Comprehensive mammalian genetics: History and future prospects of gene trapping in the mouse

International Journal of Developmental Biology

Volumn 42, Issue 7, 1998, Pages 1025-1036

  Zambrowicz, Brian P ^a   Friedrich, Glenn A ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

Gene trapping; Genomics; Mouse embryonic stem cells; Mutagenesis

Indexed keywords

GENE PRODUCT;

ANIMAL GENETICS; ARTICLE; EMBRYO CELL; GENE INSERTION; GENE LIBRARY; GENE MUTATION; GENE TARGETING; GENOME; MAMMAL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DATABASES, FACTUAL; GENE EXPRESSION; GENE LIBRARY; GENES, REPORTER; GENETIC TECHNIQUES; HISTORY, 20TH CENTURY; HUMANS; MICE; MUTAGENESIS, INSERTIONAL; STEM CELLS;

EID: 0031796893     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. ALLEN, N.D., CRAN, D.G , BARTON, S.C., HETTLE, S , REIK, W and SURANI, M A. (1988). Transgenes as probes for active chromosomal domains in mouse development Nature. 333. 852-855
2. BAKER, R.K., HAENDEL, M.A., SWANSON, B.J., SHAMBAUGH, J C., MICALES, B K. and LYONS, G.E (1997). In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse Dev Biol 185 201-214.
3. BASSETT, D.E , JR., BASRAI, M.A., CONNELLY, C., HYLAND, K.M., KITAGAWA, K., MAYER, M.L., MORROW, D M., PAGE, A.M., RESTO, V A , SKIBBENS, R V. and MIETER, P (1996). Exploiting the complete yeast genome sequence. Curr. Opin. Genet Dev. 6 763-766
4. BELLEN, H J., O'KANE, C.J., WILSON, C., GROSSNIKLAUS, U., PEARSON, R K. and GEHRING, W.J. (1989). P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev. 3: 1288-1300.
5. BIER, E., VAESSIN, H., SHEPHERD, S., LEE, K , MCCALL, K., BARBEL, S., ACKERMAN, L., CARRETTO, R., UEMURA, T., GRELL, E , JAN, L Y. and JAN, Y N. (1989). Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 3: 1273-1287
6. BRADLEY, A. (1993). Site-directed mutagenesis in the mouse. Recent Prog. Horm. Res. 48: 237-251.
7. BROWN, S.D.M. and PETERS, J. (1996). Combining mutagenesis and genomics in the mouse-closing the phenotype gap. Trends Genet 12: 433-435.
8. CAMPBELL, P (1996). Intelligent drug design. Nature 384 (Suppl.): 1-5.
9. CARLSON, J (1993). Molecular genetics of Drosophila olfaction Ciba Found. Symp. 179: 162-166.
10. CHANG, W., HUBBARD, C., FRIEDEL, C. and RULEY, E. (1993). Enrichment of insertional mutants following retrovirus gene trap selection. Virology 193. 737-747.
11. CHEN, Z , FRIEDRICH, G.A. and SORIANO, P. (1994). Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice Genes Dev. 2293-2301
12. CHOWDHURY, K., BONALDO, P., TORRES, M., STOYKOVA, A and GRUSS, P. (1997) Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res 25. 1531-1536.
13. DEGREGORI, J., RUSS, A , VON MELCHNER, H , RAYBURN, H., PRIYARANJAN, P, JENKINS, N.A., COPELAND, N.G. and RULEY, H.E. (1994). A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 8: 265-276.
14. DENG, J.M. and BEHRINGER, R.R. (1995). An insertional mutation in the BTF3 transcription factor gene leads to an early postimplantation lethality in mice. Transgenic Res. 4: 264-269.
15. DOOLITTLE, R F. (1994). Protein sequence comparisons searching databases and aligning sequences. Curr. Biol. 5: 24-28.
16. EVANS, M.J., CARLTON, M B.L. and RUSS, A.P. (1997). Gene trapping and functional genomics. Trends Genet. 13: 370-374.
