Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia

Biological Psychiatry

Volumn 56, Issue 12, 2004, Pages 943-950

  Pongrac, Julie L ^a   Middleton, Frank A ^b   Peng, Lansha ^c   Lewis, David A ^a   Levitt, Pat ^a   Mirnics, Károly ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

chaperone; gene expression; haloperidol; in situ hybridization; Microarray; postmortem

Indexed keywords

BENZATROPINE MESILATE; HALOPERIDOL DECANOATE; HEAT SHOCK PROTEIN; MESSENGER RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MAJOR DEPRESSION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OCCIPITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE;

ADULT; ANIMALS; ANTIPSYCHOTIC AGENTS; BLOTTING, NORTHERN; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE EXPRESSION REGULATION; HALOPERIDOL; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IN SITU HYBRIDIZATION; MACACA FASCICULARIS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POSTMORTEM CHANGES; PREFRONTAL CORTEX; RNA, MESSENGER; SCHIZOPHRENIA; SEQUENCE HOMOLOGY, AMINO ACID; STAINING AND LABELING;

EID: 10444287637     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2004.09.005     Document Type: Article

References (58)

1. S.F. Altschul, T.L. Madden, A.A. Schaffer, J. Zhang, Z. Zhang, W. Miller Gapped BLAST and PSI-BLAST A new generation of protein database search programs Nucleic Acids Res 25 1997 3389 3402
2. L.M. Brzustowicz, J.E. Hayter, K.A. Hodgkinson, E.W. Chow, A.S. Bassett Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22 Hum Hered 54 2002 199 209
3. A. Bergman, M.L. Siegal Evolutionary capacitance as a general feature of complex gene networks Nature 424 2003 549 552
4. B. Bukau, A.L. Horwich The Hsp70 and Hsp60 chaperone machines Cell 92 1998 351 366
5. V. Calabrese, G. Scapagnini, A. Ravagna, A.M. Giuffrida Stella, D.A. Butterfield Molecular chaperones and their roles in neural cell differentiation Dev Neurosci 24 2002 1 13
6. D.B. Campbell, J.B. North, E. Hess Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background Exp Neurol 160 1999 268 278
7. W.T. Carpenter Jr, R.W. Buchanan Schizophrenia N Engl J Med 330 1994 681 690
8. H. Ewald, T.J. Flint, T.H. Jorgensen, A.G. Wang, P. Jensen, M. Vang Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands Am J Med Genet 114 2002 196 204
9. M. Fountoulakis, J.F. Juranville, M. Dierssen, G. Lubec Proteomic analysis of the fetal brain Proteomics 2 2002 1547 1576
10. J. Gabriele, K. Culver, S. Sharma, B. Zhang, H. Szechtman, R. Mishra Asymmetric modulation of a catecholamine-regulated protein in the rat brain, following quinpirole administration Synapse 49 2003 261 269
11. A. Garcia-Osta, D. Frechilla, J. Del Rio Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone Prog Neuropsychopharmacol Biol Psychiatry 27 2003 31 36
12. Gottesman II Schizophrenia Genesis The Origins of Madness 1991 Freeman New York
13. Y. Hakak, J.R. Walker, C. Li, W.H. Wong, K.L. Davis, J.D. Buxbaum Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia Proc Natl Acad Sci U S A 98 2001 4746 4751
14. Z. Han, Q.A. Truong, S. Park, J.L. Breslow Two Hsp70 family members expressed in atherosclerotic lesions Proc Natl Acad Sci U S A 100 2003 1256 1261
15. P.J. Harrison, P.R. Heath, S.L. Eastwood, P.W. Burnet, B. McDonald, R.C. Pearson The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies selective mRNA vulnerability and comparison with their encoded proteins Neurosci Lett 200 1995 151 154
