8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity

Mutation Research - DNA Repair

Volumn 385, Issue 1, 1997, Pages 75-82

  Shinmura, Kazuya ^a,c   Kasai, Hiroshi ^b   Sasaki, Atsushi ^a   Sugimura, Haruhiko ^c   Yokota, Jun ^a  

^a NATIONAL CANCER CENTER   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

8 hydroxyguanine; Base excision repair; Endonuclease; Glycosylase; mutM; OGG1

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLTRANSFERASE;

ARTICLE; DNA DAMAGE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EXCISION REPAIR; GLYCOSYLATION; HUMAN; MOLECULAR CLONING; PRIORITY JOURNAL;

CARBON-OXYGEN LYASES; DEOXYGUANOSINE; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; HUMANS; N-GLYCOSYL HYDROLASES; NUCLEIC ACID HETERODUPLEXES; OLIGODEOXYRIBONUCLEOTIDES; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0030724904     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(97)00041-4     Document Type: Article

References (27)

1. H. Kasai, S. Nishimura, Formation of 8-hydroxyguanosine in DNA by oxygen radicals and its biological significance, Oxidative stress: Oxidants and Antioxidants, Academic Press, London, 1991, pp. 99-116.
2. Michaels M.L., Miller J.H. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J. Bacteriol. 174:1992;6321-6325.
3. Grollman A.P., Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9:1993;246-249.
4. Kasai H., Nishimura S. DNA damage induced by asbestos in the presence of hydrogen peroxide. Gann. 75:1984;841-844.
5. Kasai H., Nishimura S. Hydroxylation of deoxyguanine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion. Gann. 75:1984;565-566.
6. Nagashima M., Kasai H., Yokota J., Nagamachi Y., Ichinose T., Sagai M. Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process. Carcinogenesis. 16:1995;1441-1445.
7. Wood M.L., Dizdaroglu M., Gajewski E., Essigmann J.M. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry. 29:1990;7024-7032.
8. Moriya M., Ou C., Bodepudi V., Johnson F., Takeshita M., Grollman A.P. Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in E. coli. Mutat. Res. 254:1991;281-288.
9. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J. Biol. Chem. 267:1992;166-172.
10. Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 349:1991;431-434.
11. Au K.G., Clark S., Miller J.H., Modrich P. Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. Proc. Natl. Acad. Sci. USA. 86:1989;8877-8881.
12. Tchou J., Kasai H., Shibutani S., Chung M.H., Laval J., Grollman A.P., Nishimura S. 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc. Natl. Acad. Sci. USA. 88:1991;4690-4694.
13. Boiteux S., Gajewski E., Laval J., Dizdaroglu M. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry. 31:1992;106-110.
14. Michaels M.L., Tchou J., Grollman A.P., Miller J.H. A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry. 31:1992;10964-10968.
15. Maki H., Sekiguchi M. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature. 355:1992;273-275.
16. Nagashima M., Sasaki A., Morishita K., Takenoshita S., Nagamachi Y., Kasai H., Yokota J. Presence of human cellular protein(s) that specifically binds and cleaves 8-hydroxyguanine containing DNA. Mutat. Res. 383:1997;49-59.
17. Auffret van der Kemp P., Thomas D., Barbey R., de Oliveira R., Boiteux S. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc. Natl. Acad. Sci. USA. 93:1996;5197-5202.
18. Arai K., Morishita K., Shinmura K., Kohno T., Kim S.-R., Nohmi T., Taniwaki S., Ohwada S., Yokota J. Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage. Oncogene. 14:1997;2857-2861.
19. Nash H.M., Bruner S.D., Scharer O.D., Kawate T., Addona T.A., Spooner E., Lane W.S., Verdine G.L. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr. Biol. 6:1996;968-980.
20. Bodepudi V., Shibutani S., Johnson F. Synthesis of 2′-deoxy-7,8-dihydro-8-oxoguanosine and 2′-deoxy-7,8-dihydro-8-oxoadenosine and their incorporation into oligomeric DNA. Chem. Res. Toxicol. 5:1992;608-617.
21. Tchou J., Grollman A.P. The catalytic mechanism of Fpg protein. Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site. J. Biol. Chem. 270:1995;11671-11677.
22. Zharkov D., Rieger R., Iden C., Grollman A.P. NH2-terminal proline acts as a nucleophile in the glycosylase/AP-lyase reaction catalyzed by Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg) protein. J. Biol. Chem. 272:1997;5335-5341.
23. Neddermann P., Gallinari P., Lettieri T., Schmid D., Truong O., Hsuan J.J., Wiebauer K., Jiricny J. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. J. Biol. Chem. 271:1996;12767-12774.
24. Slupska M.M., Baikalov C., Luther W.M., Chiang J.H., Wei Y.F., Miller J.H. Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J. Bacteriol. 178:1996;3885-3892.
25. Aspinwall R., Rothwell D., Roldan-Arjona T., Anselmino C., Ward C., Cheadle J., Sampson J., Lindahl T., Harris P., Hickson I. Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. Proc. Natl. Acad. Sci. USA. 94:1997;109-114.
26. Lu R., Nash H.M., Verdine G.L. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Curr. Biol. 7:1997;397-407.
27. Aburatani H., Hippo Y., Ishida T., Takashima R., Matsuba C., Kodama T., Takao M., Yasui A., Yamamoto K., Asano M., Fukasawa K., Yoshinari T., Inoue H., Ohtsuka E., Nishimura S. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res. 57:1997;2151-2156.