-
1
-
-
0034020630
-
Mammalian telomeres and telomerase
-
Collins, K. Mammalian telomeres and telomerase. Curr. Opin. Cell. Biol. 2000, 12, 378-383.
-
(2000)
Curr. Opin. Cell. Biol.
, vol.12
, pp. 378-383
-
-
Collins, K.1
-
2
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley, C. B. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res. 1991, 256, 271-282.
-
(1991)
Mutat. Res.
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
3
-
-
0025729836
-
Defining the molecular mechanisms of human cell immortalization
-
Shay, W. J.; Wright, W. E.; Werbin, H. Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta - Rev. Cancer 1991, 1072, 1-7.
-
(1991)
Biochim. Biophys. Acta - Rev. Cancer
, vol.1072
, pp. 1-7
-
-
Shay, W.J.1
Wright, W.E.2
Werbin, H.3
-
4
-
-
0031010342
-
A Survey of Telomerase Activity in Human Cancer
-
Shay, W. J.; Bacchetti S. A Survey of Telomerase Activity in Human Cancer. Eur. J. Cancer 1997, 33, 787-791.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 787-791
-
-
Shay, W.J.1
Bacchetti, S.2
-
5
-
-
0032739776
-
Recent advances in the development of telomerase inhibitors for the treatment of cancer
-
Perry; P. J.; Jenkins, T. C. Recent advances in the development of telomerase inhibitors for the treatment of cancer. Exp. Opin. Invest. Drugs 1999, 8 (12), 1981-2008.
-
(1999)
Exp. Opin. Invest. Drugs
, vol.8
, Issue.12
, pp. 1981-2008
-
-
Perry, P.J.1
Jenkins, T.C.2
-
6
-
-
0033170136
-
Telomerase as an anti-cancer target: Current status and future prospects
-
Neidle, S.; Kelland, L. R. Telomerase as an anti-cancer target: current status and future prospects. Anti-Cancer Drug Des. 1999, 14, 341-347.
-
(1999)
Anti-Cancer Drug Des.
, vol.14
, pp. 341-347
-
-
Neidle, S.1
Kelland, L.R.2
-
7
-
-
0034705013
-
Inhibition of Human Telomerase by Rubromycins: Implication of Spiroketal System of the Compounds as an Active Moiety
-
Ueno, T.; Takahashi, H.; Oda, M.; Mizunuma, M.; Yokoyama, A.; Goto, Y.; Mizushina, Y.; Sagakuchi, K.; Hayashi, H. Inhibition of Human Telomerase by Rubromycins: Implication of Spiroketal System of the Compounds as an Active Moiety. Biochemistry 2000, 39, 5995-6002.
-
(2000)
Biochemistry
, vol.39
, pp. 5995-6002
-
-
Ueno, T.1
Takahashi, H.2
Oda, M.3
Mizunuma, M.4
Yokoyama, A.5
Goto, Y.6
Mizushina, Y.7
Sagakuchi, K.8
Hayashi, H.9
-
8
-
-
0032249255
-
Inhibition of human telomerase activity by alterperylenol
-
Ken-ichi, T.; Hideaki, K.; Masayuki, M.; You-Xin, S.; Hiroyuki, O. Inhibition of human telomerase activity by alterperylenol. Oncol. Res. 1998, 10, 449-453.
-
(1998)
Oncol. Res.
, vol.10
, pp. 449-453
-
-
Ken-ichi, T.1
Hideaki, K.2
Masayuki, M.3
You-Xin, S.4
Hiroyuki, O.5
-
9
-
-
0032904473
-
Diazaphilonic acid a new azaphilone with telomerase inhibitory activity
-
Yuji, T.; Shuji, I.; Takashi, Y.; Toru, S.; Shigeru, H.; Sadatoshi, S.; Kazauo, S.; Haruo, S. Diazaphilonic acid a new azaphilone with telomerase inhibitory activity. J. Antibiot. 1999, 52, 412-414.
