Gurtner A, Strano S, Higashi Y, Sacchi A, Piaggio G, Blandino G. 2001. The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation. Mol Cell Biol 21:8461-8470.
4. Higashino F, Pipas JM, Shenk T. 1998. Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73. Proc Natl Acad Sci USA 95:15683-15687.
5. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S. 2002. Possible oncogenic potential of Anp73: a newly identified isoform of human p73. Cancer Res 62:636-641.
6. Jost CA, Marin, MC, Kaelin WG. 1997. P73 is a human p53-related protein that can induce apoptosis. Nature 389:191-194.
7. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. 1997. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90:809-819.
8. Knight JC, Keating BJ, Rocett KA, Kwiatkowski DP. 2003. In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat Genet 33:469-475.
9. Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D, Kaellin WC Jr. 1998. Viral Oncoproteins discriminate between p53 and p53 homolog p73. Mol Cell Biol 18:6316-6324.
10. Martinez-Delgado B, Melendez B, Cuadros M, Jose Garcia M. Nomdedeu J, Rivas C, Fernandez-Piqueras J, Benitez J. 2002. Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas. Int J Cancer 102:15-19.
11. Ng SW, Yiu GK, Liu Y, Huang LW, Palnati M, Jun SH, Berkowitz RS, Mok SC. 2000. Analysis of p73 in human borderline and invasive ovarian tumor. Oncogene 19:1885-1890.
12. Nomoto S, Haruki N, Kondo M, Konishi H, Takahashi T, Takahashi T, Takahashi T. 1998. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.3 in human lung cancers. Cancer Res 58:1380-1383.
13. Oto M, Miyake S, Yuasa Y. 1993. Optimization of nonradioisotopic single strand conformation polymorphism analysis with a conventional minislab gel electrophoresis apparatus. Ann Biochem 213:19-22.
14. Postigo AA, Dean DC. 1997. ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation. EMBO J 16:3935-3943.
15. Postigo AA, Ward E, Skeath JB, Dean DC. 1999. Zfh-1, the Drosophila homolog of ZEB, is a transcriptional repressor that regulates somatic myogenesis. Mol Cell Biol 19:7255-7263.
16. Sayan AE, Sayan BS, Findikli N, Ozturk M. 2001. Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells. Oncogene 20:5111-5117.
17. Stiewe T, Putzer BM. 2002. Role of p73 in malignancy: tumor suppressor or oncogene? Cell Death Differ 9:237-245.
18. Stiewe T, Zimmermann, Frilling A, Esche H, Putzer BM. 2002. Transactivation-deficient ATA-p73 acts as an oncogene. Cancer Res 62:3598-3602.
19. Tsao H, Zhang X, Majewski P, Haluska FG. 1999. Mutational and expression analysis of the p73 gene in melanoma cell lines. Cancer Res 59:172-174.
20. Yang A, Kaghad M, Wang Y, Gillet E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F. 1998. P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2:305-316.
21. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D. 2000. P73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 2:99-103.
22. Zaika AI, Kovalev S, Marchenko ND, Moll UM. 1999. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res 59:3257-3263.
23. Zhu J, Jiang J, Zhou W, Chen X. 1998. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res 58:5061-5065.