Loss of heterozygosity in primary lung cancer using laser capture microdissection and WAVE DNA fragment analysis techniques

Medical Science Monitor

Volumn 8, Issue 3, 2002, Pages

  Zhu, Weigang ^a   Zou, Helen ^a   Beck, Amy ^a   Chervinsky, Dave ^a   Malik, Debbie ^a   Brooks, John J ^a   Tan, Dongfeng ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Laser capture; WAVE DNA Fragment Analysis

Indexed keywords

DNA FRAGMENT; DNA MARKER; FORMALDEHYDE; PARAFFIN;

ALLELE; ANALYTIC METHOD; ARTICLE; CHROMOSOME 3; CHROMOSOME MICRODISSECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; GEL ELECTROPHORESIS; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LYMPHOCYTE; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CHROMOSOMES, HUMAN, PAIR 3; DNA FRAGMENTATION; FEMALE; HUMANS; LASERS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC;

EID: 19244376104     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Clonal evolution of lung cancer
2. Allele specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma
3. Evidencve of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus
4. Detection of single nucleotide polymorphisms with the WAVE DNA fragment analysis system
5. Development ofsquamous cell lung carcinoma
6. Allelic specific loss of chromosome 9p loci in preneoplastic lesions accompanying non-small cell lung cancers
7. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumors, are detectable in preinvasive lesions of the bronchus
8. Multiple clonal abnormalities in the bronchial epithelium of patient with lung cancer
9. p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patient with non small cell lung carcinoma
10. Frequent loss of short arm of chromosome 9 in resected lung cancers from Japanese patients and its association with squamous cell carcinoma
11. Prognostic significant of p53 mutations and 3p deletions in primary resected non-small cell lung cancer
12. Homozygous deletion on chromosome 9p and loss of heterozygosity on 9p, 6p, and q in primary human small cell lung cancer
13. Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung
14. Allelotype of non-small cell lung carcinoma: Comparison of LOH between squamous cell carcinoma and adenocarcinoma
15. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinous sites of p allele loss and three regions of frequent breakpoints
16. The candidate tumor suppressor gene, RASSDIA, from human chromosome 3p21. 3 Is involved in kidney tumorigenesis
17. Loss of heterozygosity at the short arm of chromosome 3 in microdissected cervical intraepithelial neplasia
18. Loss of heterozygosity at 3p24-p25 as a prognostic facor in breast cancer
19. Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma
20. Detection of loss of heterozygosity at chromosome 3p5-26 in primary and metastaic ovarian clear-cell carcinoma: Utilization of microdissection and polymerase chain reaction in archival tissue