IL-3 or IL-7 increases ex vivo gene transfer efficiency in ADA-SCID BM CD34+ cells while maintaining in vivo lymphoid potential

Molecular Therapy

Volumn 10, Issue 6, 2004, Pages 1096-1108

  Ficara, Francesca ^a   Superchi, Daniela B ^a   Hernández, Raisa Jofra ^a   Mocchetti, Cristina ^a   Carballido Perrig, Nicole ^b   Andolfi, Grazia ^a   Deola, Sara ^a   Colombo, Augusto ^c   Bordignon, Claudio ^a,d   Carballido, José M ^b   Roncarolo, Maria Grazia ^a,d   Aiuti, Alessandro ^a  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b NOVARTIS RESEARCH INSTITUTE   (Austria)

^c ICP   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

ADA SCID; Human stem progenitor cells; Immunodeficiency; Lymphoid differentiation

Indexed keywords

ADENOSINE DEAMINASE; CD34 ANTIGEN; FLT3 LIGAND; INTERLEUKIN 3; INTERLEUKIN 7; STEM CELL FACTOR; THROMBOPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CLINICAL PROTOCOL; CLONAL VARIATION; CLONE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DONOR; ENZYME DEFICIENCY; EX VIVO STUDY; GENE DELIVERY SYSTEM; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFUSION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROCESS OPTIMIZATION; PROGENY; PROLYMPHOCYTE; PURIFICATION; SCID MOUSE; STEM CELL; T LYMPHOCYTE;

ADENOSINE DEAMINASE; ANIMALS; ANTIGENS, CD34; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FETAL BLOOD; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; INTERLEUKIN-3; INTERLEUKIN-7; LYMPHOCYTES; MICE; MICE, SCID; SEVERE COMBINED IMMUNODEFICIENCY; STEM CELL TRANSPLANTATION; TRANSDUCTION, GENETIC;

ADA;

EID: 10344243971     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.08.014     Document Type: Article

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