Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA

Journal of Lipid Research

Volumn 45, Issue 2, 2004, Pages 387-395

  Siggins, Sarah ^a   Kärkkäinen, Minna ^a   Tenhunen, Jukka ^a   Metso, Jari ^a   Tahvanainen, Esa ^a   Olkkonen, Vesa M ^a   Jauhiainen, Matti ^a   Ehnholm, Christian ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Enzyme linked immunosorbent assay; High activity form of phospholipid transfer protein; Lipid transfer protein; Low activity form of phospholipid transfer protein

Indexed keywords

CALCIUM CHLORIDE; DETERGENT; DEXTRAN SULFATE; LIPID TRANSFER PROTEIN; MONOCLONAL ANTIBODY; PHOSPHOLIPID TRANSFER PROTEIN; POLYCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOREACTIVITY; LIPOPROTEIN METABOLISM; PHOSPHOLIPID TRANSFER; PLASMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BLOOD PROTEINS; CARRIER PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MIDDLE AGED; PHOSPHOLIPID TRANSFER PROTEINS; PROTEIN DENATURATION; RECOMBINANT PROTEINS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 10744220658     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.D300023-JLR200     Document Type: Article

References (40)

1. Huuskonen, J., V. M. Olkkonen, M. Jauhiainen, and C. Ehnholm. 2001. The impact of phospholipid transfer protein (PLTP) on HDL metabolism. Atherosclerosis. 155: 269-281.
2. Tall, A. 1995. Plasma lipid transfer proteins. Annu. Rev. Biochem. 64: 235-257.
3. Jauhiainen, M., J. Huuskonen, M. Baumann, J. Metso, T. Oka, T. Egashira, H. Hattori, V. M. Olkkonen, and C. Ehnholm. 1999. Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I. J. Lipid Res. 40: 654-664.
4. Jauhiainen, M., J. Metso, R. Pahlman, S. Blomqvist, A. van Tol, and C. Ehnholm. 1993. Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J. Biol. Chem. 268: 4032-4036.
5. Tu, A-Y., H. Nishida, and T. Nishida. 1993. High density lipoprotein conversion mediated by human plasma phospholipid transfer protein. J. Biol. Chem. 268: 23098-23105.
6. Lagrost, L., A. Athias, P. Gambert, and C. Lallemant. 1994. Comparative study of phospholipid transfer activities mediated by cholesteryl ester transfer protein and phospholipid transfer protein. J. Lipid Res. 35: 825-835.
7. Jiang, X. C., C. Bruce, J. Mar, M. Lin, Y. Ji, O. Francone, and A. R. Tall. 1999. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J. Clin. Invest. 103: 907-914.
8. Kawano, K., S. C. Qin, M. Lin, A. R. Tall, and X. C. Jiang. 2000. Cholesteryl ester transfer protein and phospholipid transfer protein have nonoverlapping functions in vivo. J. Biol. Chem. 275: 29477-29481.
9. Foger, B., S. Santamarina-Fojo, R. D. Shamburek, C. L. Parrot, G. D. Talley, and H. B. Brewer, Jr. 1997. Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL. J. Biol. Chem. 272: 27393-27400.
10. Jiang, X. C., O. L. Francone, C. Bruce, R. Milne, J. Mar, A. Walsh, J. L. Breslow, and A. R. Tall. 1996. Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes. J. Clin. Invest. 98: 2373-2380.
11. Ehnholm, S., K. W. van Dijk, B. van't Hof, A. van der Zee, V. M. Olkkonen, M. Jauhiainen, M. Hofker, L. Havekes, and C. Ehnholm. 1998. Adenovirus-mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice. J. Lipid Res. 39: 1248-1253.
12. van Haperen, R., A. van Tol, P. Vermeulen, M. Jauhiainen, T. van Gent, P. van den Berg, S. Ehnholm, F. Grosveld, A. van der Kamp, and R. de Crom. 2000. Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice. Arterioscler. Thromb. Vasc. Biol. 20: 1082-1088.
13. Qin, S., K. Kawano, C. Bruce, M. Lin, C. Bisgaier, A. R. Tall, and X. C. Jiang. 2000. Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins. J. Lipid Res. 41: 269-276.
14. Bouly, M., D. Masson, B. Gross, X. C. Jiang, C. Fievet, G. Castro, A. R. Tall, J. C. Fruchart, B. Staels, L. Lagrost, and G. Luc. 2001. Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate. J. Biol. Chem. 276: 25841-25847.
15. Jiang, X. C., S. Qin, C. Qiao, K. Kawano, M. Lin, A. Skold, X. Xiao, and A. R. Tall. 2001. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat. Med. 7: 847-852.
16. Kawano, K., S. Quin, M. Lin, A. R. Tall, and X. C. Jiang. 1999. A synergistic increase in FC and CE in VLDL/LDL in mice with combined HL/PLTP deficiency suggests ajoint role in selective uptake from VLDL. Circ. Suppl. 100: I.
17. Lie, J., R. de Crom, T. van Gent, R. van Haperen, L. Scheek, I. Lankhuizen, and A. van Tol. 2002. Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion. J. Lipid Res. 43: 1875-1880.
18. Van Haperen, R., A. van Tol, T. van Gent, L. Scheek, P. Visser, A. van Der Kamp, F. Grosveld, and R. de Crom. 2002. Increased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein. J. Biol. Chem. 277: 48938-48943.