-
(1999)
J. Antibiot.
, vol.52
, pp. 412-414
-
-
Yuji, T.1
Shuji, I.2
Takashi, Y.3
Toru, S.4
Shigeru, H.5
Sadatoshi, S.6
Kazauo, S.7
Haruo, S.8
-
10
-
-
0032547230
-
Telomerase Inhibition, Telomere Shortening, and Senescence of Cancer Cells by Tea Catechins
-
Naasani, I.; Seimiya, H.; Tsuruo, T. Telomerase Inhibition, Telomere Shortening, and Senescence of Cancer Cells by Tea Catechins. Biochem. Biophys. Res. Commun. 1998, 249, 391-396.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.249
, pp. 391-396
-
-
Naasani, I.1
Seimiya, H.2
Tsuruo, T.3
-
11
-
-
3042911716
-
Growth and telomerase inhibition of SK-MEL 28 melanoma cell line by a plant flavonoid, apigenin
-
Sang Sun, K.; Seung Eu, L.; Growth and telomerase inhibition of SK-MEL 28 melanoma cell line by a plant flavonoid, apigenin. J. Biochem. Mol. Biol. 1998, 31, 339-344.
-
(1998)
J. Biochem. Mol. Biol.
, vol.31
, pp. 339-344
-
-
Sang Sun, K.1
Seung Eu, L.2
-
12
-
-
0025885064
-
Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia
-
Deschner, E.; Ruperto, J.; Wong, G.; Newmark, H. L. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 1991, 12 (7), 1193-1196.
-
(1991)
Carcinogenesis
, vol.12
, Issue.7
, pp. 1193-1196
-
-
Deschner, E.1
Ruperto, J.2
Wong, G.3
Newmark, H.L.4
-
13
-
-
0027939130
-
Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis
-
Elangovan, V.; Sekar, N.; Govindasamy, S. Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis. Cancer Lett. 1994, 87, 107-113.
-
(1994)
Cancer Lett.
, vol.87
, pp. 107-113
-
-
Elangovan, V.1
Sekar, N.2
Govindasamy, S.3
-
14
-
-
0030596107
-
Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells
-
Kuo, S. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett. 1996, 110, 41-48.
-
(1996)
Cancer Lett.
, vol.110
, pp. 41-48
-
-
Kuo, S.1
-
15
-
-
0026516688
-
Inhibitory effects of flavonoids on moloney murine leukemia virus reverse transcriptase activity
-
Chu, S. C.; Hsieh, Y. S.; Lin, J. Y. Inhibitory effects of flavonoids on moloney murine leukemia virus reverse transcriptase activity. J. Nat. Prod. 1992, 55 (2), 179-183.
-
(1992)
J. Nat. Prod.
, vol.55
, Issue.2
, pp. 179-183
-
-
Chu, S.C.1
Hsieh, Y.S.2
Lin, J.Y.3
-
16
-
-
0025700717
-
Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases
-
Ono, K.; Nakane, H.; Fukushima, M.; Chermann, J. C.; Barrè- Sinoussi, F. Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur. J. Biochem. 1990, 190, 469-476.
-
(1990)
Eur. J. Biochem.
, vol.190
, pp. 469-476
-
-
Ono, K.1
Nakane, H.2
Fukushima, M.3
Chermann, J.C.4
Barrè-Sinoussi, F.5
-
17
-
-
37049153519
-
Synthetical experiments in the chromone group. Part VII. Synthesis of 7,8,4′-trihydroxy-, 7,8,3′,4′-tetrahydroxy-, and 7,8,3′,4′,5′-, 5,7,3′,4′,5′-, and 3,7,3′,4′,5′-pentahydroxyflavones
-
Badhwar, I. C.; Kang, K. S.; Venkataraman, K. Synthetical experiments in the chromone group. Part VII. Synthesis of 7,8,4′-trihydroxy-, 7,8,3′,4′-tetrahydroxy-, and 7,8,3′,4′,5′-, 5,7,3′,4′,5′-, and 3,7,3′,4′,5′- pentahydroxyflavones. J. Chem. Soc. 1932, 1107-1112.
