-
1
-
-
0025169561
-
An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection
-
Ashorn, P., T. J. McQuade, S. Thaisrivongs, A. G. Tomasselli, W. G. Tarpley, and B. Moss. 1990. An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection. Proc. Natl. Acad. Sci. USA 87:7472-7476.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7472-7476
-
-
Ashorn, P.1
McQuade, T.J.2
Thaisrivongs, S.3
Tomasselli, A.G.4
Tarpley, W.G.5
Moss, B.6
-
2
-
-
0034284897
-
Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: Clinical significance and implications for resistance to protease inhibitors
-
Bally, F., R. Martinez, S. Peters, P. Sudre, and A. Telenti. 2000. Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors. AIDS Res. Hum. Retrovir. 16:1209-1213.
-
(2000)
AIDS Res. Hum. Retrovir.
, vol.16
, pp. 1209-1213
-
-
Bally, F.1
Martinez, R.2
Peters, S.3
Sudre, P.4
Telenti, A.5
-
3
-
-
0031724008
-
Resistance to human immunodeficiency virus type 1 protease inhibitors
-
Boden, D., and M. Markowitz. 1998. Resistance to human immunodeficiency virus type 1 protease inhibitors. Antimicrob. Agents Chemother. 42:2775-2783.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 2775-2783
-
-
Boden, D.1
Markowitz, M.2
-
4
-
-
0030065565
-
Resistance of human immunodeficiency virus type 1 to protease inhibitors: Selection of resistance mutations in the presence and absence of the drug
-
Borman, A. M., S. Paulons, and F. Clavel. 1996. Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug. J. Gen. Virol. 77:419-426.
-
(1996)
J. Gen. Virol.
, vol.77
, pp. 419-426
-
-
Borman, A.M.1
Paulons, S.2
Clavel, F.3
-
5
-
-
0031849665
-
In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor
-
Carrillo, A., K. D. Stewart, H. L. Sham, D. W. Norbeck, W. E. Kohlhrenner, J. M. Leonard, D. J. Kempf, and A. Molla. 1998. In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J. Virol. 72:7532-7541.
-
(1998)
J. Virol.
, vol.72
, pp. 7532-7541
-
-
Carrillo, A.1
Stewart, K.D.2
Sham, H.L.3
Norbeck, D.W.4
Kohlhrenner, W.E.5
Leonard, J.M.6
Kempf, D.J.7
Molla, A.8
-
6
-
-
10344263394
-
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor
-
Condra, J. H., D. J. Holder, W. A. Schleif, O. M. Blahy, R. M. Danovich, L. J. Garhyelski, D. J. Graham, D. Laird, J. C. Quintero, A. Rhodes, H. L. Robbins, E. Roth, M. Shivaprakash, T. Yang, J. A. Chodakewitz, P. J. Deutsch, R. Y. Leavitt, F. E. Massari, J. W. Mellors, K. E. Squires, R. T. Steigbigel, H. Teppler, and E. A. Emini. 1996. Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J. Virol. 70:8270-8276.
-
(1996)
J. Virol.
, vol.70
, pp. 8270-8276
-
-
Condra, J.H.1
Holder, D.J.2
Schleif, W.A.3
Blahy, O.M.4
Danovich, R.M.5
Garhyelski, L.J.6
Graham, D.J.7
Laird, D.8
Quintero, J.C.9
Rhodes, A.10
Robbins, H.L.11
Roth, E.12
Shivaprakash, M.13
Yang, T.14
Chodakewitz, J.A.15
Deutsch, P.J.16
Leavitt, R.Y.17
Massari, F.E.18
Mellors, J.W.19
Squires, K.E.20
Steigbigel, R.T.21
Teppler, H.22
Emini, E.A.23
more..
-
7
-
-
0028943992
-
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
Condra, J. H., W. A. Schleif, O. M. Blahy, L. J. Gahryelski, D. J. Graham, J. C. Quintero, A. Rhodes, H. L. Robbins, E. Roth, M. Shivaprakash, D. Titus, T. Yang, H. Teppler, K. E. Squires, P. J. Deutsch, and E. A. Emini. 1995. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 374:569-571.
