Difference in the Cardioprotective Mechanisms between Ischemic Preconditioning and Pharmacological Preconditioning by Diazoxide in Rat Hearts

Circulation Journal

Volumn 68, Issue 2, 2004, Pages 156-162

  Wakahara, Nobuyuki ^a   Katoh, Hideki ^a   Yaguchi, Yasuhiro ^a   Uehara, Akihiko ^a   Satoh, Hiroshi ^a   Terada, Hajime ^a   Fujise, Yutaka ^a   Hayashi, Hideharu ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ATP sensitive potassium channel; High energy phosphates; Intracellular pH; Mitochondria; Reactive oxygen species

Indexed keywords

5 HYDROXYDECANOIC ACID; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTIOXIDANT; DIAZOXIDE; PHOSPHATE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; REACTIVE OXYGEN METABOLITE;

ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEART INFARCTION PREVENTION; HEART MITOCHONDRION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HIGH ENERGY PHOSPHATE; MALE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CARDIOTONIC AGENTS; DIAZOXIDE; ENERGY METABOLISM; HYDROGEN-ION CONCENTRATION; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MAGNETIC RESONANCE IMAGING; MALE; MITOCHONDRIAL PROTEINS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; PHOSPHORUS ISOTOPES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 1042268124     PISSN: 13469843     EISSN: None     Source Type: Journal    
DOI: 10.1253/circj.68.156     Document Type: Article