-
(1932)
J. Chem. Soc.
, pp. 1107-1112
-
-
Badhwar, I.C.1
Kang, K.S.2
Venkataraman, K.3
-
18
-
-
0000474234
-
A short and facile synthetic route to hydroxylated flavones. New syntheses of apigenin, tricin, and luteolin
-
Nagarathnam, D.; Cushman, M. A short and facile synthetic route to hydroxylated flavones. New syntheses of apigenin, tricin, and luteolin. J. Org. Chem. 1991, 56 (16), 4884-4887.
-
(1991)
J. Org. Chem.
, vol.56
, Issue.16
, pp. 4884-4887
-
-
Nagarathnam, D.1
Cushman, M.2
-
20
-
-
33748899925
-
Molecular rearrangement of some o-acyloxyacetophenones and the mechanism of the production of 3-acylchromones
-
Baker, W. Molecular rearrangement of some o-acyloxyacetophenones and the mechanism of the production of 3-acylchromones. J. Chem. Soc. 1933, 1381-1388.
-
(1933)
J. Chem. Soc.
, pp. 1381-1388
-
-
Baker, W.1
-
21
-
-
0242435492
-
Synthetical experiments in the chromone group. Part XIV. The action of sodamide on 1-acyloxy-2-acetonaphthones
-
Mahal, H. S.; Venkataraman, K. Synthetical experiments in the chromone group. Part XIV. The action of sodamide on 1-acyloxy-2-acetonaphthones. J. Chem. Soc. 1934, 1767-1769.
-
(1934)
J. Chem. Soc.
, pp. 1767-1769
-
-
Mahal, H.S.1
Venkataraman, K.2
-
22
-
-
0001665193
-
Flavone
-
Wiley: New York
-
Wheeler, T. S. Flavone. Organic Syntheses; Wiley: New York, 1963; Collect. Vol. IV, pp 478-481.
-
(1963)
Organic Syntheses
, vol.4 COLLECT. VOL.
, pp. 478-481
-
-
Wheeler, T.S.1
-
23
-
-
0029783118
-
Synthesis and biological activity of 4-amino-5-chloro-2-ethoxy-3- hydroxybenzamides, metabolites of a new gastroprokinetic agent, mosapride
-
Kato, S.; Morie, T.; Yoshida, N. Synthesis and biological activity of 4-amino-5-chloro-2-ethoxy-3-hydroxybenzamides, metabolites of a new gastroprokinetic agent, mosapride. Chem. Pharm. Bull. 1996, 44 (8), 1484-1492.
-
(1996)
Chem. Pharm. Bull.
, vol.44
, Issue.8
, pp. 1484-1492
-
-
Kato, S.1
Morie, T.2
Yoshida, N.3
-
24
-
-
0001469447
-
Studies on 3-acylcathecols. II.1 A new synthesis of 8-hydroxyflavone
-
Awad, W. I.; El-Neweihy, M. F.; Selim, S. F. Studies on 3-acylcathecols. II.1 A new synthesis of 8-hydroxyflavone. J. Org. Chem. 1960, 25 (8), 1333-1336.
-
(1960)
J. Org. Chem.
, vol.25
, Issue.8
, pp. 1333-1336
-
-
Awad, W.I.1
El-Neweihy, M.F.2
Selim, S.F.3
-
25
-
-
33751156790
-
Selective, electrophilic fluorinations using N-fluoro-o- benzenedisulfonimide
-
Davis, F. A.; Han, W.; Murphy, C. K. Selective, electrophilic fluorinations using N-fluoro-o-benzenedisulfonimide. J. Org. Chem. 1995, 60 (15), 4730-4737
-
(1995)
J. Org. Chem.
, vol.60
, Issue.15
, pp. 4730-4737
-
-
Davis, F.A.1
Han, W.2
Murphy, C.K.3
-
26
-
-
0032444964
-
A facile synthesis of 2-substituted isoflavones for immunoassay: Assembly of the isoflavonoid skeleton by means of a novel cyclisation reaction
-
Pelter, A.; Ward, R. S.; Whalley, J. L. A facile synthesis of 2-substituted isoflavones for immunoassay: assembly of the isoflavonoid skeleton by means of a novel cyclisation reaction. Synthesis 1998, 12, 1793-1802.
