-
3
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21: 2787-99.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
6
-
-
2342492317
-
Review of epidermal growth factor receptor biology
-
Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 2004; 59: 21-6.
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.59
, pp. 21-26
-
-
Herbst, R.S.1
-
7
-
-
0033599039
-
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
-
Prenzel N, Zwick E, Daub H et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402: 884-8.
-
(1999)
Nature
, vol.402
, pp. 884-888
-
-
Prenzel, N.1
Zwick, E.2
Daub, H.3
-
8
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 1997; 16: 1647-55.
-
(1997)
EMBO J.
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
9
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
-
Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999; 68: 965-1014.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
10
-
-
0027530832
-
Effects of EGF, bFGF, NGF and PDGF (bb) on cell proliferative, migratory and invasive capacities of human brain-tumour biopsies in vitro
-
Engebraaten O, Bjerkvig R, Pedersen PH, Laerum OD, Effects of EGF, bFGF, NGF and PDGF (bb) on cell proliferative, migratory and invasive capacities of human brain-tumour biopsies in vitro. Int J Cancer 1993; 53: 209-14.
-
(1993)
Int. J. Cancer
, vol.53
, pp. 209-214
-
-
Engebraaten, O.1
Bjerkvig, R.2
Pedersen, P.H.3
Laerum, O.D.4
-
11
-
-
0029878429
-
Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth
-
Shibata T, Kawano T, Nagayasu H et al. Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth. Tumour Biol 1996; 17: 168-75.
-
(1996)
Tumour Biol.
, vol.17
, pp. 168-175
-
-
Shibata, T.1
Kawano, T.2
Nagayasu, H.3
-
12
-
-
0035918858
-
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization
-
Lammering G, Hewit TH, Hawkins WT et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. J Natl Cancer Inst 2001; 93: 921-9.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 921-929
-
-
Lammering, G.1
Hewit, T.H.2
Hawkins, W.T.3
-
13
-
-
0034865816
-
Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor
-
Nagane M, Narita Y, Mishima K et al. Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor. J Neurosurg 2001; 95: 472-9.
-
(2001)
J. Neurosurg.
, vol.95
, pp. 472-479
-
-
Nagane, M.1
Narita, Y.2
Mishima, K.3
-
14
-
-
0028103920
-
Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures
-
Schmidt-Ullrich RK, Valerie KC, Chan W, McWilliams D. Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures. Int J Radiat Oncol Biol Phys 1994; 29: 813-9.
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.29
, pp. 813-819
-
-
Schmidt-Ullrich, R.K.1
Valerie, K.C.2
Chan, W.3
McWilliams, D.4
-
15
-
-
0038461104
-
Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs
-
Ciardiello F, Tortora G. Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer 2003; 39: 1348-54.
-
(2003)
Eur. J. Cancer
, vol.39
, pp. 1348-1354
-
-
Ciardiello, F.1
Tortora, G.2
-
16
-
-
0037296357
-
The epidermal growth factor receptor-tyrosine kinase: A promising therapeutic target in solid tumors
-
Ritter CA, Arteaga CL. The epidermal growth factor receptor-tyrosine kinase: a promising therapeutic target in solid tumors. Semin Oncol 2003; 30: 3-11.
-
(2003)
Semin. Oncol.
, vol.30
, pp. 3-11
-
-
Ritter, C.A.1
Arteaga, C.L.2
-
18
-
-
0034954124
-
The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
-
Pedersen MW, Meltorn M, Damstrup L, Poulsen HS. The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann Oncol 2001; 12: 745-60.
-
(2001)
Ann. Oncol.
, vol.12
, pp. 745-760
-
-
Pedersen, M.W.1
Meltorn, M.2
Damstrup, L.3
Poulsen, H.S.4
-
19
-
-
0036286452
-
Mutant epidermal growth factor receptors as targets for cancer therapy
-
Lorimer IA. Mutant epidermal growth factor receptors as targets for cancer therapy. Curr Cancer Drug Targets 2002; 2: 91-102.
-
(2002)
Curr. Cancer Drug Targets
, vol.2
, pp. 91-102
-
-
Lorimer, I.A.1
-
20
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J, Pfister D, Cooper MR et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000; 18: 904-14.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
-
21
-
-
16144362509
-
Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A
-
Ciardiello F, Damiano V, Bianco R et al. Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. J Natl Cancer Inst 1996; 88: 1770-6.
