Progesterone receptor isoform identification and subcellular localization in endometrial cancer

Gynecologic Oncology

Volumn 96, Issue 1, 2005, Pages 32-41

  Leslie, Kimberly K ^a   Stein, Mary Pat ^a   Kumar, Nirmala S ^b   Dai, Donghai ^a   Stephens, Janet ^b   Wandinger Ness, Angela ^a   Glueck, Deborah H ^b  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Endometrium; Estrogen; Human; Progesterone; Receptors; Trafficking; Uterus

Indexed keywords

PROGESTERONE RECEPTOR;

ARTICLE; CANCER CELL; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DISEASE ASSOCIATION; ENDOMETRIUM CARCINOMA; EPITHELIUM CELL; GENETIC IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEDICAL ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION;

ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; RECEPTORS, PROGESTERONE; SUBCELLULAR FRACTIONS;

EID: 10044290692     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygyno.2004.09.057     Document Type: Article

References (28)

1. I. Persson, H.O. Adami, L. Bergkvist, A. Lindgren, B. Pettersson, and R. Hoover Risk of endometrial cancer after treatment with oestrogens alone or in conjunction with progestogens: results of a prospective study BMJ 298 6667 1989 147 151
2. J.F. Savouret The progesterone receptor. Biological effects of progestins and antiprogestins Hum. Reprod. 9 Suppl 1 1994 7 11
3. J.F. Savouret, M. Rauch, G. Redeuilh, S. Sar, A. Chauchereau, and K. Woodruff Interplay between estrogens, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene J. Biol. Chem. 269 46 1994 28955 28962
4. K.B. Horwitz, and P.S. Alexander In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation Endocrinology 113 6 1983 2195 2201
5. N.L. Krett, L.L. Wei, M.D. Francis, S.K. Nordeen, D.F. Gordon, and W.M. Wood Human progesterone A-receptors can be synthesized intracellularly and are biologically functional Biochem. Biophys. Res. Commun. 157 1 1988 278 285
6. M.L.D. Graham, J.A. Smith, P.B. Jewett, and K.B. Horwitz Heterogeneity of progesterone receptor content and remodeling by tamoxifen characterize subpopulations of cultured human breast cancer cells: analysis by quantitative dual parameter flow cytometry Cancer Res. 52 3 1992 593 602
7. N.S. Kumar Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications for unopposed estrogen action Cancer Res. 58 9 1998 1860 1865
8. K.K. Leslie, N.S. Kumar, J. Richer, G. Owen, G. Takimoto, and K.B. Horwitz Differential expression of the A and B isoforms of progesterone receptor in human endometrial cancer cells. Only progesterone receptor B is induced by estrogen and associated with strong transcriptional activation Ann. N. Y. Acad. Sci. 828 1997 17 26
9. B.M. Jacobsen, J.K. Richer, S.A. Schittone, and K.B. Horwitz New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation J. Biol. Chem. 277 31 2002 27793 27800
10. E. Vegeto, M.M. Shahbaz, D.X. Wen, M.E. Goldman, B.W. O'Malley, and D.P. McDonnell Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function [see comments] Mol. Endocrinol. 7 10 1993 1244 1255
11. D. Dai, D.M. Wolf, E.S. Litman, M.J. White, and K.K. Leslie Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors Cancer Res. 62 3 2002 881 886
12. E. Smid-Koopman, L.J. Blok, L.C. Kuhne, C.W. Burger, T.J. Helmerhorst, and A.O. Brinkmann Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines J. Soc. Gynecol. Investig. 10 1 2003 49 57
13. R.L. Arnett-Mansfield, A. deFazio, G.V. Wain, R.C. Jaworski, K. Byth, and P.A. Mote Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium Cancer Res. 61 11 2001 4576 4582
14. J. Fujimoto, S. Ichigo, M. Hori, M. Nishigaki, and T. Tamaya Expression of progesterone receptor form A and B mRNAs in gynecologic malignant tumors Tumour Biol. 16 4 1995 254 260
15. B. Mulac-Jericevic, R.A. Mullinax, F.J. DeMayo, J.P. Lydon, and O.M. Conneely Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform Science 289 5485 2000 1751 1754
16. J.P. Lydon, F.J. DeMayo, C.R. Funk, S.K. Mani, A.R. Hughes, and C.A. Montgomery Jr. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities Genes Dev. 9 18 1995 2266 2278
17. P.A. Mote, J.F. Johnston, T. Manninen, P. Tuohimaa, and C.L. Clarke Detection of progesterone receptor forms A and B by immunohistochemical analysis J. Clin. Pathol. 54 8 2001 624 630
18. C.S. Lim, C.T. Baumann, H. Htun, W. Xian, M. Irie, and C.L. Smith Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimeras Mol. Endocrinol. 13 3 1999 366 375
19. D. Dai, N.S. Kumar, D.M. Wolf, and K.K. Leslie Molecular tools to reestablish progestin control of endometrial cancer cell proliferation Am. J. Obstet. Gynecol. 184 5 2001 790 797
20. C. Kanwal, H. Li, and C.S. Lim Model system to study classical nuclear export signals AAPS PharmSci. 4 3 2002 E18
21. V. Boonyaratanakornkit, M.P. Scott, V. Ribon, L. Sherman, S.M. Anderson, and J.L. Maller Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases Mol. Cell 8 2 2001 269 280
22. M. Qiu, A. Olsen, E. Faivre, K.B. Horwitz, and C.A. Lange Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors Mol. Endocrinol. 17 4 2003 628 642
23. C.A. Lange, T. Shen, and K.B. Horwitz Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome Proc. Natl. Acad. Sci. U. S. A. 97 3 2000 1032 1037
24. J.K. Richer, B.M. Jacobsen, N.G. Manning, M.G. Abel, D.M. Wolf, and K.B. Horwitz Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells J. Biol. Chem. 277 7 2002 5209 5218
25. A. Guiochon-Mantel, P. Lescop, S. Christin-Maitre, H. Loosfelt, M. Perrot-Applanat, and E. Milgrom Nucleocytoplasmic shuttling of the progesterone receptor EMBO J. 10 12 1991 3851 3859
26. J. Liu, and D.B. DeFranco Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway Mol. Endocrinol. 14 1 2000 40 51
27. M.D. Galigniana Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton Mol. Endocrinol. 12 12 1998 1903 1913
28. J. Liu, and D.B. DeFranco Chromatin recycling of glucocorticoid receptors: implications for multiple roles of heat shock protein 90 Mol. Endocrinol. 13 3 1999 355 365