-
(1998)
Synthesis
, vol.12
, pp. 1793-1802
-
-
Pelter, A.1
Ward, R.S.2
Whalley, J.L.3
-
27
-
-
0025974767
-
4-Hydroxy-3-methoxyflavones with potent antipicornavirus activity
-
De Meyer, N.; Haemers, A.; Mishra, L.; Pandey, H. K.; Pieters, L. A. C.; Vanden Berghe, D. A.; Vlietinck, A. J. 4-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. J. Med. Chem. 1991, 34 (2), 736-746.
-
(1991)
J. Med. Chem.
, vol.34
, Issue.2
, pp. 736-746
-
-
De Meyer, N.1
Haemers, A.2
Mishra, L.3
Pandey, H.K.4
Pieters, L.A.C.5
Vanden Berghe, D.A.6
Vlietinck, A.J.7
-
28
-
-
0002877822
-
A new synthesis of 3-chloroflavones
-
Newman, M. S.; Ferrari, J. L.; Garg, C. P. A new synthesis of 3-chloroflavones. J. Heterocycl. Chem. 1964, 1, 76-78.
-
(1964)
J. Heterocycl. Chem.
, vol.1
, pp. 76-78
-
-
Newman, M.S.1
Ferrari, J.L.2
Garg, C.P.3
-
29
-
-
0029134681
-
Synthesis and antiaggregator activity of some new derivatives of 4H-1-benzopyran-4-one
-
Goker, H.; Ayhan, G.; Tuncbilek, M.; Ertan, R.; Leoncini, G.; Garzoglio, R.; Mazzei, M. Synthesis and antiaggregator activity of some new derivatives of 4H-1-benzopyran-4-one. Eur. J. Med. Chem. 1995, 30, 561-567.
-
(1995)
Eur. J. Med. Chem.
, vol.30
, pp. 561-567
-
-
Goker, H.1
Ayhan, G.2
Tuncbilek, M.3
Ertan, R.4
Leoncini, G.5
Garzoglio, R.6
Mazzei, M.7
-
31
-
-
37049153536
-
The formation of 2-methylbenzimidazoles
-
Phillips, M. A. The formation of 2-methylbenzimidazoles. J. Chem. Soc. 1928, 172-177.
-
(1928)
J. Chem. Soc.
, pp. 172-177
-
-
Phillips, M.A.1
-
32
-
-
0032580927
-
Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity
-
Goker, H.; Tuncbilek, M.; Ayhan, G.; Altanlar, N. Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity. Farmaco 1998, 53 (6), 415-420.
-
(1998)
Farmaco
, vol.53
, Issue.6
, pp. 415-420
-
-
Goker, H.1
Tuncbilek, M.2
Ayhan, G.3
Altanlar, N.4
-
33
-
-
0034175574
-
Solid-phase synthesis of branched thiohydantoin tetrahydroquinoxalinediones
-
Nefzi, A.; Giulianotti, M. A.; Houghten, R. A. Solid-phase synthesis of branched thiohydantoin tetrahydroquinoxalinediones. Tetrahedron Lett. 2000, 41 (14), 2283-2287.
-
(2000)
Tetrahedron Lett.
, vol.41
, Issue.14
, pp. 2283-2287
-
-
Nefzi, A.1
Giulianotti, M.A.2
Houghten, R.A.3
-
34
-
-
0042674370
-
A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent
-
Asai, A.; Oshima, Y.; Yamamoto, Y.; Uochi, T.; Kusaka, H.; Akinaga, S.; Yamashita, Y.; Pongracz, K.; Pruzan, R.; Wunder, E.; Piatyszek, M.; Li, S.; Chin, A. C.; Harley, C. B.; Gryaznov, S. A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent. Cancer Res. 2003, 63 (14), 3931-3939.
