-
1
-
-
0021118703
-
Quantitative analysis of dose - Effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P (1984) Quantitative analysis of dose - effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
2
-
-
0035874074
-
Unique pattern of ET-743 activity in different cellular systems with defined deficiences in DNA-repair pathways
-
Damia G, Silvestri S, Carrassa L, Filliberti L, Faircloth GT, Liberi G, Foiani M, D'Incalci M (2001) Unique pattern of ET-743 activity in different cellular systems with defined deficiences in DNA-repair pathways. Int J Cancer 92: 583-588
-
(2001)
Int J Cancer
, vol.92
, pp. 583-588
-
-
Damia, G.1
Silvestri, S.2
Carrassa, L.3
Filliberti, L.4
Faircloth, G.T.5
Liberi, G.6
Foiani, M.7
D'Incalci, M.8
-
3
-
-
0036270843
-
ET-743: The US experience in sarcomas of soft tissues
-
Demetri GD (2002) ET-743: the US experience in sarcomas of soft tissues. Anticancer Drugs 13(Suppl 1): S7-S9
-
(2002)
Anticancer Drugs
, vol.13
, Issue.1 SUPPL.
-
-
Demetri, G.D.1
-
4
-
-
18444404938
-
Unique features of the mode of action of ET-743
-
D'Incalci M, Erba E, Damia G, Galliera E, Carrassa L, Marchini S, Mantovani R, Tognon G, Fruscio R, Jimeno J, Faircloth GT (2002) Unique features of the mode of action of ET-743. Oncologist 7: 210-216
-
(2002)
Oncologist
, vol.7
, pp. 210-216
-
-
D'Incalci, M.1
Erba, E.2
Damia, G.3
Galliera, E.4
Carrassa, L.5
Marchini, S.6
Mantovani, R.7
Tognon, G.8
Fruscio, R.9
Jimeno, J.10
Faircloth, G.T.11
-
5
-
-
0035146702
-
Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
-
Erba E, Bergamaschi D, Bassano L, Damia G, Ronzoni S, Faircloth GT, D'Incalci M (2001) Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer 37: 97-105
-
(2001)
Eur J Cancer
, vol.37
, pp. 97-105
-
-
Erba, E.1
Bergamaschi, D.2
Bassano, L.3
Damia, G.4
Ronzoni, S.5
Faircloth, G.T.6
D'Incalci, M.7
-
6
-
-
0037096739
-
Ecteinascidin-743 inhibits activated but not constitutive transcription
-
Friedman D, Hu Z, Kolb EA, Gorfajn B, Scotto KW (2002) Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res 62: 3377-3381
-
(2002)
Cancer Res
, vol.62
, pp. 3377-3381
-
-
Friedman, D.1
Hu, Z.2
Kolb, E.A.3
Gorfajn, B.4
Scotto, K.W.5
-
7
-
-
0034676314
-
Increased DNA binding specificity for antitumor ecteinascidin 743 through protein - DNA interactions
-
Garcia Nieto R, Manzanares I, Cuevas C, Gago F (2000) Increased DNA binding specificity for antitumor ecteinascidin 743 through protein - DNA interactions. J Med Chem 43: 4367-4369
-
(2000)
J Med Chem
, vol.43
, pp. 4367-4369
-
-
Garcia Nieto, R.1
Manzanares, I.2
Cuevas, C.3
Gago, F.4
-
8
-
-
0036166907
-
The use of chemoradiotherapy in oesophageal cancer
-
Geh JI (2002) The use of chemoradiotherapy in oesophageal cancer. Eur J Cancer 38: 300-313
-
(2002)
Eur J Cancer
, vol.38
, pp. 300-313
-
-
Geh, J.I.1
-
9
-
-
0031733644
-
In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743)
-
Ghielmini M, Colli E, Erba E, Bergamaschi D, Pampallona S, Jimeno J, Faircloth G, Sessa C (1998) In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743). Ann Oncol 9: 989-993
-
(1998)
Ann Oncol
, vol.9