-
(1995)
Nature
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
Gahryelski, L.J.4
Graham, D.J.5
Quintero, J.C.6
Rhodes, A.7
Robbins, H.L.8
Roth, E.9
Shivaprakash, M.10
Titus, D.11
Yang, T.12
Teppler, H.13
Squires, K.E.14
Deutsch, P.J.15
Emini, E.A.16
-
8
-
-
0035163687
-
Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir
-
Cote, H. C., Z. L. Brumme, and P. R. Harrigan. 2001. Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir. J. Virol. 75:589-594.
-
(2001)
J. Virol.
, vol.75
, pp. 589-594
-
-
Cote, H.C.1
Brumme, Z.L.2
Harrigan, P.R.3
-
9
-
-
0031015475
-
Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors
-
Croteau, G., L. Doyon, D. Thiheault, G. McKercher, L. Pilote, and D. Lamarre. 1997. Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J. Virol. 71:1089-1096.
-
(1997)
J. Virol.
, vol.71
, pp. 1089-1096
-
-
Croteau, G.1
Doyon, L.2
Thiheault, D.3
McKercher, G.4
Pilote, L.5
Lamarre, D.6
-
10
-
-
0036147360
-
Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease
-
Dauher, D. S., R. Ziermann, N. Parkin, D. J. Maly, S. Mahrus, J. L. Harris, J. A. Ellman, C. Petropoulos, and C. S. Craik. 2002. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. J. Virol. 76:1359-1368.
-
(2002)
J. Virol.
, vol.76
, pp. 1359-1368
-
-
Dauher, D.S.1
Ziermann, R.2
Parkin, N.3
Maly, D.J.4
Mahrus, S.5
Harris, J.L.6
Ellman, J.A.7
Petropoulos, C.8
Craik, C.S.9
-
11
-
-
0026579208
-
The HIV-1 protease as a therapeutic target for AIDS
-
Dehouck, C. 1992. The HIV-1 protease as a therapeutic target for AIDS. AIDS Res. Hum. Retrovir. 8:153-164.
-
(1992)
AIDS Res. Hum. Retrovir.
, vol.8
, pp. 153-164
-
-
Dehouck, C.1
-
12
-
-
0035864943
-
Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
-
Deeks, S. G., T. Wrin, T. Liegler, R. Hoh, M. Hayden, J. D. Barbour, N. S. Hellmann, C. J. Petropoulos, J. M. McCune, M. K. Hellerstein, and R. M. Grant. 2001. Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N. Engl. J. Med. 344:472-480.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 472-480
-
-
Deeks, S.G.1
Wrin, T.2
Liegler, T.3
Hoh, R.4
Hayden, M.5
Barbour, J.D.6
Hellmann, N.S.7
Petropoulos, C.J.8
McCune, J.M.9
Hellerstein, M.K.10
Grant, R.M.11
-
13
-
-
0344334073
-
Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity
-
de la Carriere, L. C., S. Paulous, F. Clavel, and F. Mammano. 1999. Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity. J. Virol. 73:3455-3459.
-
(1999)
J. Virol.
, vol.73
, pp. 3455-3459
-
-
De La Carriere, L.C.1
Paulous, S.2
Clavel, F.3
Mammano, F.4
-
14
-
-
0029899093
-
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
-
Doyon, L., G. Croteau, D. Thibeault, F. Poulin, L. Pilote, and D. Lamarre. 1996. Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors. J. Virol. 70:3763-3769.
-
(1996)
J. Virol.
, vol.70
, pp. 3763-3769
-
-
Doyon, L.1
Croteau, G.2
Thibeault, D.3
Poulin, F.4
Pilote, L.5
Lamarre, D.6
-
15
-
-
0035168058
-
Immunogenicity and protective efficacy of oligomeric human immunodeficiency virus type 1 gp140
-
Earl, P. L., W. Sugiura, D. C. Montefiori, C. C. Broder, S. A. Lee, C. Wild, J. Lifson, and B. Moss. 2001. Immunogenicity and protective efficacy of oligomeric human immunodeficiency virus type 1 gp140. J. Virol. 75:645-653.