17. FAZELI, A., DICKINSON, S.L , HERMISTON, M.L , TIGHE, R.V., STEEN, R.G., SMALL, C.G., STOECKLI, E.T., KEINO-MASU, K., MASU, M., RAYBURN, H., SIMONS, J , BRONSON, R.T., GORDON, J.I , TESSIER-LAVIGNE, M. and WEINBERG, R A. (1997). Phenotype of mice lacking functional deleted in colorectal cancer (DCC) gene Nature 386: 796-804.
18. FIELDS, C. (1992) Data exchange and inter-database communication in genome projects. Trends Biotechnol 10. 58-61.
19. FIELDS, S. (1997). The future is function. Nature Genet. 15: 325-327.
20. FIELDS, S. and STERNGLANZ, R (1994). The two-hybrid system: an assay for protein-protein interactions. Trends Genet 10: 286-292.
21. FORRESTER, L.M., NAGY, A , SAM, M., WATT, A., STEVENSON, L , BERNSTEIN, A., JOYNER, A L and WURST, W. (1996). An induction gene trap screen in embryonic stem cells: identification of genes that respond to retinoic acid in vitro Proc. Natl Acad Sci. USA 93. 1677-1682.
22. FRIEDRICH, G.A. (1996) Moving beyond the genome projects. Nature Biotechnol 14: 1234-1237.
23. FRIEDRICH, G. and SORIANO, P. (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5: 1513-1523.
24. FRIEDRICH, G , HILDEBRAND, J.D. and SORIANO, P. (1997). The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev. Biol. 192: 364-374.
25. FROMONT-RACINE, M., RAIN, J.-C. and LEGRAIN, P. (1997). Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nature Genet. 16: 277-282
26. GOFFEAU, A., BARRELL, B G., BUSSEY, H., DAVIS, R.W , DUJON, B , FELDMANN, H , GALIBERT, F., HOHEISEL, J.D., JACQ, C., JOHNSTON, M., LOUIS, E J , MEWES, H.W , MURAKAMI, Y., PHILIPPSEN, P., TETTELIN, H. and OLIVER. S.G. (1996). Life with 6000 genes. Science 274: 563-567.
27. GOGOS, J A , LOWRY, W and KARAYIORGOU, M. (1997). Selection for retroviral insertions into regulated genes. J Virol. 71: 1644-1650.
28. GOGOS, J A., THOMPSON, R , LOWRY, W , SLOANE, B.F., WEINTRAUB, H. and HORWITZ, M. (1996). Gene trapping in differentiating cell lines regulation of the lysosomal protease cathepsin-B in skeletal myoblast growth and fusion J. Cell Biol. 134: 837-847
29. GOSSLER, A and ZACHGO, J. (1993) Gene targeting. Apractical approach In Gene trapping strategies: screens for developmentally regulated genes and insertional mutagenesis (Ed. A.L. Joyner). Vol Oxford Univ Press, New York, pp. 181-227.
30. GOSSLER, A., JOYNER, A., ROSSANT, J. and SKARNES, W.C. (1989). Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244. 463-465.
31. GUERIOS-FILHO, F.J. and BEVERLEY, S.M. (1997). Trans-kingdom transposition of the Drosophila element mariner within the protozoan Leishmania. Science 276. 1716-1719.
32. HICKS, G.G., SHI, E.-G., LI, X -M , LI, C.-H., PAWLAK, M. and RULEY, H E. (1997). Functional genomics in mice by tagged sequence mutagenesis. Nature Genet. 16: 338-344
33. HUBBARD, S.C., WALLS, L , RULEY, H.E and MUCHMORE, E A (1994). Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis J Biol. Chem. 269: 3717-3724.
34. IMAI, Y., SUZUKI, Y., MATSUI, T., TOHYAMA, M., WANAKA, A. and TAKAGI, T. (1995). Cloning of a retinoic acid-induced gene, GT1, in the embryonal carcinoma cell line P19: neuron-specific expression in the mouse brain. Mol. Brain Res. 31: 1-9.
35. IVICS, Z , HACKETT, P B., PLASTERK, R.H. and IZSVAK, Z. (1997). Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells Cell 91 501-510
36. JONSSON, J.-I., WU, Q., NILSSON, K. and PHILLIPS, R.A (1996). Use of a promoter-trap retrovirus to identify and isolate genes involved in differentiation of a myeloid progenitor cell line in vitro. Blood 87: 1771-1779.
