Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines

Journal of the Society for Gynecologic Investigation

Volumn 10, Issue 1, 2003, Pages 49-57

  Smid Koopman, Ellen ^a   Blok, Leen J ^a   Kühne, Liesbeth C M ^a   Burger, Curt W ^a   Helmerhorst, Theo J M ^a   Brinkmann, Albert O ^a   Huikeshoven, Frans J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

cDNA expression array; Endometrial cancer; Genes; hPRA; hPRB

Indexed keywords

COMPLEMENTARY DNA; GESTAGEN; ISOPROTEIN; PROGESTERONE RECEPTOR; PROMEGESTONE; SOMATOMEDIN BINDING PROTEIN 3;

ARTICLE; CARCINOMA CELL; CELL ASSAY; CELL LINE; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; GENETIC TRANSFECTION; GROWTH REGULATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION;

CELL DIVISION; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEDROXYPROGESTERONE 17-ACETATE; PROGESTERONE; PROGESTERONE CONGENERS; PROMEGESTONE; RECEPTORS, PROGESTERONE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037223051     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(02)00217-4     Document Type: Article

References (40)

1. Curtis S.W., Clark J., Myers P., Korach K.S. Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus. Proc Natl Acad Sci U S A. 96:1999;3646-3651.
2. Quarmby V.E., Korach K.S. The influence of 17 beta-estradiol on patterns of cell division in the uterus. Endocrinology. 114:1984;694-702.
3. De M., Wood G.W. Influence of oestrogen and progesterone on macrophage distribution in the mouse uterus. J Endocrinol. 126:1990;417-424.
4. Martin L., Das R.M., Finn C.A. The inhibition by progesterone of uterine epithelial proliferation in the mouse. J Endocrinol. 57:1973;549-554.
5. Lydon J.P., DeMayo F.J., Funk C.R., et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9:1995;2266-2278.
6. Lydon J.P., DeMayo F.J., Conneely O.M., O'Malley B.W. Reproductive phenotypes of the progesterone receptor null mutant mouse. J Steroid Biochem Mol Biol. 56:1996;67-77.
7. Ehrlich C.E., Young P.C., Cleary R.E. Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria Therapeutic implications . Am J Obstet Gynecol. 141:1981;539-546.
8. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science. 240:1988;889-895.
9. Horwitz K.B., Alexander P.S. In situ photolinked nuclear progesterone receptors of human breast cancer cells Subunit molecular weights after transformation and translocation . Endocrinology. 113:1983;2195-2201.
10. Lessey B.A., Alexander P.S., Horwitz K.B. The subunit structure of human breast cancer progesterone receptors Characterization by chromatography and photoaffinity labeling . Endocrinology. 112:1983;1267-1274.
11. Meyer M.E., Gronemeyer H., Turcotte B., Bocquel M.T., Tasset D., Chambon P. Steroid hormone receptors compete for factors that mediate their enhancer function. Cell. 57:1989;433-442.
12. Vegeto E., Shahbaz M.M., Wen D.X., Goldman M.E., O'Malley B.W., McDonnell D.P. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol. 7:1993;1244-1255.
13. Kastner P., Krust A., Turcotte B., et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9:1990;1603-1614.
14. Graham J.D., Clarke C.L. Physiological action of progesterone in target tissues. Endocr Rev. 18:1997;502-519.
15. Kraus W.L., Weis K.E., Katzenellenbogen B.S. Determinants for the repression of estrogen receptor transcriptional activity by ligand-occupied progestin receptors. J Steroid Biochem Mol Biol. 63:1997;175-188.
16. Mote P.A., Balleine R.L., McGowan E.M., Clarke C.L. Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle. J Clin Endocrinol Metab. 84:1999;2963-2971.
17. Mulac-Jericevic B., Mullinax R.A., DeMayo F.J., Lydon J.P., Conneely O.M. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science. 289:2000;1751-1754.
18. Shyamala G., Yang X., Silberstein G., Barcellos-Hoff M.H., Dale E. Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands. Proc Natl Acad Sci U S A. 95:1998;696-701.