References (44)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-1136.
2. O'Rourke B. Myocardial KATP channels in preconditioning. Circ Res 2000; 87: 845-855.
3. Gross GJ, Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992; 70: 223-233.
4. + channels. Possible mechanism of cardioprotection. Circ Res 1997; 81: 1072-1082.
5. Pain T, Yang XM, Critz SD, Yue Y, Nakano A, Liu GS, et al. Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals. Circ Res 2000; 87: 460-466.
6. Forbes RA, Steenbergen C, Murphy E. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res 2001; 88: 802-809.
7. Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 1998; 273: 18092-18098.
8. Yaguchi Y, Satoh H, Wakahara N, Katoh H, Uehara A, Terada H, et al. Protective effects of hydrogen peroxide against ischemia/reperfusion injury in perfused rat hearts. Circ J 2003; 67: 253-258.
9. Toombs CF, Moore TL, Shebuski RJ. Limitation of infarct size in the rabbit by ischaemic preconditioning is reversible with glibenclamide. Cardiovasc Res 1993; 27: 617-622.
10. Fryer RM, Eells JT, Hsu AK, Henry MM, Gross GJ. Ischemic preconditioning in rats: Role of mitochondrial KATP channel in preservation of mitochondrial function. Am J Physiol Heart Circ Physiol 2000; 278: H305-H312.
11. Tanaka M, Fujiwara H, Yamasaki K, Sasayama S. Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit. Cardiovasc Res 1994; 28: 980-986.
12. Chen W, Gabel S, Steenbergen C, Murphy E. A redox-based mechanism for cardioprotection induced by ischemic preconditioning in perfused rat heart. Circ Res 1995; 77: 424-429.
13. Grover GJ, Murray HN, Baird AJ, Dzwonczyk S. The KATP blocker sodium 5-hydroxydecanoate does not abolish preconditioning in isolated rat hearts. Eur J Pharmacol 1995; 277: 271-274.
14. Schwartz LM, Welch TS, Crago MS. Cardioprotection by multiple preconditioning cycles does not require mitochondrial KATP channels in pigs. Am J Physiol Heart Circ Physiol 2002; 283: H1538-H1544.
15. Lim KH, Javadov SA, Das M, Clarke SJ, Suleiman MS, Halestrap AP. The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration. J Physiol 2002; 545: 961-974.
16. Iwamoto T, Miura T, Adachi T, Noto T, Ogawa T, Tsuchida A, et al. Myocardial infarct size-limiting effect of ischemic preconditioning was not attenuated by oxygen free-radical scavengers in the rabbit. Circulation 1991; 83: 1015-1022.
17. Richard V, Tron C, Thuillez C. Ischaemic preconditioning is not mediated by oxygen derived free radicals in rats. Cardiovasc Res 1993; 27: 2016-2021.
18. Kida M, Fujiwara H, Ishida M, Kawai C, Ohura M, Miura I, et al. Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation 1991; 84: 2495-2503.
19. Asimakis GK, Inners-McBride K, Medellin G, Conti VR. Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat heart. Am J Physiol 1992; 263: H887-H894.
20. de Albuquerque CP, Gerstenblith G, Weiss RG. Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts. Circ Res 1994; 74: 139-150.
21. Dhalla NS, Elmoselhi AB, Hata T, Makino N. Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 2000; 47: 446-456.
22. Ozcan C, Bienengraeber M, Dzeja PP, Terzic A. Potassium channel openers protect cardiac mitochondria by attenuating: oxidant stress at reoxygenation. Am J Physiol Heart Circ Physiol 2002; 282: H531-H539.
23. + channel opening decreases reactive oxygen species generation. FEBS Lett 2003; 536: 51-55.
24. + channels reduces hydroxyl radicals in the rat myocardium. Arch Biochem Biophys 2000; 378: 195-200.
25. Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, et al. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res Cardiol 2002; 517: 365-373.
26. Klawitter PF, Murray HN, Clanton TL, Angelos MG. Reactive oxygen species generated during myocardial ischemia enable energetic recovery during reperfusion. Am J Physiol Heart Circ Physiol 2002; 283: H1656-H1661.
27. Lenaz G. The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology. IUBMB Life 2001; 52: 159-164.
28. Korshunov SS, Skulachev VP, Starkov AA. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 1997; 416: 15-18.
29. Crestanello JA, Doliba NM, Babsky AM, Niibori K, Osbakken MD, Whitman GJ. Mitochondrial function during ischemic preconditioning. Surgery 2002; 131: 172-178.
30. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 1990; 66: 913-931.
31. Kolocassides KG, Seymour AM, Galinanes M, Hearse DJ. Paradoxical effect of ischemic preconditioning on ischemic contracture? NMR studies of energy metabolism and intracellular pH in the rat heart. J Mol Cell Cardiol 1996; 28: 1045-1057.
32. Wolfe CL, Sievers RE, Visseren FL, Donnelly TJ. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 1993; 87: 881-892.
33. 31P NMR studies. J Mol Cell Cardiol 1997; 29: 1665-1673.
34. Dzeja PP, Bast P, Ozcan C, Valverde A, Holmuhamedov EL, Van Wylen DG, et al. Targeting nucleotide-requiring enzymes: Implications for diazoxide-induced cardioprotection. Am J Physiol Heart Circ Physiol 2003; 284: H1048-H1056.
35. Rouslin W, Broge CW, Grupp IL. ATP depletion and mitochondrial functional loss during ischemia in slow and fast heart-rate hearts. Am J Physiol 1990; 259: H1759-H1766.
36. Askenasy N. Glycolysis protects sarcolemmal membrane integrity during total ischemia in the rat heart. Basic Res Cardiol 2001; 96: 612-622.
37. Fukuda H, Luo CS, Gu X, Guo L, Digerness SB, Li J, et al. The effect of KATP channel activation on myocardial cationic and energetic status during ischemia and reperfusion: Role in cardioprotection. J Mol Cell Cardiol 2001; 33: 545-560.
38. Zimmer G, Freisleben HJ, Fuchs J. Influence of pH on sulfhydryl groups and fluidity of the mitochondrial membrane. Arch Biochem Biophys 1990; 282: 307-317.
39. Rouslin W. Mitochondrial complexes I, II, III, IV, and V in myocardial ischemia and autolysis. Am J Physiol 1983; 244: H743-H748.
40. 2+ overload in ischemic-reperfused rat hearts. Circ J 2002; 66: 390-396.
41. Halestrap AP, Kerr PM, Javadov S, Woodfield KY. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta 1998; 1366: 79-94.
42. King LM, Opie LH. Does preconditioning act by glycogen depletion in the isolated rat heart? J Mol Cell Cardiol 1996; 28: 2305-2321.
43. Opie LH, Sack MN Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J Mol Cell Cardiol 2002; 34: 1077-1089.
44. Sargent CA, Dzwonczyk S, Sleph P, Wilde M, Grover GJ. Pyruvate increases threshold for preconditioning in globally ischemic rat hearts. Am J Physiol 1994; 267: H1403-H1409.