37. KERR, W. and HERZENBERG, L.A. (1991). Gene-search viruses and FACS-Gal permit the detection, isolation, and characterization of mammalian cells with in situ fusions between cellular genes and Escherichia coli lacZ. In Methods: A Companion to Methods in Enzymology (Ed. Vol. 2.). pp. 261-271
38. KOTHARY, R., CLAPOFF, S., BROWN, A., CAMPBELL, R., PETERSON, A. and ROSSANT, J. (1988) A transgene containing lacZinserted into the dystonia locus is expressed in neural tube Nature 335. 435-437.
39. LI, L. and COHEN, S N (1996) tsg101 A novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell 85: 319-329.
40. LIANG, P. and PARDEE, A.B. (1995) Recent advances in differential display. Curr. Opin Immunol. 7: 274-280.
41. MORAN, J.V., HOLMES, S.E., NAAS, T.P , DEBERARDINIS, R.J., BOEKE, J.D. and KAZAZIAN, H.H., Jr (1996). High frequency retrotransposition in cultured mammalian cells. Cell 87: 917-927.
42. MURATA, T., USHIKUBI, F , MATSUOKA, T., HIRATA, M., YAMASAKI, A., SUGIOMOTO, Y., ICHIKAWA, A., AZE, Y., TANAKA, T , YOSHIDA, N., UENO, A., OH-ISHI, S. and NARUMIYA, S. (1997). Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388: 678-682
43. NIWA, H , ARAKI, K., KIMURA, S, TANIGUCHI, S., WAKASUGI, S. and YAMAMURA, K. (1993) An Efficient Gene-Trap Method Using Poly a Trap Vectors and Characterization of Gene-Trap Events J. Biochem. 113: 343-349
44. O'KANE, C.J and GEHRING, W J. (1987). Detection in situ of genomic regulatory elements in Drosophila. Proc. Natl. Acad Sci. USA 84. 9123-9127.
45. RAMIREZ-SOLIS, R., DAVIS, AC and BRADLEY, A. (1993). Gene targeting in embryonic stem cells. In Guide to techniques in mouse development (Ed. P M. Wassarman and M.L. DePamphilis). Methods in Enzymology, Vol. 225. Academic Press, Inc., New York, pp. 855-878.
46. RIJKERS, T and RUTHER, U. (1996). Sequence and expression pattern of an evolutionarily conserved transcript identified by gene trapping. Biochim. Biophys. Acta 1307. 294-300
47. ROSS, A.J., WAYMIRE,K G ,MOSS, J.E., PARLOW, A.F.,SKINNER, M.K., RUSSELL, L.D and MACGREGOR, G. R. (1998). Testicular degeneration in Bclw-deficient mice Nature Genet 18 251-256.
48. RUSS, A P , FRIEDEL, C., BALLAS, K., KALINA, U , ZAHN, D., STREBHARDT, K. and VON MELCHNER, H (1996). Identification of genes induced by factor deprivation in hematopoietic cells undergoing apoptosis using gene-trap mutagenesis and site-specific recombination. Proc Natl. Acad. Sci USA 93. 15279-15284.
49. SAKURAI, T., AMEMIYA, A , ISHII, M., MATSUZAKI, I., CHEMELLI, R.M , TANAKA, H., WILLIAMS, S C., RICHARDSON, J.A., KOZLOWSKI, G P , WILSON, S , ARCH, J R.S , BUCKINGHAM, R E , HAYNES, A.C., CARR, S A , ANNAN, R.S , MCNULTY, D.E., LIU, W.-S., TERRETT, J.A., ELSHOURBAGY,N.A., BERGSMA, D J. and YANAGISAWA, M (1998) Orexins and Orexin receptors a family of hypothalmic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585.
50. SASSAMAN, D.M , DOMBROSKI, B A., MORAN, J V., KIMBERLAND, M.L., NAAS, T P , DEBERARDINIS, R.J., GABRIEL, A , SWERGOLD, G.D. and KAZAZIAN, H.H , Jr. (1997) Many humans L1 elements are capable of retrotransposition. Nature Genet. 16: 37-43
51. SCHENA, M. (1996). Genome analysis with gene expression microarrays Bioessays 18: 427-431.
52. lacz, an insertional mutation on mouse Chromosome 12 with parental origin-dependent phenotype. Mammal. Genome 7: 20-24.
53. SENTRY, J.W., GOODWIN, S.F , MILLIGAN, C.D., DUNCANSON, A., YANG, M. and KAISER, K. (1994). Reverse genetics of Drosophila brain structure and function. Prog. Neurobiol. 42. 299-308.
