Regulated heat shock protein 27 expression in human retinal pigment epithelium

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 9, 2001, Pages 2130-2138

  Strunnikova, N ^a   Baffi, J ^a   Gonzalez, A ^a   Silk, W ^a   Cousins, S W ^a   Csaky, K G ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 27;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION FUNCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NORTHERN BLOTTING; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RETINA MACULA AGE RELATED DEGENERATION; RETINA PIGMENT DEGENERATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL DIVISION; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LUMINESCENT PROTEINS; PHOTORECEPTORS, VERTEBRATE; PIGMENT EPITHELIUM OF EYE; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED LEW; RETINAL GANGLION CELLS; RETROVIRIDAE; RNA, MESSENGER; TRANSFECTION;

EID: 0034908893     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Comet assay of UV-induced DNA damage in retinal pigment epithelial cells
2. Regulation of the local immune response by retinal cells
3. Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells
4. Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells
5. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors
6. The five-year incidence and progression of age-related maculopathy: The Beaver Dam Eye Study
7. Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration
8. The heat-shock response
9. Constitutive and inducible heat shock protein 70 immunoreactivity in the normal rat eye
10. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes
11. Induction of stress proteins in cultured human RPE-derived cells
12. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27
13. Small stress proteins as novel regulators of apoptosis: Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death
14. Accelerated growth and senescence of arterial endothelial cells expressing the small molecular weight heat-shock protein HSP27
15. Hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells
16. Tumor necrosis factor-alpha induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine
17. Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death
18. Small heat shock proteins and protection against ischemic injury in cardiac myocytes
19. Influence of phosphorylation and oligomerization on the protective role of the small heat shock protein 27 in rat adult cardiomyocytes
20. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity
21. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
22. Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation
23. Small heat shock proteins are molecular chaperones
24. Adenovirus-mediated gene transfer of ornithine aminotransferase in cultured human retinal pigment epithelium
25. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
26. Retroviral mediated gene transfer of ornithine-delta-aminotransferase into keratinocytes from gyrate atrophy patients
27. A safe packaging line for gene transfer: Separating viral genes on two different plasmids
28. Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells
29. Development and analysis of retroviral vectors expressing human factor VIII as a potential gene therapy for hemophilia A
30. Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis
31. Early and delayed tolerance to simulated ischemia in heat-preconditioned endothelial cells: A role for HSP27
32. Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27)
33. Immortalization of polarized rat retinal pigment epithelium
34. A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins
35. Transient accumulation, phosphorylation and changes in the oligomerization of Hsp27 during retinoic acid-induced differentiation of HL-60 cells: Possible role in the control of cellular growth and differentiation
36. Chaperones in cell cycle regulation and mitogenic signal transduction: A review
37. Different constitutive heat shock protein 70 expression during proliferation and differentiation of rat C6 glioma cells
38. Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization
39. Use of the ARPE-19 cell line as a model of RPE polarity: Basolateral secretion of FGF5
40. Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells
41. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death
42. Oxidative damage and age-related macular degeneration
43. HSP27 inhibits cytochrome c-dependent activation of procaspase-9
44. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
45. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock HSP27 stabilization of the microfilament organization
46. Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells
47. Constitutive expression of the 27-kDa heat-shock protein in neurons and satellite cells in the peripheral nervous system of the rat
48. Macrophages related to Bruch's membrane in age-related macular degeneration
49. The oxidation of lipoproteins by monocytes-macrophages: Biochemical and biological mechanisms
50. Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro
51. New mechanism for glomerular injury: Myeloperoxidase-hydrogen peroxide-halide system
52. Myeloperoxidase is involved in H202-induced apoptosis of HL-60 human leukemia cells
53. Prostaglandins stimulate the stress-induced synthesis of hsp27 and alpha B crystallin
54. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
55. Cytoskeletal and morphologic impact of cellular oxidant injury
56. Both UVA and UVB induce cytoskeleton-dependent surface blebbing in epidermoid cells
57. Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: Alterations underlying surface bleb formation
58. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
59. Tyrosine phosphorylation of cortactin is required for H202-mediated injury of human endothelial cells
60. Regulation of plasma membrane blebbing by the cytoskeleton
61. All ras proteins are polyisoprenylated but only some are palmitoylated
62. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
63. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes
64. Long-term, stable expression of green fluorescent protein in mammalian cells
65. An in vivo rat model for visualizing glioma tumor cell invasion using stable persistent expression of the green fluorescent protein
66. Renal transplantation in patients with dense deposit disease: Morphological characteristics of recurrent disease and clinical outcome
67. Immunohistological and ultrastructural differences between recurrent type I membranoproliferative glomerulonephritis and chronic transplant glomerulopathy
68. Histopathology of age-related macular degeneration
69. Pathogenesis of drusen in the primate
70. Experimental changes resembling the pathology of drusen in Bruch's membrane in the rabbit
71. Identification of glycosaminoglycans in age-related macular deposits
72. Analysis of carbohydrate structures in basal laminar deposit in aging human maculae
73. Morphologic changes in age-related maculopathy
74. Basal linear deposit and large drusen are specific for early age-related maculopathy
75. Glycosaminoglycan synthesis and secretion by the retinal pigment epithelium: Polarized delivery of hyaluronan from the apical surface