-
(2001)
J. Virol.
, vol.75
, pp. 645-653
-
-
Earl, P.L.1
Sugiura, W.2
Montefiori, D.C.3
Broder, C.C.4
Lee, S.A.5
Wild, C.6
Lifson, J.7
Moss, B.8
-
16
-
-
0029157399
-
The not-so-great escape
-
Erickson, J. W. 1995. The not-so-great escape. Nat. Struct. Biol. 2:523-529.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 523-529
-
-
Erickson, J.W.1
-
17
-
-
0036039725
-
Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites
-
Feher, A., I. T. Weher, P. Ragossi, P. Boross, B. Mahalingam, J. M. Louis, T. D. Copeland, I. Y. Torshin, R. W. Harrison, and J. Tozser. 2002. Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites. Eur. J. Biochem. 269:4114-4120.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 4114-4120
-
-
Feher, A.1
Weher, I.T.2
Ragossi, P.3
Boross, P.4
Mahalingam, B.5
Louis, J.M.6
Copeland, T.D.7
Torshin, I.Y.8
Harrison, R.W.9
Tozser, J.10
-
18
-
-
0037155193
-
Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors
-
Gatanaga, H., Y. Suzuki, H. Tsang, K. Yoshimura, M. F. Kavlick, K. Nagashima, R. J. Gorelick, S. Mardy, C. Tang, M. F. Summers, and H. Mitsuya. 2002. Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J. Biol. Chem. 277:5952-5961.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5952-5961
-
-
Gatanaga, H.1
Suzuki, Y.2
Tsang, H.3
Yoshimura, K.4
Kavlick, M.F.5
Nagashima, K.6
Gorelick, R.J.7
Mardy, S.8
Tang, C.9
Summers, M.F.10
Mitsuya, H.11
-
19
-
-
0023099283
-
Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins
-
Gelderblom, H. R., E. H. Hausmann, M. Ozel, G. Pauli, and M. A. Koch. 1987. Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virology 156:171-176.
-
(1987)
Virology
, vol.156
, pp. 171-176
-
-
Gelderblom, H.R.1
Hausmann, E.H.2
Ozel, M.3
Pauli, G.4
Koch, M.A.5
-
20
-
-
0025283822
-
Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA
-
Gorelick, R. J., S. M. Nigida, Jr., J. W. Bess, Jr., L. O. Arthur, L. E. Henderson, and A. Rein. 1990. Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol. 64:3207-3211.
-
(1990)
J. Virol.
, vol.64
, pp. 3207-3211
-
-
Gorelick, R.J.1
Nigida Jr., S.M.2
Bess Jr., J.W.3
Arthur, L.O.4
Henderson, L.E.5
Rein, A.6
-
21
-
-
0030869269
-
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
-
Gulick R. M., J. W. Mellors, D. Havlir, J. J. Eron, C. Gonzalez, D. McMahon, D. D. Richman, F. T. Valentine, L. Jonas, A. Meihohm, E. A. Emini, and J. A. Chodakewitz. 1997. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N. Engl. J. Med. 337:734-739.
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 734-739
-
-
Gulick, R.M.1
Mellors, J.W.2
Havlir, D.3
Eron, J.J.4
Gonzalez, C.5
McMahon, D.6
Richman, D.D.7
Valentine, F.T.8
Jonas, L.9
Meihohm, A.10
Emini, E.A.11
Chodakewitz, J.A.12
-
22
-
-
0028286025
-
Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease
-
Kaplan, A. H., S. F. Michael, R. S. Wehbie, M. F. Knigge, D. A. Paul, L. Everitt, D. J. Kempf, D. W. Norbeck, J. W. Erickson, and R. Swanstrom, 1994. Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc. Natl. Acad. Sci. USA 91:5597-5601.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5597-5601
-
-
Kaplan, A.H.1
Michael, S.F.2
Wehbie, R.S.3
Knigge, M.F.4
Paul, D.A.5
Everitt, L.6
Kempf, D.J.7
Norbeck, D.W.8
Erickson, J.W.9
Swanstrom, R.10
-
23
-
-
0027158754
-
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles
-
Kaplan, A. H., J. A. Zack, M. Knigge, D. A. Paul, D. J. Kempf, D. W. Norbeck, and R. Swanstrom. 1993. Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles. J. Virol. 67:4050-4055.
