2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 22, 2003, Pages 4693-4711

  Pez, Didier ^a   Leal, Isabel ^b   Zuccotto, Fabio ^a   Boussard, Cyrille ^a   Brun, Reto ^c   Croft, Simon L ^d   Yardley, Vanessa ^d   Ruiz Perez, Luis M ^b   Gonzalez Pacanowska, Dolores ^b   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; 5 (3 HEXYLOXY 4 OCTYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (3 HEXYLOXY 4 PROPYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (3,4 DIPROPOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 BENZYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 DECYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 HEPTYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 HEXYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 HYDROXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 NONYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 OCTYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4 PENTYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 (4' METHYLOXYBENZYL) 2,4 DIAMINOPYRIMIDINE; 5 [4 (TETRAHYDRO 2 PYRANOXY)BENZYL] 2,4 DIAMINOPYRIMIDINE; DIHYDROFOLATE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG EFFECT; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; IN VITRO STUDY; LEISHMANIA DONOVANI; LIPOPHILICITY; MOLECULAR MODEL; NONHUMAN; PARASITE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

LEISHMANIA DONOVANI; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 10744224199     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.08.012     Document Type: Article

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