-
(1996)
J. Natl. Cancer Inst.
, vol.88
, pp. 1770-1776
-
-
Ciardiello, F.1
Damiano, V.2
Bianco, R.3
-
22
-
-
0010233988
-
Growth stimulation of A431 cells by epidermal growth factor: Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
-
Kawamoto T, Sato JD, Le A et al. Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci USA 1983; 80: 1337-41.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 1337-1341
-
-
Kawamoto, T.1
Sato, J.D.2
Le, A.3
-
23
-
-
0020933452
-
Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
-
Sato JD, Kawamoto T, Le AD et al. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1983; 1: 511-29.
-
(1983)
Mol. Biol. Med.
, vol.1
, pp. 511-529
-
-
Sato, J.D.1
Kawamoto, T.2
Le, A.D.3
-
24
-
-
0028116305
-
Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
-
Fan Z, Lu Y, Wu X, Mendelsohn J. Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 1994; 269: 27595-602.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27595-27602
-
-
Fan, Z.1
Lu, Y.2
Wu, X.3
Mendelsohn, J.4
-
25
-
-
0029670014
-
Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
-
Wu X, Rubin M, Fan Z et al. Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 1996; 12: 1397-403.
-
(1996)
Oncogene
, vol.12
, pp. 1397-1403
-
-
Wu, X.1
Rubin, M.2
Fan, Z.3
-
26
-
-
0032572699
-
Nuclear targeting of Bax during apoptosis in human colorectal cancer cells
-
Mandal M, Adam L, Mendelsohn J, Kumar R. Nuclear targeting of Bax during apoptosis in human colorectal cancer cells. Oncogene 1998; 17: 999-1007.
-
(1998)
Oncogene
, vol.17
, pp. 999-1007
-
-
Mandal, M.1
Adam, L.2
Mendelsohn, J.3
Kumar, R.4
-
27
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Peth AM, Rak J, Hung MC et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 1997; 151: 1523-30.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1523-1530
-
-
Peth, A.M.1
Rak, J.2
Hung, M.C.3
-
28
-
-
0003018496
-
Blockade of EGF-R signalling with anti-EGFR monoclonal antibody (Mb) C225 inhibits matrix metalloproteinase-9 (MMP-9) expression and invasion of human transitional cell carcinoma (tCC) in vitro and in vivo
-
(Abstract)
-
Matsumoto T, Perrotte P, Bar-Eli M et al. Blockade of EGF-R signalling with anti-EGFR monoclonal antibody (Mb) C225 inhibits matrix metalloproteinase-9 (MMP-9) expression and invasion of human transitional cell carcinoma (tCC) in vitro and in vivo. Proc Am Assoc Cancer Res 1998; 39: 83 (Abstract).
-
(1998)
Proc. Am. Assoc. Cancer Res.
, vol.39
, pp. 83
-
-
Matsumoto, T.1
Perrotte, P.2
Bar-Eli, M.3
-
29
-
-
0027290650
-
Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
-
Baselga J, Norton L, Masui H et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 1993; 85: 1327-33.
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 1327-1333
-
-
Baselga, J.1
Norton, L.2
Masui, H.3
-
30
-
-
0027428571
-
Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
-
Fan Z, Baselga J, Masui H, Mendelsohn J. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 1993; 53: 4637-42.
-
(1993)
Cancer Res.
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
Mendelsohn, J.4
-
31
-
-
0033966576
-
In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody
-
Milas L, Mason K, Hunter N et al. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 2000; 6: 701-8.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 701-708
-
-
Milas, L.1
Mason, K.2
Hunter, N.3
-
32
-
-
0036094194
-
Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
-
Prewett MC, Hooper AT, Bassi R et al. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res 2002; 8: 994-1003.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 994-1003
-
-
Prewett, M.C.1
Hooper, A.T.2
Bassi, R.3
-
33
-
-
0034895886
-
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
-
Shin DM, Donato NJ, Perez-Soler R et al. Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res 2001; 7: 1204-13.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1204-1213
-
-
Shin, D.M.1
Donato, N.J.2
Perez-Soler, R.3
-
34
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201-8.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
-
35
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor (EGFR)
-
(Abstract 7)
-
Saltz LB, Hochester H, Rubin M et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor (EGFR). Proc Am Soc Clin Oncol 2001; 20: 3a (Abstract 7).