-
(1993)
J. Virol.
, vol.67
, pp. 4050-4055
-
-
Kaplan, A.H.1
Zack, J.A.2
Knigge, M.3
Paul, D.A.4
Kempf, D.J.5
Norbeck, D.W.6
Swanstrom, R.7
-
24
-
-
0034915565
-
Impact of HIV type 1 protease, reverse transcriptase, cleavage site, and p6 mutations on the virological response to quadruple therapy with saquinavir, ritonavir, and two nucleoside analogs
-
Kaufmann, G. R., K. Suzuki, P. Cunningham, M. Mukaide, M. Kondo, M. Imai, J. Zaunders, and D. A. Cooper. 2001. Impact of HIV type 1 protease, reverse transcriptase, cleavage site, and p6 mutations on the virological response to quadruple therapy with saquinavir, ritonavir, and two nucleoside analogs. AIDS Res. Hum. Retrovir. 17:487-497.
-
(2001)
AIDS Res. Hum. Retrovir.
, vol.17
, pp. 487-497
-
-
Kaufmann, G.R.1
Suzuki, K.2
Cunningham, P.3
Mukaide, M.4
Kondo, M.5
Imai, M.6
Zaunders, J.7
Cooper, D.A.8
-
25
-
-
0035831126
-
Mutations in HIV-1 gag cleavage sites and their association with protease mutations
-
Koch, N., N. Yahi, J. Fantini, and C. Tamalet. 2001. Mutations in HIV-1 gag cleavage sites and their association with protease mutations. AIDS 15:526-528.
-
(2001)
AIDS
, vol.15
, pp. 526-528
-
-
Koch, N.1
Yahi, N.2
Fantini, J.3
Tamalet, C.4
-
26
-
-
0005241362
-
Active human immunodeficiency virus protease is required for viral infectivity
-
Kohl, N. E., E. A. Emini, W. A. Schleif, L. J. Davis, J. C. Heimbach, R. A. Dixon, E. M. Scolnick, and I. S. Sigal. 1988. Active human immunodeficiency virus protease is required for viral infectivity. Proc. Natl. Acad. USA 85:4686-4690.
-
(1988)
Proc. Natl. Acad. USA
, vol.85
, pp. 4686-4690
-
-
Kohl, N.E.1
Emini, E.A.2
Schleif, W.A.3
Davis, L.J.4
Heimbach, J.C.5
Dixon, R.A.6
Scolnick, E.M.7
Sigal, I.S.8
-
27
-
-
0029013585
-
The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity
-
Krausslieh, H. G., M. Facke, A. M. Heuser, J. Konvalinka, and H. Zentgraf. 1995. The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity. J. Virol. 69:3407-3419.
-
(1995)
J. Virol.
, vol.69
, pp. 3407-3419
-
-
Krausslieh, H.G.1
Facke, M.2
Heuser, A.M.3
Konvalinka, J.4
Zentgraf, H.5
-
28
-
-
0036310578
-
Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to 150V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro
-
Maguire, M. F., R. Guinea, P. Griffin, S. Macmanus, R. C. Elston, J. Wolfram, N. Richards, M. H. Hanlon, D. J. Porter, T. Wrin, N. Parkin, M. Tisdale, E. Furfine, C. Petropoulos, B. W. Snowden, and J. P. Kleim. 2002. Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to 150V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro. J. Virol. 76:7398-7406.
-
(2002)
J. Virol.
, vol.76
, pp. 7398-7406
-
-
Maguire, M.F.1
Guinea, R.2
Griffin, P.3
Macmanus, S.4
Elston, R.C.5
Wolfram, J.6
Richards, N.7
Hanlon, M.H.8
Porter, D.J.9
Wrin, T.10
Parkin, N.11
Tisdale, M.12
Furfine, E.13
Petropoulos, C.14
Snowden, B.W.15
Kleim, J.P.16
-
29
-
-
0031846317
-
Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
-
Mammano, F., C. Petit, and F. Clavel. 1998. Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients. J. Virol. 72:7632-7637.
