A model membrane protein for binding volatile anesthetics

Biophysical Journal

Volumn 87, Issue 6, 2004, Pages 4065-4074

  Ye, Shixin ^a   Strzalka, Joseph ^a   Churbanova, Inna Y ^a   Zheng, Songyan ^a   Johansson, Jonas S ^a   Blasie, J Kent ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; HALOTHANE; INHALATION ANESTHETIC AGENT; ION CHANNEL; MEMBRANE PROTEIN; RECEPTOR PROTEIN;

ARTICLE; BINDING AFFINITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SPECIFICITY; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 10044264645     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.104.051045     Document Type: Article

References (45)

1. Als-Nielsen, J., and P. S. Pershan. 1983. Synchrotron x-ray-diffraction study of liquid surfaces. Nucl. Instrum. Methods. 208:545-548.
2. Blasie, J. K., and P. Timmins. 1999. Neutron scattering in structural biology and biomolecular materials. MRS Bull. 24:40-47.
3. Braslau, A., P. S. Pershan, G. Swislow, B. M. Ocko, and J. Als-Nielsen. 1988. Capillary waves on the surface of simple liquids measured by x-ray reflectivity. Phys. Rev. A. 38:2457-2470.
4. Cantor, R. S. 1997. The lateral pressure profile in membranes: a physical mechanism of general anesthesia. Biochemistry. 36:2339-2344.
5. Chiara, D. C., L. J. Dangott, R. G. Eckenhoff, and J. B. Cohen. 2003. Identification of nicotinic acetylcholine receptor amino acids photo-labeled by the volatile anesthetic halothane. Biochemistry. 42:13457-13467.
6. Choma, C., H. Gratkowski, J. D. Lear, and W. F. DeGrado. 2000. Asparagine-mediated self-association of a model transmembrane helix. Nat. Struct. Biol. 7:161-166.
7. Discher, B. M., R. L. Koder, C. C. Moser, and P. L. Dutton. 2003. Hydrophilic to amphiphilic design in redox protein maquettes. Curr. Opin. Struct. Biol. 7:741-748.
8. + conduction and selectivity. Science. 280:69-77.
9. Eckenhoff, R. G., and J. S. Johansson. 1997. Molecular interactions between inhaled anesthetics and proteins. Pharmacol. Rev. 49:343-367.
10. Franks, N. P., and W. R. Lieb. 1994. Molecular and cellular mechanisms of general-anesthesia. Nature. 367:607-614.
11. Franks, N. P., and W. R. Lieb. 1998. Which molecular targets are most relevant to general anaesthesia? Toxicol. Lett. 101:1-8.
12. Gratkowski, H., J. D. Lear, and W. F. DeGrado. 2001. Polar side chains drive the association of model transmembrane peptides. Proc. Natl. Acad. Sci. USA. 98:880-885.
13. Hauet, N., F. Artzner, F. Boucher, C. Grabielle-Madelmont, I. Cloutier, G. Keller, P. Lesieur, D. Durand, and M. Paternostre. 2003. Interaction between artificial membranes and enflurane, a general volatile anesthetic: DPPC-enflurane interaction. Biophys. J. 84:3123-3137.
14. Helm, C. A., P. Tippmannkrayer, H. Mohwald, J. Als-Nielsen, and K. Kjaer. 1991. Phases of phosphatidyl ethanolamine monolayers studied by synchrotron x-ray scattering. Biophys. J. 60:1457-1476.
15. + channel. Nature. 423:33-41.
16. Johansson, J. S. 2001. Synthetic β-helical bundles as tools for defining the structural features of volatile general anesthetic binding sites on protein targets. Recent Res. Dev. Biophys. Chem. 2:37-52.
17. Johansson, J. S. 2003. Noninactivating tandem pore domain potassium channels as attractive targets for general anesthetics. Anesth. Analg. 96:1248-1250.
18. Johansson, J. S., B. R. Gibney, F. Rabanal, K. S. Reddy, and P. L. Dutton. 1998. A designed cavity in the hydrophobic core of a four-a-helix bundle improves volatile anesthetic binding affinity. Biochemistry. 37:1421-1429.
19. Johansson, J. S., D. Scharf, L. A. Davies, K. S. Reddy, and R. G. Eckenhoff. 2000. A designed four-α-helix bundle that binds the volatile general anesthetic halothane with high affinity. Biophys. J. 78:982-993.
20. Johansson, J. S., and R. G. Eckenhoff. 1996. Minimum structural requirement for an inhalational anesthetic binding site on a protein target. Biochim. Biophys. Acta. 1290:63-68.
21. Johansson, J. S., R. G. Eckenhoff, and P. L. Dutton. 1995. Binding of halothane to serum albumin demonstrated by using tryptophan fluorescence. Anesthesiology. 83:316-324.
22. Johansson, J. S., F. Rabanal, and P. L. Dutton. 1996. Binding of the volatile anesthetic halothane to the hydrophobic core of a tetra-α-helix- bundle protein. J. Pharmacol. Exp. Ther. 279:56-61.
