Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: Analysis of protein expression in Graves' thyroid tissue

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 11, 1997, Pages 3752-3757

  Gardas, A ^a   Lewartowska, A ^a   Sutton, B J ^c   Pasieka, Z ^b   Mcgregor, A M ^c   Banga, J P ^c  

^a MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^b INSTITUTE OF ENDOCRINOLOGY   (Poland)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; ISOENZYME; MESSENGER RNA; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RABBIT ANTISERUM; SYNTHETIC PEPTIDE; THYROID PEROXIDASE;

ARTICLE; GRAVES DISEASE; HUMAN; HUMAN TISSUE; MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ORYCTOLAGUS CUNICULUS;

EID: 0030684076     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.11.3752     Document Type: Article

References (33)

1. Nunez J, Pommier J. 1982 Formation of thyroid hormones. Vitam Horm. 39:175-229.
2. Banga JP, Barnett PS, McGregor AM. 1991 Immunological and molecular characteristics of the thyroid peroxidase autoantigen. Autoimmunity. 8:335-343.
3. Kimura S, Kotani T, McBride OW, et al. 1987 Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping and identification of two alternatively spliced mRNAs. Proc Natl Acad Sci. 84:5555-5559.
4. Magnusson RP, Chazenbalk GD, Gestautas J, et al. 1987 Molecular cloning of the complementary deoxyribonucleic acid for human thyroid peroxidase. Mol Endocrinol. 1:856-861.
5. Libert F, Ruel J, Ludgate M, et al. 1987 Thyroperoxidase an autoantigen with mosaic structure made of nuclear and mitochondrial gen modules. EMBO J. 6:4192-4196.
6. Kimura S, Hong YS, Kotani T, Ohtaki S, Kikkawa F. 1989 Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene. Biochemistry. 28:4481-4489.
7. Barnett PS, Banga JP, Watkins J, et al. 1990 Nucleotide sequence of the alternatively spliced human thyroid peroxidase cDNA, TPO-2. Nucleic Acids Res. 18:670.
8. Elisei R, Vassart G, Ludgate M. 1991 Demonstration of the existence of the alternatively spliced form of thyroid peroxidase in normal thyroid. J Clin Endocrinol Metab. 72:700-702.
9. Nagayama Y, Seto P, Rapoport B. 1990 Characterisation, by molecular cloning, of smaller forms of thyroid peroxidase messenger ribonucleic acid in human thyroid cells as alternatively spliced transcripts. J Clin Endocrinol Metab. 71:384-390.
10. Zanelli E, Hemry M, Charvet B, Malthiery Y. 1990 Evidence for an alternate splicing in the thyroid peroxidase messenger from patients with Graves' disease. Biochem Biophys Res Commun. 170:735-741.
11. Banga JP, Pryce G, Hammond L, Roitt IM. 1985 Structural features of the autoantigens involved in thyroid autoimmune disease: the thyroid microsomal/microvillar antigen. Mol Immunol. 22:629-642.
12. Czarnocka B, Ruf J, Ferrand M, Carayon PM, Lissitzky S. 1985 Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in the autoimmune thyroid disease. FEBS Lett. 190:142-152.
13. Hamada N, Grimm C, Mori H, DeGroot LJ. 1985 Identification of a thyroid microsomal antigen by Western blot and immunoprecipitation. J Clin Endocrinol Metab. 61:120-128.
14. Foti D, Kaufman KD, Chazenbalk G, Rapoport B. 1990 Generation of a biologically active, secreted form of human thyroid peroxidase by site directed mutagenesis. Mol Endocrinol. 4:786-791.
15. Kaufman KD, Rapoport B, Seto P, Chazenbalk GD, Magnusson RP. 1989 Generation of recombinant, enzymatically active, human thyroid peroxidase and its recognition by antibodies in the sera of patients with Hashimoto's thyroditis. J Clin Invest. 84:394-403.
