Protein conformational transitions coupled to binding in molecular recognition of unstructured proteins: Hierarchy of Structural Loss from All-Atom Monte Carlo Simulations of p27Kip1 unfolding-unbinding and structural determinants of the binding mechanism

Biopolymers

Volumn 75, Issue 5, 2004, Pages 420-433

  Verkhivker, Gennady M ^a  

^a PFIZER INC   (United States)

Author keywords

Conformational transitions; Energy landscapes; Molecular recognition; Monte Carlo simulations; Protein folding

Indexed keywords

BINDING ENERGY; COMPLEXATION; CONFORMATIONS; CRYSTAL STRUCTURE; ENTROPY; MONTE CARLO METHODS; PHOSPHORS; REACTION KINETICS; SUBSTRATES;

BINARY COMPLEX; BINDING REACTION; INTERMOLECULAR INTERFACE; PROTEIN CONFORMATIONAL TRANSITIONS;

PROTEINS;

PROTEIN P27;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENTROPY; MOLECULAR RECOGNITION; MONTE CARLO METHOD; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMULATION;

CELL CYCLE PROTEINS; COMPUTATIONAL BIOLOGY; CYCLIN-DEPENDENT KINASE INHIBITOR P27; MONTE CARLO METHOD; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; TUMOR SUPPRESSOR PROTEINS;

EID: 10044241910     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.20149     Document Type: Article

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