Inhibitors of the mitotic kinesin spindle protein

Expert Opinion on Therapeutic Patents

Volumn 14, Issue 12, 2004, Pages 1659-1667

  Coleman, Paul J ^a   Fraley, Mark E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anti mitotic; Cancer; Kinesin spindle protein (KSP); Mitotic kinesin

Indexed keywords

1,2,4 TRIAZIN 5 ONE DERIVATIVE; 1,2,4 TRIAZOL 5 ONE DERIVATIVE; 2,5 DIHYDROPYRROLE DERIVATIVE; 4,5 DIHYDROPYRAZOLE DERIVATIVE; 7 CHLOROQUINAZOLINONE; ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CK 0106023; CREMOPHOR; DIHYDROPYRANCARBOXAMIDE DERIVATIVE; FURANOPYRIMIDINONE DERIVATIVE; ISPINESIB; KINESIN; KINESIN SPINDLE PROTEIN; KINESIN SPINDLE PROTEIN INHIBITOR; METHANE DERIVATIVE; MONASTROL; PACLITAXEL; PHENYLTHIAZINE DERIVATIVE; PTERIDINONE DERIVATIVE; PYRIMIDINONE DERIVATIVE; PYRIMIDOPYRIDAZINONE DERIVATIVE; PYRIMIDOPYRIMIDINE DERIVATIVE; PYRROLOTRIAZINONE DERIVATIVE; QUINAZOLINONE DERIVATIVE; TAXANE DERIVATIVE; TETRAHYDROPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCA ALKALOID;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; CLINICAL TRIAL; DISEASE MODEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MITOSIS SPINDLE; NEUROTOXICITY; NEUTROPENIA; NONHUMAN; PERIPHERAL NEUROPATHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; TUMOR CELL;

EID: 10344242934     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.14.12.1659     Document Type: Review

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