Family-based and case-control study of catechol-O-methyltransferase in schizophrenia among Palestinian Arabs

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 119 B, Issue 1, 2003, Pages 35-39

  Kremer, I ^a   Pinto, M ^b   Murad, I ^c   Muhaheed, M ^e   Bannoura, I ^c   Muller, D J ^e   Schulze, T G ^e   Reshef, A ^a   Blanaru, M ^a   Gathas, S ^a   Goichman, R ^a   Rietschel, M ^e   Dobrusin, M ^d   Bachner Melman, R ^b   Nemanov, L ^b   Belmaker, R H ^d   Maier, W ^e   Ebstein, R P ^b  

^a HAEMEK MEDICAL CENTER   (Israel)

^b HERZOG HOSPITAL   (Israel)

^c Dr Kemal Psychiatric Hospital   (Palestine)

^d MENTAL HEALTH CENTER   (Israel)

^e Rehov Givat S ^*

Author keywords

Arab; Association; Catechol O methyltransferase; Linkage; Schizophrenia; Transmission disequilibrium test

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

ADULT; AMINO ACID SUBSTITUTION; ARAB; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME METABOLISM; ETHNOLOGY; FAMILY; FEMALE; GENE DELETION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; HEREDITY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PALESTINE; PRIORITY JOURNAL; PSYCHOSIS; RISK FACTOR; SCHIZOPHRENIA; THERMOSTABILITY;

EID: 10744225915     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20008     Document Type: Article

References (47)