16. Barnett PS. 1993 Cloning and expression of recombinant thyroid peroxidase for immunological investigations in autoimmune thyroid disease. PhD thesis, University of London.
17. Kendler DL, Brennan V, Davies T, Magnusson RP. 1993 Expression of human thyroid peroxidase in insect cells using recombinant baculovirus. Mol Cell Endocrinol. 93:199-206.
18. Seto PY, Nagayama Y, Foti D, McLachlan SM, Rapoport B. 1993 Autoantibodies in the sera of patients with autoimmune thyroid disease recognise a secreted form of human thyroid peroxidase generated in a baculovirus system. Mol Cell Endocrinol 94:R5-R8.
19. Haubruck H, Mauch L, Cook NJ, et al. 1993 Expression of recombinant thyroid peroxidase by the baculovirus system and its use in ELISA screening for diagnosis of autoimmune thyroid disease. Autoimmunity. 15:275-284.
20. Fan JL, Patibandia SA, Kimura S, et al. 1996 Purification and characterisation of a recombinant human thyroid peroxidase expressed in insect cells. J Autoimmun. 9:529-536.
21. Grennan Jones F, Wolstenholme A, Fowler S, Smith S, Ziemnica K, Bradbury J, Furmaniak J, Rees Smith B. 1996 High level expression of recombinant immunoreactive thyroid peroxidase in the High Five insect cell line. J Mol Endocrinol. 17:165-174.
22. Kimura S, Ikeso-Saito M. 1988 Human meyeloperoxidase and thyroid peroxidase, two enzymes with separate functions, are evolutionary related members of the same gene family. Protein Structure, Function and Genetics. 3:113-120.
23. Banga JP, Mahadevan D, Barton GJ, et al. 990 Prediction of domain organisation and secondary structure of thyroid peroxidase, a human autoantigen involved in destructive thyroiditis. FEBS Letts. 266:133-141.
24. Banga JP, Sutton BJ, Barton GJ, Mahadevan D, Sakdanha J, McGregor AM. 1991 Thyroid peroxidase: sequence comparison around proposed active site regions with other immunologically related peroxidases. In: Gordon A, Gross J, Hennemann G, eds. Progress in thyroid research. Rotherdam: A.A. Balkema; 433-436.
25. Shong YK, Finke R, Schleusener H. 1994 Evidence for an autoantigenic role of the TPO variant that lacks exon 10 (TPO-2). J Endocrinol Invest 17[Suppl 1]:17.
26. Finke R, Shong YK, Liu L, Haubruck H, Kotulla P. 1996 Anti-TPO autoantibodies are not directed against TPO variant lacking exon 10 (TPO-2). J Endocrinol Invest 19[Suppl 6]:20.
27. Cetani F, Costagliola S, Tonacchera M, Panneels V, Vassart G, Ludgate M. 1995 The thyroid peroxidase doublet is not produced by alternative splicing. Mol Cell Endocrinol. 115:125-132.
28. Ewins DL, Tomlinson RWS, Barnett PS, McGregor A M, Banga JP. 1992 Determination of epitope specificities of monoclonal antibodies to thyroid peroxidase using recombinant antigen preparations. Autoimmunity. 11:141-149.
29. Kiso Y, Furmaniak J, Morteo C, Rees Smith B. 1992 Analysis of carbohydrate residues on human thyroid peroxidase (TPO) and thyroglobulin (Tg) and effects of deglycosylation, reduction and unfolding on autoantibody binding. Autoimmunity. 12:259-269.
30. Wilson IA, Stanfield RL. 1994 Antibody-antigen interaction: new structures and new conformational changes. Curr Opin Struc Biol. 4:857-867.
31. Gardas A, Sohi MK, Sutton BJ, McGregor AM, Banga JP. 1997 Purification and crystallisation of the autoantigen, thyroid peroxidase from Graves' thyroid tissue. Biochem Biophys Res Commun., 234:366-370.
32. Zeng J, Fenna R E. 1992 X-ray crystal structure of canine myeloperoxidase at 3A resolution. J Mol Biol. 226:185-207.
33. Baker JR, Arscott P, Johnson J. 1994 An analysis of the structure and antigenicity of different forms of human thyroid peroxidase. Thyroid. 4:173-178.