16. K. Hashimoto, S. Tomitaka, N. Narita, Y. Minabe, M. Iyo, S. Fukui Induction of heat shock protein (HSP)-70 in posterior cingulate and retrosplenial cortex of rat brain by dizocilpine and phencyclidine Lack of protective effects of sigma receptor ligands Addict Biol 1 1996 61 70
17. J. Hohfeld, D.M. Cyr, C. Patterson From the cradle to the grave Molecular chaperones that may choose between folding and degradation EMBO Rep 2 2001 885 890
18. C.C. Hsu, K.M. Davis, H. Jin, T. Foos, E. Floor, W. Chen Association of L-glutamic acid decarboxylase to the 70-kDa heat shock protein as a potential anchoring mechanism to synaptic vesicles J Biol Chem 275 2000 20822 20828
19. J.R. Kelsoe, M.A. Spence, E. Loetscher, M. Foguet, A.D. Sadovnick, R.A. Remick A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22 Proc Natl Acad Sci U S A 98 2001 585 590
20. K. Kilidireas, N. Latov, D.H. Strauss, A.D. Gorig, G.A. Hashim, J.M. Gorman Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia Lancet 340 1992 569 572
21. J.J. Kim, S.J. Lee, K.Y. Toh, C.U. Lee, C. Lee, I.H. Paik Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia Schizophr Res 52 2001 127 135
22. C.M. Lewis, D.F. Levinson, L.H. Wise, L.E. DeLisi, R.E. Straub, I. Hovatta Genome scan meta-analysis of schizophrenia and bipolar disorder, part II Schizophrenia Am J Hum Genet 73 2003 34 48
23. D.A. Lewis, J.A. Lieberman Catching up on schizophrenia Natural history and neurobiology Neuron 28 2000 325 334
24. D.A. Lewis, J.N. Pierri, D.W. Volk, D.S. Melchitzky, T.U. Woo Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia Biol Psychiatry 46 1999 616 626
25. D.A. Lewis, D.W. Volk, T. Hashimoto Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia A novel target for the treatment of working memory dysfunction Psychopharmacology (Berl) 174 2004 143 150
26. I. Leykin, B. Spivak, A. Weizman, I.R. Cohen, M. Shinitzky Elevated cellular immune response to human heat-shock protein-60 in schizophrenic patients Eur Arch Psychiatry Clin Neurosci 249 1999 238 246
27. D.J. Lockhart, H. Dong, M.C. Byrne, M.T. Follettie, M.V. Gallo, M.S. Chee Expression monitoring by hybridization to high-density oligonucleotide arrays Nat Biotechnol 14 1996 1675 1680
28. E.R. Marcotte, L.K. Srivastava, R. Quirion DNA microarrays in neuropsychopharmacology Trends Pharmacol Sci 22 2001 426 436
29. F.A. Middleton, K. Mirnics, J.N. Pierri, D.A. Lewis, P. Levitt Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia J Neurosci 22 2002 2718 2729
30. M.L. Mimmack, M. Ryan, H. Baba, J. Navarro-Ruiz, S. Iritani, R.L. Faull Gene expression analysis in schizophrenia Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22 Proc Natl Acad Sci U S A 99 2002 4680 4685
31. K. Mirnics Microarrays in brain research Data quality and limitations Current Genomics 3 2002 13 19
32. K. Mirnics, D.A. Lewis Genes and subtypes of schizophrenia Trends Mol Med 7 2001 281 283
33. K. Mirnics, F. Middleton, A. Marquez, D. Lewis, P. Levitt Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex Neuron 28 2000 53 67
34. K. Mirnics, F. Middleton, G. Stanwood, D. Lewis, P. Levitt Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia Mol Psychiatry 6 2000 293 301
35. K. Mirnics, F.A. Middleton, D.A. Lewis, P. Levitt Analysis of complex brain disorders with microarrays Schizophrenia as a disease of the synapse Trends Neurosci 24 2001 479 486
36. B.J. Mowry, K.R. Ewen, D.J. Nancarrow, D.P. Lennon, D.A. Nertney, H.L. Jones Second stage of a genome scan of schizophrenia Study of five positive regions in an expanded sample Am J Med Genet 96 2000 864 869
37. H. Murakami, D. Pain, G. Blobel 70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria J Cell Biol 107 1988 2051 2057