1. Alsobrook JP II, Zohar AH, Leboyer M, Chabane N, Ebstein RP, Pauls DL. 2002. Association between the COMT locus and obsessive-compulsive disorder in females but not males. Am J Med Genet 114(1):116-120.
2. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders. 4th edn. Washington DC: American Psychiatric Association.
3. Chen CH, Lee YR, Liu MY, Wei FC, Koong FJ, Hwu HG, Hsiao KJ. 1996. Identification of a BglI polymorphism of catechol-O-methyltransferase (COMT) gene, and association study with schizophrenia. Am J Med Genet 67(6):556-559.
4. Daly G, Hawi Z, Fitzgerald M, Gill M. 1999. Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 4(2):192-196.
5. de Chaldee M, Laurent C, Thibaut F, Martinez M, Samolyk D, Petit M, Campion D, Mallet J. 1999. Linkage disequilibrium on the COMT gene in French schizophrenics and controls. Am J Med Genet 88(5):452-457.
6. de Chaldee M, Corbex M, Campion D, Jay M, Samolyk D, Petit M, Thibaut F, Laurent C, Mallet J. 2001. No evidence for linkage between COMT and schizophrenia in a French population. Psychiatry Res 102(1):87-90.
7. Dobrusin M, Corbex M, Kremer I, Murad I, Muhaheed M, Bannoura I, Muller DJ, Schulze TG, Reshef A, Blanaru M, Gathas S, Rietschel M, Belmaker RH, Maier W, Ebstein RP. 2001. No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population. Am J Med Genet 105(4):328-331.
8. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98(12):6917-6922.
9. Eisenberg J, Mei-Tal G, Steinberg A, Tartakovsky A, Zohar A, Gritsenko I, Nemanov L, Ebstein RP. 1999. Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): Association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Am J Med Genetics (Neuropsychiatr Genet) 88(5):497-502.
10. Ewens WJ, Spielman RS. 1995. The transmission/disequilibrium test: History, subdivision and admixture. Am J Hum Genet 57:455-464.
11. Fan JB, Chen WY, Tang JX, Li S, Gu NF, Feng GY, Breen G, St Clair D, He L. 2002. Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. Mol Psychiatry 7(5):446-447.
12. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT. 2000. Neuropsychologic functioning amongthe nonpsychotic relatives of schizophrenic patients: The effect of genetic loading. Biol Psychiatry 48(2):120-126.
13. Hamer D, Sirota L. 2000. Beware the chopsticks gene. Mol Psychiatry 5(1):11-13.
14. Horowitz R, Kotler M, Shufman E, Aharoni S, Kremer I, Cohen H, Ebstein RP. 2000. Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study [In Process Citation]. Am J Med Genet 96(5):599-603.
15. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. 2001. Replication validity of genetic association studies. Nat Genet 29(3):306-309.
16. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. 1997. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 94(9):4572-4575.
17. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P, Ott J, Gogos JA. 1999. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder [In Process Citation]. Biol Psychiatry 45(9):1178-1189.
18. Kotler M, Barak P, Cohen H, Averbuch IE, Grinshpoon A, Gritsenko I, Nemanov L, Ebstein RP. 1999. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol-O-methyltransferase (COMT) activity. Am J Med Genet 88(6):628-633.
19. Kunugi H, Vallada HP, Sham PC, Hoda F, Arranz MJ, Li T, Nanko S, Murray RM, McGuffin P, Owen M, Gill M, Collier DA. 1997. Catechol-O-methyltransferase polymorphisms and schizophrenia: A transmission disequilibrium study in multiply affected families. Psychiatr Genet 7(3): 97-101.
20. Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF. 1996a. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am J Med Genet 67(5):468-472.
21. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. 1996b. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6(3):243-250.
22. Lachman HM, Nolan KA, Mohr P, Saito T, Volavka J. 1998. Association between catechol-O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 155(6):835-837.
23. Leung A, Chue P. 2000. Sex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand (Suppl) 401:3-38.
24. Li T, Sham PC, Vallada H, Xie T, Tang X, Murray RM, Liu X, Collier DA. 1996. Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet 6(3):131-133.
25. Liou YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC. 2001. Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology 43(1):11-14.
26. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J. 1995. Kinetics of human soluble and membrane-bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34(13):4202-4210.
27. Mannisto PT, Kaakkola S. 1999. Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51(4):593-628.
28. Moriarty PJ, Lieber D, Bennett A, White L, Parrella M, Harvey PD, Davis KL. 2001. Gender differences in poor outcome patients with lifelong schizophrenia. Schizophr Bull 27(1):103-113.
29. Mujaheed M, Corbex M, Lichtenberg P, Levinson DF, Deleuze JF, Mallet J, Ebstein RP. 2000. Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a Palestinian Arab population. Am J Med Genet 96(6): 836-838.
30. Murad I, Kremer I, Dobrusin M, Muhaheed M, Bannoura I, Muller DJ, Schulze TG, Reshef A, Blanaru M, Gathas S, Tsenter V, Rietschel M, Belmaker RH, Maier W, Ebstein RP. 2001. A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. Am J Med Genet 105(3):236-238.
31. Murphy KC, Jones RG, Griffiths E, Thompson PW, Owen MJ. 1998. Chromosome 22qII deletions. An under-recognised cause of idiopathic learning disability. Br J Psychiatry 172:180-183.
32. Murphy KC, Jones LA, Owen MJ. 1999. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 56(10):940-945.
33. Nolan KA, Volavka J, Czobor P, Cseh A, Lachman H, Saito T, Tiihonen J, Putkonen A, Hallikainen T, Kotilainen I, Rasanen P, Isohanni M, Jarvelin MR, Karvonen MK. 2000. Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatr Genet 10(3): 117-124.
34. Norton N, Kirov G, Zammit S, Jones G, Jones S, Owen R, Krawczak M, Williams NM, O'Donovan MC, Owen MJ. 2002. Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis. Am J Med Genet 114(5):491-496.
35. Ohara K, Nagai M, Suzuki Y, Ochiai M. 1998. No association between anxiety disorders and catechol-O-methyltransferase polymorphism [In Process Citation]. Psychiatry Res 80(2):145-148.
36. Ohmori O, Shinkai T, Kojima H, Terao T, Suzuki T, Mita T, Abe K. 1998. Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics. Neurosci Lett 243(1-3): 109-112.
37. Pulver AE, Nestadt G, Goldberg R, Shprintzen RJ, Lamacz M, Wolyniec PS, Morrow B, Karayiorgou M, Antonarakis SE, Housman D, et al. 1994. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 182(8):476-478.
38. Roy MA, Maziade M, Labbe A, Merette C. 2001. Male gender is associated with deficit schizophrenia: A meta-analysis. Schizophr Res 47(2-3): 141-147.
39. Semwal P, Prasad S, Bhatia T, Deshpande SN, Wood J, Nimgaonkar VL, Thelma BK. 2001. Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia. Mol Psychiatry 6(2):220-224.
40. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risch N, Zak NB, Darvasi A. 2002. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71(6):6.
41. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent Diabetes mellitus (IDDM). Am J Hum Genet 52(3):506-516.
42. Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. 1997a. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: Evidence for association with aggressive and antisocial behavior. Psychiatry Res 69(2-3):71-77.
43. Strous RD, Bark N, Woerner M, Lachman HM. 1997b. Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia. Biol Psychiatry 41(4):493-495.
44. Vandenbergh DJ, Rodriguez LA, Miller IT, Uhl GR, Lachman HM. 1997. High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Am J Med Genet 74(4):439-442.
45. Wei J, Hemmings GP. 1999. Lack of evidence for association between the COMT locus and schizophrenia. Psychiatr Genet 9(4):183-186.
46. Weinshilboum RM, Raymond FA. 1977. Inheritance of low erythrocyte catechol-o-methyltransferase activity in man. Am J Hum Genet 29(2): 125-135.
47. Weiser M, Reichenberg A, Rabinowitz J, Kaplan Z, Mark M, Nahon D, Davidson M. 2000. Gender differences in premorbid cognitive performance in a national cohort of schizophrenic patients. Schizophr Res 45(3):185-190.