A nutrient sensor mechanism;Les mouches gardent la ligne: Slimfast, le corps gras et le contrôle humoral de la croissance

Medecine/Sciences

Volumn 20, Issue 2, 2004, Pages 141-143

  Colombani, Julien ^a   Arquier, Nathalie ^a   Léopold, Pierre ^a  

^a CENTRE DE BIOCHIMIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN; TARGET OF RAPAMYCIN KINASE;

DROSOPHILA; GENE EXPRESSION; LARVA; METAZOON; NONHUMAN; NOTE; NUTRIENT; RNA TRANSLATION; SENSOR;

METAZOA;

EID: 1042268696     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2004202141     Document Type: Note

References (11)

1. Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 2003; 4: 117-26.
2. Kimball SR, Jefferson LS. Regulation of translation initiation mammalian cells by amino acids. In: Sonenberg N, Mathews MB, eds. Translational control of gene expression. New York: Cold Spring Harbor Laboratory Press, 2000: 561-79.
3. Garofalo RS. Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol Metab 2002; 13: 156-62.
4. Oldham S, Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 2003; 13: 79-85.
5. Britton JS, Edgar BA. Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development 1998; 125: 2149-58.
6. Colombani J, Raisin S, Pantalacci S, Radimerski T, Montagne J, Léopold P. A nutrient sensor mechanism controls Drosophila growth. Cell 2003; 114: 739-49.
7. Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 2000; 14: 2689-94.
8. Zhang H, Stalloch JP, Ng JC, Reinhard C, Neufeld TP. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 2000; 14: 2712-24.
9. Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-life peptides in growth control. Curr Biol 2001; 11: 213-21.
10. Rulifson EJ, Kim SK, Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 2002; 296: 1118-20.
11. Boisclair YR, Rhoads RP, Uehi I, Wang J, Ooi GT. The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system. J Endocrinol 2001; 170: 63-70.