Brain and plasma exposure profiling in early drug discovery using cassette administration and fast liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 34, Issue 2, 2004, Pages 359-368

  Zhang, Mei Yi ^a   Kerns, Edward ^a   McConnell, Oliver ^a   Sonnenberg Reines, June ^a   Zaleska, Margaret M ^a   Jacobsen, J Steven ^a   Butera, John ^a   Kreft, Anthony ^a  

^a PFIZER INC   (United States)

Author keywords

Biological internal standard; Cassette administration; Early in vivo brain and plasma exposure; Fast liquid chromatography tandem mass spectrometry

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG POTENCY; FLOW RATE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRECIPITATION; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; STANDARDIZATION;

EID: 0842287429     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00523-5     Document Type: Article

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