19. Graham J.D., Yeates C., Balleine R.L., et al. Characterization of progesterone receptor A and B expression in human breast cancer. Cancer Res. 55:1995;5063-5068.
20. Kumar N.S., Richer J., Owen G., Litman E., Horwitz K.B., Leslie K.K. Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells Implications for unopposed estrogen action . Cancer Res. 58:1998;1860-1865.
21. Tora L., Gronemeyer H., Turcotte B., Gaub M.P., Chambon P. The N-terminal region of the chicken progesterone receptor specifies target gene activation. Nature. 333:1988;185-188.
22. Nishida M., Kasahara K., Oki A., Satoh T., Arai Y., Kubo T. Establishment of eighteen clones of Ishikawa cells. Hum Cell. 9:1996;109-116.
23. Auffray C., Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem. 107:1980;303-314.
24. Blok L.J., Grossmann M.E., Perry J.E., Tindall D.J. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. Mol Endocrinol. 9:1995;1610-1620.
25. Chang G.T., Blok L.J., Steenbeek M., et al. Differentially expressed genes in androgen-dependent and -independent prostate carcinomas. Cancer Res. 57:1997;4075-4081.
26. Smid-Koopman E., Blok L.J., Chadha-Ajwani S., Helmerhorst T.J., Brinkmann A.O., Huikeshoven F.J. Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique Assessment of an analysis method . Br J Cancer. 83:2000;246-251.
27. Zava D.T., Landrum B., Horwitz K.B., McGuire W.L. Androgen receptor assay with methyltrienolone (R1881) in the presence of progesterone receptors. Endocrinology. 104:1979;1007-1019.
28. De Goeij A.F., Scheres H.M., Rousch M.J., Hondius G.G., Bosman F.T. Progesterone receptor quantification with radiolabeled promegestone (R 5020) in frozen sections of endometrium and breast cancer tissue. J Steroid Biochem. 29:1988;465-474.
29. Satyaswaroop P.G., Wartell D.J., Mortel R. Distribution of progesterone receptor, estradiol dehydrogenase, and 20 alpha-dihydroprogesterone dehydrogenase activities in human endometrial glands and stroma Progestin induction of steroid dehydrogenase activities in vitro is restricted to the glandular epithelium . Endocrinology. 111:1982;743-749.
30. Kester H.A., van der Leede B.M., van der Saag P.T., van der Burg B. Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. J Biol Chem. 272:1997;16637-16643.
31. Dai D., Kumar N.S., Wolf D.M., Leslie K.K. Molecular tools to reestablish progestin control of endometrial cancer cell proliferation. Am J Obstet Gynecol. 184:2001;790-797.
32. Fujimoto J., Ichigo S., Hori M., Nishigaki M., Tamaya T. Expression of progesterone receptor form A and B mRNAs in gynecologic malignant tumors. Tumour Biol. 16:1995;254-260.
33. Arnett-Mansfield R.L., deFazio A., Wain G.V., et al. Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium. Cancer Res. 61:2001;4576-4582.
34. Giovannucci E. Insulin-like growth factor-I and binding protein-3 and risk of cancer. Horm Res. 51:1999;34-41.
35. Yamanaka Y., Fowlkes J.L., Wilson E.M., Rosenfeld R.G., Oh Y. Characterization of insulin-like growth factor binding protein-3 (IGFBP- 3) binding to human breast cancer cells Kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule . Endocrinology. 140:1999;1319-1328.
36. Baxter R.C. Signalling pathways involved in antiproliferative effects of IGFBP-3 A review . Mol Pathol. 54:2001;145-148.
37. Butt A.J., Firth S.M., Baxter R.C. The IGF axis and programmed cell death. Immunol Cell Biol. 77:1999;256-262.
38. Grimberg A., Cohen P. Growth hormone and prostate cancer Guilty by association? J Endocrinol Invest. 22:1999;64-73.
39. Neuenschwander S., Schwartz A., Wood T.L., Roberts C.T. Jr, Henninghausen L., LeRoith D. Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. J Clin Invest. 97:1996;2225-2232.
40. Murphy L.J., Molnar P., Lu X., Huang H. Expression of human insulin-like growth factor-binding protein-3 in transgenic mice. J Mol Endocrinol. 15:1995;293-303.