38. T. Nakahara, T. Kuroki, H. Hondo, T. Tsutsumi, K. Fukuda, H. Yao Effects of atypical antipsychotic drugs vs haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats Brain Res Mol Brain Res 73 1999 193 197
39. N. Okamura, K. Hashimoto, N. Kanahara, E. Shimizu, C. Kumakiri, N. Komatsu Protective effect of the antipsychotic drug zotepine on dizocilpine-induced neuropathological changes in rat retrosplenial cortex Eur J Pharmacol 461 2003 93 98
40. A. Parcellier, S. Gurbuxani, E. Schmitt, E. Solary, C. Garrido Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways Biochem Biophys Res Commun 304 2003 505 512
41. J.N. Pierri, A.S. Chaudry, T.U. Woo, D.A. Lewis Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects Am J Psychiatry 156 1999 1709 1719
42. J. Pongrac, F.A. Middleton, D.A. Lewis, P. Levitt, K. Mirnics Gene expression profiling with DNA microarrays Advancing our understanding of psychiatric disorders Neurochem Res 27 2002 1049 1063
43. S.L. Rutherford, S. Lindquist Hsp90 as a capacitor for morphological evolution Nature 396 1998 336 342
44. M. Schena, D. Shalon, R.W. Davis, P.O. Brown Quantitative monitoring of gene expression patterns with a complementary DNA microarray Science 270 1995 467 470
45. M.J. Schwarz, M. Riedel, R. Gruber, M. Ackenheil, N. Muller Antibodies to heat shock proteins in schizophrenic patients Implications for the mechanism of the disease Am J Psychiatry 156 1999 1103 1104
46. F.R. Sharp, M. Butman, J. Koistinaho, K. Aardalen, R. Nakki, S.M. Massa Phencyclidine induction of the hsp 70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels Neuroscience 62 1994 1079 1092
47. F.R. Sharp, M. Butman, S. Wang, J. Koistinaho, S.H. Graham, S.M. Sagar Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801 and ketamine J Neurosci Res 33 1992 605 616
48. S. Takayama, J.C. Reed, S. Homma Heat-shock proteins as regulators of apoptosis Oncogene 22 2003 9041 9047
49. H. Tomita, M.P. Vawter, D.M. Walsh, S.J. Evans, P.V. Choudary, J. Li Effect of agonal and postmortem factors on gene expression profile quality control in microarray analyses of postmortem human brain Biol Psychiatry 55 2004 346 352
50. D. Tkachev, M.L. Mimmack, M.M. Ryan, M. Wayland, T. Freeman, P.B. Jones Oligodendrocyte dysfunction in schizophrenia and bipolar disorder Lancet 362 2003 798 805
51. M.P. Vawter, J.M. Crook, T.M. Hyde, J.E. Kleinman, D.R. Weinberger, K.G. Becker Microarray analysis of gene expression in the prefrontal cortex in schizophrenia A preliminary study Schizophr Res 58 2002 11 20
52. D.V. Volk, M.C. Austin, J.N. Pierri, R.A. Sampson, D.A. Lewis Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia Arch Gen Psychiatry 57 2000 237 245
53. D.W. Volk, M.C. Austin, J.N. Pierri, A.R. Sampson, D.A. Lewis Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia Arch Gen Psychiatry 57 2000 237 245
54. D.W. Volk, D.A. Lewis Impaired prefrontal inhibition in schizophrenia Relevance for cognitive dysfunction Physiol Behav 77 2002 501 505
55. W. Voos, K. Rottgers Molecular chaperones as essential mediators of mitochondrial biogenesis Biochim Biophys Acta 1592 2002 51 62
56. X.F. Wang, D. Wang, W. Zhu, K.K. Delrahim, D. Dolnak, M.H. Rapaport Studies characterizing 60 kda autoantibodies in subjects with schizophrenia Biol Psychiatry 53 2003 361 375
57. D.R. Weinberger From neuropathology to neurodevelopment Lancet 346 1995 552 557
58. D.L. Wheeler, D.M. Church, R. Edgar, S. Federhen, W. Helmberg, T.L. Madden Database resources of the National Center for Biotechnology Information Update Nucleic Acids Res 32 Database issue 2004 D35 D40