-
(2003)
Cancer Res.
, vol.63
, Issue.14
, pp. 3931-3939
-
-
Asai, A.1
Oshima, Y.2
Yamamoto, Y.3
Uochi, T.4
Kusaka, H.5
Akinaga, S.6
Yamashita, Y.7
Pongracz, K.8
Pruzan, R.9
Wunder, E.10
Piatyszek, M.11
Li, S.12
Chin, A.C.13
Harley, C.B.14
Gryaznov, S.15
-
35
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W.; Piatyszek, M. A.; Prowse, K. R.; Harley, C. B.; West, M. D.; Ho, P. L. C.; Coviello, G. M.; Wright, W. E.; Weinrich, S. L.; Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266, 2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.C.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
36
-
-
0034662616
-
2-5A Antisense telomerase RNA therapy for intracranial malignant gliomas
-
Mukai, S.; Kondo, Y.; Koga, S.; Komata, T.; Barna, B. P.; Kondo, S. 2-5A Antisense telomerase RNA therapy for intracranial malignant gliomas. Cancer Res. 2000, 60 (16), 4461-4467.
-
(2000)
Cancer Res.
, vol.60
, Issue.16
, pp. 4461-4467
-
-
Mukai, S.1
Kondo, Y.2
Koga, S.3
Komata, T.4
Barna, B.P.5
Kondo, S.6
-
37
-
-
0026002989
-
Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands
-
Kotic, S.; Soskic, V.; Joksimovic, J. Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands. Bioorg. Med. Chem. Lett. 1991, 1 (8), 403-406.
-
(1991)
Bioorg. Med. Chem. Lett.
, vol.1
, Issue.8
, pp. 403-406
-
-
Kotic, S.1
Soskic, V.2
Joksimovic, J.3
-
38
-
-
0017911537
-
Synthesis and adrenergic activity of benzimidazole bioisosteres of norepinephrine and isoproterenol
-
Arnett, C. D.; Wright, J.; Zenker, N. Synthesis and adrenergic activity of benzimidazole bioisosteres of norepinephrine and isoproterenol. J. Med. Chem. 1978, 21, 72-78.
-
(1978)
J. Med. Chem.
, vol.21
, pp. 72-78
-
-
Arnett, C.D.1
Wright, J.2
Zenker, N.3
-
39
-
-
0035352382
-
DNA Tetraplex-binding drugs structure-selective targeting is critical for antitumor telomerase inhibition
-
Perry, P. J.; Jenkins, T. C. DNA Tetraplex-binding drugs structure-selective targeting is critical for antitumor telomerase inhibition. Mini Rev. Med. Chem. 2001, 1 (1), 31-41.
-
(2001)
Mini Rev. Med. Chem.
, vol.1
, Issue.1
, pp. 31-41
-
-
Perry, P.J.1
Jenkins, T.C.2
-
40
-
-
0032514479
-
1,4- and 2,6-Disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase
-
Perry, P. J.; Gowan, S. M.; Reszka, A. P.; Polucci, P.; Jenkins, T. C.; Kelland, R. L.; Neidle, S. 1,4- and 2,6-Disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. J. Med. Chem. 1998, 41, 3253-3260.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3253-3260
-
-
Perry, P.J.1
Gowan, S.M.2
Reszka, A.P.3
Polucci, P.4
Jenkins, T.C.5
Kelland, R.L.6
Neidle, S.7
-
41
-
-
0033812999
-
A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b] quinoline
-
Caprio, V.; Guyen, B.; Opoku-Boahen, Y.; Mann, J.; Gowan, S. M.; Kelland, L. M.; Read, M. A.; Neidle, S. A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline. Bioorg. Med. Chem. Lett. 2000, 10 (18), 2063-2066.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, Issue.18
, pp. 2063-2066
-
-
Caprio, V.1
Guyen, B.2
Opoku-Boahen, Y.3
Mann, J.4
Gowan, S.M.5
Kelland, L.M.6
Read, M.A.7
Neidle, S.8
|