-
(1998)
J. Virol.
, vol.72
, pp. 7632-7637
-
-
Mammano, F.1
Petit, C.2
Clavel, F.3
-
30
-
-
0023755462
-
The gag gene products of human immunodeficiency virus type 1: Alignment within the gag open reading frame, identification of posttranslational modifications, and evidence for alternative gag precursors
-
Mervis, R. J., N. Ahmad, E. P. Lillehoj, M. G. Raum, F. H. Salazar, H. W. Chan, and S. Venkatesan. 1988. The gag gene products of human immunodeficiency virus type 1: alignment within the gag open reading frame, identification of posttranslational modifications, and evidence for alternative gag precursors. J. Virol. 62:3993-4002.
-
(1988)
J. Virol.
, vol.62
, pp. 3993-4002
-
-
Mervis, R.J.1
Ahmad, N.2
Lillehoj, E.P.3
Raum, M.G.4
Salazar, F.H.5
Chan, H.W.6
Venkatesan, S.7
-
32
-
-
15444377672
-
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
-
Molla, A., M. Korneyeva, Q. Gao, S. Vasavanonda, P. J. Schipper, H. M. Mo, M. Markowitz, T. Chernyavskiy, P. Niu, N. Lyons, A. Hsu, G. R. Granneman, D. D. Ho, C. A. Boucher, J. M. Leonard, D. W. Norheck, and D. J. Kempf. 1996. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat. Med. 2:760-766.
-
(1996)
Nat. Med.
, vol.2
, pp. 760-766
-
-
Molla, A.1
Korneyeva, M.2
Gao, Q.3
Vasavanonda, S.4
Schipper, P.J.5
Mo, H.M.6
Markowitz, M.7
Chernyavskiy, T.8
Niu, P.9
Lyons, N.10
Hsu, A.11
Granneman, G.R.12
Ho, D.D.13
Boucher, C.A.14
Leonard, J.M.15
Norheck, D.W.16
Kempf, D.J.17
-
33
-
-
0024334170
-
Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity
-
Peng, C., B. K. Ho, T. W. Chang, and N. T. Chang. 1989. Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity. J. Virol. 63:2550-2556.
-
(1989)
J. Virol.
, vol.63
, pp. 2550-2556
-
-
Peng, C.1
Ho, B.K.2
Chang, T.W.3
Chang, N.T.4
-
34
-
-
0036784575
-
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
-
Pettit, S. C., G. J. Henderson, C. A. Schiffer, and R. Swanstrom. 2002. Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease. J. Virol. 76:10226-10233.
-
(2002)
J. Virol.
, vol.76
, pp. 10226-10233
-
-
Pettit, S.C.1
Henderson, G.J.2
Schiffer, C.A.3
Swanstrom, R.4
-
35
-
-
0036121219
-
Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
-
Prahu-Jeyahalan, M., E. Nalivaika, and C. A. Schiffer. 2002. Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. Structure (Cambridge) 10:369-381.
-
(2002)
Structure (Cambridge)
, vol.10
, pp. 369-381
-
-
Prahu-Jeyahalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
36
-
-
0037012979
-
Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity
-
Prado, J.G., T. Wrin, J. Beauchaine, L. Ruiz, C. J. Petropoulos, S. D. Frost, B. Clotet, R. T. D'Aquila, and J. Martinez-Picado. 2002. Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity. AIDS 16:1009-1017.
-
(2002)
AIDS
, vol.16
, pp. 1009-1017
-
-
Prado, J.G.1
Wrin, T.2
Beauchaine, J.3
Ruiz, L.4
Petropoulos, C.J.5
Frost, S.D.6
Clotet, B.7
D'Aquila, R.T.8
Martinez-Picado, J.9
-
37
-
-
0035912249
-
HIV chemotherapy
-
Richman, D. 2001. HIV chemotherapy. Nature 410:995-1001.
