Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression

Journal of Endotoxin Research

Volumn 10, Issue 6, 2004, Pages 393-401

  Oberholzer, Caroline ^a   Oberholzer, Andreas ^a   Tschoeke, Sven K ^a   Minter, Rebecca M ^a   Bahjat, Frances R ^a   LaFace, Drake ^b   Hutchins, Beth ^b   Moldawer, Lyle L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Apoptosis; Cytokine; Gene therapy; Inflammation; Lipopolysaccharide

Indexed keywords

ADENOVIRUS VECTOR; GALACTOSAMINE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; GENE EXPRESSION; INFLAMMATION; LIVER INJURY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; GENE THERAPY; GENETIC VECTORS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES; MICE; MICE, INBRED C57BL; TUMOR NECROSIS FACTOR-ALPHA;

ADENOVIRIDAE;

EID: 10244263422     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805104225005832     Document Type: Article

References (30)

1. Huard J, Lochmuller H, Acsadi G, Jani A, Massie B, Karpati G. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Ther 1995; 2: 107-115.
2. Peeters MJ, Patijn GA, Lieber A, Meuse L, Kay MA. Adenovirus-mediated hepatic gene transfer in mice: comparison of intravascular and biliary administration. Hum Gene Ther 1996; 7 1693-1699.
3. Biron CA. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol 1994; 6 530-538.
4. Christ M, Lusky M, Stoeckel F et al. Gene therapy with recombinant adenovirus vectors: evaluation of the host immune response. Immunol Lett 1997; 57: 19-25.
5. Robbins PD, Ghivizzani SC. Viral vectors for gene therapy. Pharmacol Ther 1998; 80: 35-47.
6. Ginsberg HS, Horswood RL, Chanock RM, Prince GA. Role of early genes in pathogenesis of adenovirus pneumonia. Proc Natl Acad Sci USA 1990; 87: 6191-6195.
7. Muruve DA, Barnes MJ, Stillman IE, Libermann TA. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther 1999; 10: 965-976.
8. Ginsberg HS, Moldawer LL, Sehgal PB et al. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc Natl Acad Sci USA 1991; 88: 1651-1655.
9. Elkon KB, Liu CC, Gall JG et al. Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors. Proc Natl Acad Sci USA 1997; 94: 9814-9819.
10. Mignon A, Rouquet N, Fabre M et al. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med 1999; 159: 1308-1315.
11. Nowak M, Gaines GC, Rosenberg J et al. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor. Am J Physiol 2000; 278: R1202-R1209.
12. Wang JH, Redmond HP, Watson RW, Bouchier-Hayes D. Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis. Am J Physiol 1995; 269: G297-G304.
13. Wills KN, Maneval DC, Menzel P et al. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Hum Gene Ther 1994; 5: 1079-1088.
14. Graham FL, Prevec L. Methods for construction of adenovirus vectors. Mol Biotechnol 1995; 3: 207-220.
15. Minter RM, Rectenwald JE, Fukuzuka K et al. TNF-alpha receptor signaling and IL-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung. J Immunol 2000; 164: 443-451.
16. Minter RM, Ferry MA, Rectenwald JE et al. Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy. Proc Natl Acad Sci USA 2001; 98: 277-282.
17. Solorzano CC, Kaibara A, Hess PJ et al. Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon. J Appl Physiol 1998; 84: 1119-1130.
18. Espevik T, Nissen-Meyer J. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods 1986; 95: 99-105.
19. Galanos C, Freudenberg MA. Mechanisms of endotoxin shock and endotoxin hypersensitivity. Immunobiology 1993; 187: 346-356.
20. Leist M, Gantner F, Jilg S, Wendel A. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol 1995; 154: 1307-1316.
21. Lieber A, He CY, Meuse L et al. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J Virol 1997; 71: 8798-8807.
22. Alexander HR, Sheppard BC, Jensen JC et al. Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of Gram-negative sepsis. J Clin Invest 1991; 88: 34-39.
23. Alexander HR, Doherty GM, Block MI et al. Single-dose tumor necrosis factor protection against endotoxin-induced shock and tissue injury in rats. Infect Immun 1991; 59: 3889-3894.
24. Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996; 274: 782-784.
25. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996; 274: 787-789.
26. Iimuro Y, Nishiura T, Hellerbrand C et al. NF-kappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998; 101: 802-811.
27. Suzuki M, Suzuki S, Yamamoto N et al. Immune responses against replication-deficient adenovirus inhibit ovalbumin-specific allergic reactions in mice. Hum Gene Ther 2000; 11: 827-838.
28. Balachandran S, Roberts PC, Kipperman T et al. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. J Virol 2000; 74: 1513-1523.
29. Xing Z, Ohkawara Y, Jordana M, Graham FL, Gauldie J. Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Ther 1997; 4: 140-149.
30. Habib NA, Hodgson HJ, Lemoine N, Pignatelli M. A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours. Hum Gene Ther 1999; 10: 2019-2034.