54. SERAFINI, T., COLAMARINO, S.A , LEONARDO, E.D , WANG, H., BEDDINGTON, R., SKARNES, W.C. and TESSIER-LAVIGNE, M. (1996) Netnn-1 is required for commissural axon guidance in the developing vertebrate nervous system Cell 87: 1001-1014.
55. SHEVENKO, A , JENSEN, O.N , PODTELEJNIKOV, A.V., SAGLIOCCO, F , WILM, M., VORM, O., MORTENSEN, P., SHEVCHENKO, A., BOUCHERIE, H. and MANN, M (1996). Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc. Natl Acad. Sci. USA 93: 14440-14445.
56. SHOEMAKER, D.D., LASHKARI, D A., MORRIS, D., MITTMANN, M and DAVIS, R.W. (1996). Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nature Genet. 14: 450-456.
57. SKARNES, E., AUERBACK, B A. and JOYNER, A.L. (1992). A gene trap approach in mouse embryonic stem cells, the lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev 6. 903-918.
58. SKARNES, W., MOSS, J , HURTLEY, S. and BEDDINGTON, R (1995). Capturing genes encoding membrane and secreted proteins important for mouse development. Proc. Natl Acad. Sci. USA 92: 6592 - 6596.
59. TORRES, M , STOYKOVA, A , HUBER, O , CHOWDHURY, K., BONALDO, P , MANSOURI, A , BUTZ, R. and GRUSS, P. (1997). An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc. Natl. Acad Sci. USA 94 901-906.
60. TOWNLEY, D.J., AVERY, B J , ROSEN, B. and SKARNES, W.C. (1997). Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice. Genet. Res. 7: 293-298
61. VELCULESCU, V.E., ZHANG, L , VOGELSTEIN, B. and KINZLER, K.W (1995). Serial analysis of gene expression. Science 270: 484-487.
62. WILSON, C., PEARSON, R.K , BELLEN, H.J , O'KANE, C.J., GROSSNIKLAUS, U and GEHRING, W.J (1989) P-element-mediated enhancer detection an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev 3: 1301-1313
63. WISE, M.J., LITTLEJOHN, T.G and HUMPHERY-SMITH, I. (1997). Peptide-mass fingerprinting and the ideal covering set for protein characterisation. Electrophoresis 18: 1399-1409
64. WITHERS-WARD, E S., KITAMURA, Y , BARNES, J.P. and COFFIN, J.M (1994). Distribution of targets for avian retrovirus DNA integration in vivo Genes Dev 1473-1487
65. WURST, W , ROSSANT, J., PRIDEAUX, V , KOWNACKA, M., JOYNER, A L., HILL, D. and GUILLEMOT, F. (1995). A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice Genetics 139: 889-899.
66. YOSHIDA, M., YAGI, T., FURUTA, Y., TAKAYANAGI, K., KOMINAMI, R., TAKEDA, Y , TOKUNAGA, T , CHIBA, J , IKAWA, Y. and AIZAWA, S. (1995). A new strategy of gene trapping in ES cells using 3'RACE. Transgenic Res 4: 277-287.
67. YOU, Y , BERGSTROM, R., KLEMM, M., LEDERMAN, B., NELSON, H., TICKNOR, C., JAENISCH, R and SCHIMENTI, J. (1997). Chromosomal deletion complexes in mice by radiation of embryonic stem cells. Nature Genet. 285-288.
68. ZAMBROWICZ, B P., FRIEDRICH, G A , BUXTON, E.C , LILLEBERG, S.L., PERSON, C and SANDS, A.T (1998). Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392 608-611.
69. ZAMBROWICZ, B.P., IMAMOTO, A., FIERING, S., HERZENBERG, L.A , KERR, W.G and SORIANO, P. (1997) Disruption of overlapping transcripts in the ROSA b-geo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopioetic cells. Proc. Natl Acad. Sci. USA 94. 3789-3794.
70. ZWAAL, R R., BROEKS, A , VAN MEURS, J., GROENEN, J.T.M. and PLASTERK, R.H A. (1993). Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposen insertion mutant bank Proc. Natl Acad. Sci. USA 90: 7431-7435.