Functional defects of dendritic cells in patients with CD40 deficiency

Blood

Volumn 102, Issue 12, 2003, Pages 4099-4106

  Fontana, Stefania ^b   Moratto, Daniele ^b   Mangal, Surinder ^b   De Francesco, Maria ^b   Vermi, William ^b   Ferrari, Simona ^b   Facchetti, Fabio ^b   Kutukculer, Necil ^b   Fiorini, Claudia ^b   Duse, Marzia ^b   Das, Pranab K ^b   Notarangelo, Luigi D ^b   Plebani, Alessandro ^b   Badolato, Raffaele ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CD83 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CASE REPORT; CD40 GENE; CELL DIFFERENTIATION; CELL MATURATION; CHILD; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; GENE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HYPERIMMUNOGLOBULINEMIA M; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; MONOCYTE; OPPORTUNISTIC INFECTION; PINOCYTOSIS; PLASMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 10744228754     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-04-1244     Document Type: Article

References (34)

1. Levy J, Espanol-Boren T, Thomas C, et al. Clinical spectrum of X-linked hyper-IgM syndrome. J Pediatr. 1997;131:47-54.
2. Fuleihan RL. The hyper IgM syndrome. Curr Allergy Asthma Rep. 2001;1:445-450.
3. Durandy A. Terminal defects of B lymphocyte differentiation. Curr Opin Allergy Clin Immunol. 2001;1:519-524.
4. Ferrari S, Giliani S, Insalaco A, et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001;98:12614-12619.
5. Kutukculer N, Moratto D, Aydinok Y, et al. Disseminated Cryptosporidium infection in an infant with hyper-IgM syndrome due to CD40 deficiency. J. Pediatr. 2003;142:194-196.
6. Revy P, Muto T, Levy Y, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell. 2000;102:565-575.
7. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol. 2000;18:767-811.
8. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106:255-258.
9. Cella M, Facchetti F, Lanzavecchia A, Colonna M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat Immunol. 2000;1:305-310.
10. Siegal FP, Kadowaki N, Shodell M, etal. The nature of the principal type 1 interferon-producing cells in human blood. Science. 1999;284:1835-1837.
11. Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol. 1997;9:10-16.
12. Jain A, Atkinson TP, Lipsky PE, et al. Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome. J Clin Invest. 1999;103:1151-1158.
13. Revy P, Geissmann F, Debre M, Fischer A, Durandy A. Normal CD40-mediated activation of monocytes and dendritic cells from patients with hyper-IgM syndrome due to a CD40 pathway defect in B cells. Eur J Immunol. 1998;28:3648-3654.
14. Lobo FM, Scholl PR, Fuleihan RL. CD40 ligand-deficient T cells from X-linked hyper-IgM syndrome carriers have intrinsic priming capability. J Immunol. 2002;168:1473-1478.
15. Caux C, Massacrier C, Vanbervliet B, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med. 1994;180:1263-1272.
16. DiSanto JP, Bonnefoy JY, Gauchat JF, Fischer A, de Saint BG. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. Nature. 1993;361:541-543.
17. Soumelis V, Scott I, Gheyas F, et al. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood. 2001;98:906-912.
18. Badolato R, Wang JM, Murphy WJ, et al. Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J Exp Med. 1994;180:203-209.
19. Fiorini M, Vermi W, Facchetti F, et al. Defective migration of monocyte-derived dendritic cells in LAD-1 immunodeficiency. J Leuk Biol. 2002;72:650-656.
20. Allavena P, Badolato R, Facchetti F, et al. Monocytes from Wiskott-Aldrich patients differentiate in functional mature dendritic cells with a defect in CD83 expression. Eur J Immunol. 2001;31:3413-3421.
21. Saint-Vis B, Vincent J, Vandenabeele S, et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity. 1998;9:325-336.
22. Allavena P, Piemonti L, Longoni D, et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol. 1996;28:359-369.
23. Cella M, Scheidegger D, Palmer-Lehmann K, et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 1996;184:747-752.
24. Gerosa F, Baldani-Guerra B, Nisii C, et al. Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med. 2002;195:327-333.
25. Chehimi J, Campbell DE, Azzoni L, et al. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J Immunol. 2002;168:4796-4801.
26. Hacker H, Vabulas RM, Takeuchi O, et al. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med. 2000;192:595-600.
27. Kadowaki N, Ho S, Antonenko S, et al. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J Exp Med. 2001;194:863-869.
28. Luft T, Jefford M, Luetjens P, et al. IL-1 beta enhances CD40 ligand-mediated cytokine secretion by human dendritic cells (DC): a mechanism for T cell-independent DC activation. J Immunol. 2002;168:713-722.
29. Trevejo JM, Marino MW, Philpott N, et al. TNF-alpha-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proc Natl Acad Sci U S A. 2001;98:12162-12167.
30. Ameratunga R, Lederman HM, Sullivan KE, et al. Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome. J Pediatr. 1997;131:147-150.
31. Hayward AR, Levy J, Facchetti F, et al. Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM. J Immunol. 1997;158:977-983.
32. Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol. 2001;166:4312-4318.
33. de Waal MR, Haanen J, Spits H, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med. 1991;174:915-924.
34. Gao JX, Madrenas J, Zeng W, et al. CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection. Immunology. 1999;98:159-170.