-
(2001)
Proc. Am. Soc. Clin. Oncol.
, vol.20
-
-
Saltz, L.B.1
Hochester, H.2
Rubin, M.3
-
36
-
-
0037862765
-
Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC)
-
(Abstract 1012)
-
Cunningham D, Humbler Y, Siena S et al. Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2003; 22: 252a (Abstract 1012).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
-
-
Cunningham, D.1
Humbler, Y.2
Siena, S.3
-
37
-
-
0344773402
-
The presence and intensity of the cetuximab-induced acne-like rash predicts survival in studies across multiple malignancies
-
(Abstract 817)
-
Saltz LB, Kies J, Abbruzzese N et al. The presence and intensity of the cetuximab-induced acne-like rash predicts survival in studies across multiple malignancies. Proc Am Soc Clin Oncol 2003; 22: 204 (Abstract 817).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 204
-
-
Saltz, L.B.1
Kies, J.2
Abbruzzese, N.3
-
38
-
-
0037531121
-
Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III trial
-
Rothenberg ML, Oza AM, Bigelow RH et al. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a phase III trial. J Clin Oncol 2003; 21: 2059-69.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2059-2069
-
-
Rothenberg, M.L.1
Oza, A.M.2
Bigelow, R.H.3
-
39
-
-
3543053772
-
Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin
-
(Abstract 3510)
-
Lenz H-J, Mayer R, Gold P et al. Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. Proc Am Soc Clin Oncol 2004; 23: 248 (Abstract 3510).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 248
-
-
Lenz, H.-J.1
Mayer, R.2
Gold, P.3
-
40
-
-
0012722459
-
Cetuximab (C225) plus irinotecan (CPT-11) plus infusional 5-FU-folinic acid (FA) is safe and active in metastatic colorectal cancer (MCRC), that expresses epidermal growth factor receptor (EGFR)
-
(Abstract 633)
-
Schoffski P, Lutz M, Folprecht G et al. Cetuximab (C225) plus irinotecan (CPT-11) plus infusional 5-FU-folinic acid (FA) is safe and active in metastatic colorectal cancer (MCRC), that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002; 21 159a (Abstract 633).
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, vol.21
-
-
Schoffski, P.1
Lutz, M.2
Folprecht, G.3
-
41
-
-
16244372110
-
Cetuximab + folfiri as first-line treatment for metastatic colorectal cancer CA
-
(Abstract 3513)
-
Rougier P, Raoul J, Van Laethem J et al. Cetuximab + folfiri as first-line treatment for metastatic colorectal cancer CA. Proc Am Soc Clin Oncol 2004; 23: 248 (Abstract 3513).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 248
-
-
Rougier, P.1
Raoul, J.2
Van Laethem, J.3
-
42
-
-
6444243519
-
An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU) /folinic acid (FA) (Folfox-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results
-
(Abstract 3512)
-
Tabernero J, Van Cutsem E, Sastre J et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU) /folinic acid (FA) (Folfox-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results. Proc Am Soc Clin Oncol 2004; 23: 248 (Abstract 3512).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 248
-
-
Tabernero, J.1
Van Cutsem, E.2
Sastre, J.3
-
43
-
-
0242437303
-
Concurrent cetuximab, cisplatin, and concomitant boost radiation therapy (RT) for locoregionally advanced, squamous cell head and neck cancer (SCCHN): Preliminary evaluation of a new combined-modality paradigm
-
(Abstract 1993)
-
Pfister D, Aliff T, Kraus D et al. Concurrent cetuximab, cisplatin, and concomitant boost radiation therapy (RT) for locoregionally advanced, squamous cell head and neck cancer (SCCHN): Preliminary evaluation of a new combined-modality paradigm. Proc Am Soc Clin Oncol 2003; 22: 495 (Abstract 1993).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 495
-
-
Pfister, D.1
Aliff, T.2
Kraus, D.3
-
44
-
-
0035398021
-
Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
-
Robert F, Ezekiel MP, Spencer SA et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol 2001; 19: 3234-43.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 3234-3243
-
-
Robert, F.1
Ezekiel, M.P.2
Spencer, S.A.3
-
45
-
-
10444220480
-
Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab
-
(Abstract 5507)
-
Bonner J, Giralt P, Harari R et al. Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab. Proc Am Soc Clin Oncol 2004 (Abstract 5507).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
-
-
Bonner, J.1
Giralt, P.2
Harari, R.3
-
46
-
-
0001413605
-
Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head and neck cancer (HNC)
-
(Abstract 901)
-
Burtness B, Li Y, Flood W et al. Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head and neck cancer (HNC). Proc Am Soc Clin Oncol 2002; 21: 226a (Abstract 901).