23. Krasowski, M. D., and N. L. Harrison. 1999. General anaesthetic actions on ligand-gated ion channels. Cell. Mol. Life Sci. 55:1278-1303.
24. Lear, J. D., Z. R. Wasserman, and W. F. Degrado. 1988. Synthetic amphiphilic peptide models for protein ion channels. Science. 240:1177-1181.
25. Lösche, M., M. Piepenstock, A. Diederich, T. Grunewald, K. Kjaer, and D. Vaknin. 1993. Influence of surface-chemistry on the structural organization of monomolecular protein layers adsorbed to functionalized aqueous interfaces. Biophys. J. 65:2160-2177.
26. Luo, P. Z., and R. L. Baldwin. 1997. Mechanism of helix induction by trifluoroethanol: a framework for extrapolating the helix-forming properties of peptides from trifluoroethanol/water mixtures back to water. Biochemistry. 36:8413-8421.
27. Manderson, G. A., and J. S. Johansson. 2002. Role of aromatic side chains in the binding of volatile general anesthetics to a four-α-helix bundle. Biochemistry. 41:4080-4087.
28. Marvin, J. S., E. E. Corcoran, N. A. Hattangadi, J. V. Zhang, S. A. Gere, and H. W. Hellinga. 1997. The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. Proc. Natl. Acad. Sci. USA. 94:4366-4371.
29. Noy, D., J. R. Calhoun, and J. D. Lear. 2003. Direct analysis of protein sedimentation equilibrium in detergent solutions without density matching. Anal. Biochem. 320:185-192.
30. Opella, S. J., F. M. Marassi, J. J. Gesell, A. P. Valente, Y. Kim, M. Oblatt-Montal, and M. Montal. 1999. Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat. Struct. Biol. 6:374-379.
31. Popot, J. L., and D. M. Engelman. 2000. Helical membrane protein folding, stability, and evolution. Annu. Rev. Biochem. 69:881-922.
32. Richards, F. M. 1974. The interpretation of protein structures: total volume, group volume distributions and packing density. J. Mol. Biol. 82:1-14.
33. Sixma, T. K., and A. B. Smit. 2003. Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels. Annu. Rev. Biophys. Biomembr. 32:311-334.
34. Skalicky, J. J., B. R. Gibney, F. Rabanal, R. J. B. Urbauer, P. L. Dutton, and A. J. Wand. 1999. Solution structure of a designed four-α-helix bundle maquette scaffold. J. Am. Chem. Soc. 121:4941-4951.
35. Spencer, R. H., and D. C. Rees. 2002. The α-helix and the organization and gating of channels. Annu. Rev. Biophys. Biomembr. 31:207-233.
36. Strzalka, J. W., X. Chen, C. C. Moser, P. L. Dutton, B. M. Ocko, and J. K. Blasie. 2000. X-ray scattering studies of maquette peptide monolayers. 1. Reflectivity and grazing incidence diffraction at the air/water interface. Langmuir. 16:10404-10418.
37. Strzalka, J., E. DiMasi, I. Kuzmenko, T. Gog, and J. K. Blasie. 2004a. Resonant x-ray reflectivity from a bromine-labeled fatty acid Langmuir monolayer. Phys. Rev. E. In press.
38. Strzalka, J., B. R. Gibney, S. Satija, and J. K. Blasie. 2004b. Specular neutron reflectivity and the structure of artificial protein maquettes vectorially oriented at interfaces. Phys. Rev. E. In press.
39. Tang, P., P. K. Mandal, and Y. Xu. 2002. NMR structures of the second transmembrane domain of the human glycine receptor α1 subunit: model of pore architecture and channel gating. Biophys. J. 83:252-262.
40. Tatulian, S. A., and L. K. Tamm. 2000. Secondary structure, orientation, oligomerization, and lipid interactions of the transmembrane domain of influenza hemagglutinin. Biochemistry. 39:496-507.
41. Ulmschneider, M. B., and M. S. P. Sansom. 2001. Amino acid distributions in integral membrane protein structures. BBA Biomembr. 1512:1-14.
42. Unwin, N. 1995. Acetylcholine-receptor channel imaged in the open state. Nature. 373:37-43.
43. Xu, Y., T. Seto, P. Tang, and L. Firestone. 2000. NMR study of volatile anesthetic binding to nicotinic acetylcholine receptors. Biophys. J. 78: 746-751.
44. Ye, S., J. W. Strzalka, B. M. Discher, D. Noy, S. Zheng, P. L. Dutton, and J. K. Blasie. 2004. Amphiphilic 4-helix bundles designed for biomolecular materials applications. Langmuir. 20:5897-5904.
45. Zheng, S., J. Strzalka, D. H. Jones, S. J. Opella, and J. K. Blasie. 2003. Comparative structural studies of VPU peptides in phospholipid monolayers by x-ray scattering. Biophys. J. 84:2393-2415.