-
(2001)
Nature
, vol.410
, pp. 995-1001
-
-
Richman, D.1
-
38
-
-
0029869305
-
Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors
-
Rose, R. E., Y. F. Gong, J. A. Greytok, C. M. Bechtold, B. J. Terry, B. S. Robinson, M. Alam, R. J. Colonno, and P. F. Lin. 1996. Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proc. Natl. Acad. Sci. USA 93:1648-1653.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1648-1653
-
-
Rose, R.E.1
Gong, Y.F.2
Greytok, J.A.3
Bechtold, C.M.4
Terry, B.J.5
Robinson, B.S.6
Alam, M.7
Colonno, R.J.8
Lin, P.F.9
-
39
-
-
0034856077
-
Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation
-
Shehu-Xhilaga, M., H. G. Kraeusslich, S. Pettit, R. Swanstrom, J. Y. Lee, J. A. Marshall, S. M. Crowe, and J. Mak. 2001. Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation. J. Virol. 75:9156-9164.
-
(2001)
J. Virol.
, vol.75
, pp. 9156-9164
-
-
Shehu-Xhilaga, M.1
Kraeusslich, H.G.2
Pettit, S.3
Swanstrom, R.4
Lee, J.Y.5
Marshall, J.A.6
Crowe, S.M.7
Mak, J.8
-
40
-
-
0030738085
-
Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease
-
Sheng, N., S. C. Pettit, R. J. Tritch, D. H. Ozturk, M. M. Rayner, R. Swanstrom, and S. Erickson-Viitanen. 1997. Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease. J. Virol. 71:5723-5732.
-
(1997)
J. Virol.
, vol.71
, pp. 5723-5732
-
-
Sheng, N.1
Pettit, S.C.2
Tritch, R.J.3
Ozturk, D.H.4
Rayner, M.M.5
Swanstrom, R.6
Erickson-Viitanen, S.7
-
41
-
-
0036168452
-
Interference between D30N and L90M in selection and development of protease inhibitor-resistant human immunodeficiency virus type 1
-
Sugiura, W., Z. Matsuda, Y. Yokomaku, K. Hertogs, B. Larder, T. Oishi, A. Okano, T. Shiino, M. Tatsumi, M. Matsuda, H. Abumi, N. Takata, S. Shirabata, K. Yamada, H. Yoshikura, and Y. Nagai. 2002. Interference between D30N and L90M in selection and development of protease inhibitor-resistant human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 46:708-715.
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 708-715
-
-
Sugiura, W.1
Matsuda, Z.2
Yokomaku, Y.3
Hertogs, K.4
Larder, B.5
Oishi, T.6
Okano, A.7
Shiino, T.8
Tatsumi, M.9
Matsuda, M.10
Abumi, H.11
Takata, N.12
Shirabata, S.13
Yamada, K.14
Yoshikura, H.15
Nagai, Y.16
-
42
-
-
2642680072
-
Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity
-
Tessmer, U., and H. G. Krausslich. 1998. Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity. J. Virol. 72:3459-3463.
-
(1998)
J. Virol.
, vol.72
, pp. 3459-3463
-
-
Tessmer, U.1
Krausslich, H.G.2
-
43
-
-
0031946007
-
Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo
-
Zennou, V., F. Mammano, S. Paulous, D. Mathez, and F. Clavel. 1998. Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo. J. Virol. 72:3300-3306.
-
(1998)
J. Virol.
, vol.72
, pp. 3300-3306
-
-
Zennou, V.1
Mammano, F.2
Paulous, S.3
Mathez, D.4
Clavel, F.5
-
44
-
-
0030769354
-
Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
-
Zhang, Y. M., H. Imamichi, T. Imamichi, H. C. Lane, J. Falloon, M. B. Vasudevachari, and N. P. Salzman. 1997. Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites. J. Virol. 71:6662-6670.
-
(1997)
J. Virol.
, vol.71
, pp. 6662-6670
-
-
Zhang, Y.M.1
Imamichi, H.2
Imamichi, T.3
Lane, H.C.4
Falloon, J.5
Vasudevachari, M.B.6
Salzman, N.P.7
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