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, vol.21
-
-
Burtness, B.1
Li, Y.2
Flood, W.3
-
47
-
-
0001407134
-
Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum-based regimen
-
(Abstract 900)
-
Baselga J, Trigo J, Bourhis J et al. Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum-based regimen. Proc Am Soc Clin Oncol 2002; 21: 226a (Abstract 900).
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, vol.21
-
-
Baselga, J.1
Trigo, J.2
Bourhis, J.3
-
48
-
-
9744266972
-
Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): Results of a phase II study
-
(Abstract 5502)
-
Trigo J, Hitt R, Koralewski R et al. Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): Results of a phase II study. Proc Am Soc Clin Oncol 2004; 23: 487 (Abstract 5502).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 487
-
-
Trigo, J.1
Hitt, R.2
Koralewski, R.3
-
49
-
-
0038140036
-
A multicenter phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer
-
(Abstract 2592)
-
Kelly K, Hanna N, Rosenberg A et al. A multicenter phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer. Proc Am Soc Clin Oncol 2003; 23: 644 (Abstract 2592).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 644
-
-
Kelly, K.1
Hanna, N.2
Rosenberg, A.3
-
50
-
-
0038140033
-
Cetuximab (C225) in combination with cisplatin/vinorelbine vs cisplatin/vinorelbine alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR) positive advanced non-small-cell-lung cancer (NSCLC)
-
(Abstract 2582)
-
Gatzemeier U, Rosell R, Ramlau R et al. Cetuximab (C225) in combination with cisplatin/vinorelbine vs cisplatin/vinorelbine alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR) positive advanced non-small-cell-lung cancer (NSCLC). Proc Am Soc Clin Oncol 2003; 22: 642 (Abstract 2582).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 642
-
-
Gatzemeier, U.1
Rosell, R.2
Ramlau, R.3
-
51
-
-
33751580192
-
A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: Final report
-
(Abstract 2581)
-
Kim E, Mauser A, Tran H et al. A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: Final report. Proc Am Soc Clin Oncol 2003; 22: 642 (Abstract 2581).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 642
-
-
Kim, E.1
Mauser, A.2
Tran, H.3
-
52
-
-
4444325685
-
A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer
-
(Abstract 7084)
-
Lynch T, Lilenbaum R, Bonomi P et al. A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer. Proc Am Soc Clin Oncol 2004; 23: 634 (Abstract 7084).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 634
-
-
Lynch, T.1
Lilenbaum, R.2
Bonomi, P.3
-
53
-
-
14444288522
-
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
-
Huang HS, Nagane M, Mingbeil CK et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 1997; 272: 2927-35.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2927-2935
-
-
Huang, H.S.1
Nagane, M.2
Mingbeil, C.K.3
-
54
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350 2129-39.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
55
-
-
0036141447
-
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
-
Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002; 62: 200-7.
-
(2002)
Cancer Res.
, vol.62
, pp. 200-207
-
-
Chakravarti, A.1
Loeffler, J.S.2
Dyson, N.J.3
-
56
-
-
8344244132
-
Association of cyclin D1 (CCND1) gene A870G polymorphism and clinical outcome of EGFR-positive metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab (C225)
-
(Abstract 3518)
-
Zhang J, Press O, Gordon M et al. Association of cyclin D1 (CCND1) gene A870G polymorphism and clinical outcome of EGFR-positive metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab (C225). Proc Am Soc Clin Oncol 2004; 23: 250 (Abstract 3518).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
, pp. 250
-
-
Zhang, J.1
Press, O.2
Gordon, M.3
|