19. Riemens, S. C., A. van Tol, W. J. Sluiter, and R. P. Dullaart. 1998. Plasma phospholipid transfer protein activity is related to insulin resistance: impaired acute lowering by insulin in obese type II diabetic patients. Diabetologia. 41: 929-934.
20. Riemens, S. C., A. van Tol, W. J. Sluiter, and R. P. Dullaart. 1999. Plasma phospholipid transfer protein activity is lowered by 24-h insulin and acipimox administration: blunted response to insulin in type 2 diabetic patients. Diabetes. 48: 1631-1637.
21. Kaser, S., A. Sandhofer, B. Foger, C. F. Ebenbichler, B. Igelseder, L. Malaimare, B. Paulweber, and J. R. Patsch. 2001. Influence of obesity and insulin sensitivity on phospholipid transfer protein activity. Diabetologia. 44: 1111-1117.
22. Cheung, M. C., G. Wolfbauer, H. Kennedy, B. G. Brown, and J. J. Albers. 2001. Plasma phospholipid transfer protein activity in patients with low HDL and cardiovascular disease treated with simvastatin and niacin. Biochim. Biophys. Acta. 1537: 117-124.
23. Desrumaux, C., A. Athias, G. Bessede, B. Verges, M. Farnier, L. Persegol, P. Gambert, and L. Lagrost. 1999. Mass concentration of plasma phospholipid transfer protein in normolipidemic, type IIa hyperlipidemic, type IIb hyperlipidemic, and non-insulin-dependent diabetic subjects as measured by a specific ELISA. Arterioscler. Thromb. Vasc. Biol. 19: 266-275.
24. Huuskonen, J., M. Ekström, E. Tahvanainen, A. Vainio, J. Metso, P. Pussinen, C. Ehnholm, V. M. Olkkonen, and M. Jauhiainen. 2000. Quantification of human plasma phospholipid transfer protein (PLTP): relationship between PLTP mass and phospholipid transfer activity. Atherosclerosis. 151: 451-461.
25. Oka, T., T. Kujiraoka, M. Ito, M. Nagano, M. Ishihara, T. Iwasaki, T. Egashira, N. E. Miller, and H. Hattori. 2000. Measurement of human plasma phospholipid transfer protein by sandwich ELISA. Clin. Chem. 46: 1357-1364.
26. Oka, T., S. Yamashita, T. Kujiraoka, M. Ito, M. Nagano, Y. Sagehashi, T. Egashira, M. N. Nanjee, K. Hirano, N. E. Miller, Y. Matsuzawa, and H. Hattori. 2002. Distribution of human plasma PLTP mass and activity in hypo- and hyperalphalipoproteinemia. J. Lipid Res. 43: 1236-1243.
27. Murdoch, S.J., G. Wolfbauer, H. Kennedy, S. M. Marcovina, M. C. Carr, and J. J. Albers. 2002. Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement. J. Lipid Res. 43: 281-289.
28. Oka, T., T. Kujiraoka, M. Ito, T. Egashira, S. Takahashi, M. N. Nanjee, N. E. Miller, J. Metso, V. M. Olkkonen, C. Ehnholm, M. Jauhiainen, and H. Hattori. 2000. Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive. J. Lipid Res. 41: 1651-1657.
29. Kärkkäinen, M., T. Oka, V. M. Olkkonen, J. Metso, H. Hattori, M. Jauhiainen, and C. Ehnholm. 2002. Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP). J. Biol. Chem. 277: 15413-15418.
30. Aromaa, A., and S. Koskinen, editors. 2002. Health and Functional Capacity in Finland: Baseline Results of the Health 2000 Health Examination Survey. National Public Health Institute, Helsinki, Finland.
31. 3 in vitro and its effect on PLTP-mediated phospholipid transfer. Biochim. Biophys. Acta. 1391: 181-192.
32. Huuskonen, J., V. M. Olkkonen, C. Ehnholm, J. Metso, I. Julkunen, and M. Jauhiainen. 2000. Phospholipid transfer is a prerequisite for PLTP-mediated HDL conversion. Biochemistry. 39: 16092-16098.
33. Huuskonen, J., G. Wohlfahrt, M. Jauhiainen, C. Ehnholm, O. Teleman, and V. M. Olkkonen. 1999. Structure and phospholipid transfer activity of human PLTP: analysis by molecular modeling and site-directed mutagenesis. J. Lipid Res. 40: 1123-1130.
34. Settasatian, N., M. Duong, L. K. Curtiss, C. Ehnholm, M. Jauhiainen, J. Huuskonen, and K-A. Rye. 2001. The mechanism of the remodelling of high density lipoproteins by phospholipid transfer protein. J. Biol. Chem. 276: 26898-26905.
35. 14C]phosphatidylcholine between liposomes and human plasma high-density lipoprotein. Partial purification of a transfer-stimulating plasma factor using a rapid transfer assay. Biochim. Biophys. Acta. 712: 444-452.
36. Kato, H., T. Nakanishi, T. Arai, H. I. Nishida, and T. Nishida. 1988. Purification, microheterogeneity, and stability of human lipid transfer protein. J. Biol. Chem. 264: 4082-4087.
37. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227: 680-685.
38. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76: 4350-4354.
39. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
40. Siggins, S., M. Jauhiainen, V. M. Olkkonen, J. Tenhunen, and C. Ehnholm. 2003. Phospholipid transfer protein (PLTP) secreted by HepG2 cells resembles the high-activity PLTP form in human plasma. J. Lipid Res. 44: 1453-1461.