, pp. 989-993
-
-
Ghielmini, M.1
Colli, E.2
Erba, E.3
Bergamaschi, D.4
Pampallona, S.5
Jimeno, J.6
Faircloth, G.7
Sessa, C.8
-
10
-
-
0032693607
-
High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer
-
Hendriks HR, Fiebig HH, Giavazzi R, Langdon SP, Jimeno JM, Faircloth GT, European Osteosarcoma Intergroup (EOI) (1999) High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer. Ann Oncol 10: 1233-1240
-
(1999)
Ann Oncol
, vol.10
, pp. 1233-1240
-
-
Hendriks, H.R.1
Fiebig, H.H.2
Giavazzi, R.3
Langdon, S.P.4
Jimeno, J.M.5
Faircloth, G.T.6
-
11
-
-
0036167369
-
Biological basis for chemo-radiotherapy interactions
-
Hennequin C, Favaudon V (2002) Biological basis for chemo-radiotherapy interactions. Eur J Cancer 38: 223-230
-
(2002)
Eur J Cancer
, vol.38
, pp. 223-230
-
-
Hennequin, C.1
Favaudon, V.2
-
12
-
-
0031766324
-
In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients
-
Izbicka E, Lawrence R, Raymond E, Eckhardt G, Faircloth G, Jimeno J, Clark G, Von Hoff DD (1998) In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients. Ann Oncol 9: 981-987
-
(1998)
Ann Oncol
, vol.9
, pp. 981-987
-
-
Izbicka, E.1
Lawrence, R.2
Raymond, E.3
Eckhardt, G.4
Faircloth, G.5
Jimeno, J.6
Clark, G.7
Von Hoff, D.D.8
-
13
-
-
0030453986
-
Progress in the acquisition of new marine-derived anticancer compounds: Development of ecteinascidin-743
-
Jimeno JM, Faircloth G, Cameron L, Meely K, Vega E, Gomez A, Fernandez Sousa-Faro JM, Rinehart K (1996) Progress in the acquisition of new marine-derived anticancer compounds: development of ecteinascidin-743. Drugs Future 21: 1155-1165
-
(1996)
Drugs Future
, vol.21
, pp. 1155-1165
-
-
Jimeno, J.M.1
Faircloth, G.2
Cameron, L.3
Meely, K.4
Vega, E.5
Gomez, A.6
Fernandez Sousa-Faro, J.M.7
Rinehart, K.8
-
14
-
-
0036276942
-
A phase III randomized trial of combined chemoradiotherapy versus radiotherapy alone in locally advanced non-small-cell lung cancer
-
Kim TY, Yang SH, Lee SH, Park YS, Im YH, Kang WK, Ha SH, Park CI, Heo DS, Bang YJ, Kim NK (2002) A phase III randomized trial of combined chemoradiotherapy versus radiotherapy alone in locally advanced non-small-cell lung cancer. Am J Clin Oncol Cancer Clin Trials 25: 238-243
-
(2002)
Am J Clin Oncol Cancer Clin Trials
, vol.25
, pp. 238-243
-
-
Kim, T.Y.1
Yang, S.H.2
Lee, S.H.3
Park, Y.S.4
Im, Y.H.5
Kang, W.K.6
Ha, S.H.7
Park, C.I.8
Heo, D.S.9
Bang, Y.J.10
Kim, N.K.11
-
15
-
-
0009424924
-
Consistent evidence of activity of ecteinascidin (ET-743) in pretreated, advanced soft tissue sarcoma (ASTS): Results from a pooled analysis of three pivotal phase II clinical trials (p2ct) and safety profile of a 24 h infusion schedule
-
Le Cesne A, Misset JL, Demetri G, Lopez-Martin JA, Blay JY, van Oosterom A, Judson I, Brain E, Yovine A, Maki R, Gomez J, Guzman C (2001) Consistent evidence of activity of ecteinascidin (ET-743) in pretreated, advanced soft tissue sarcoma (ASTS): results from a pooled analysis of three pivotal phase II clinical trials (p2ct) and safety profile of a 24 h infusion schedule. Eur J Cancer 37(Suppl 6): 34
-
(2001)
Eur J Cancer
, vol.37
, Issue.6 SUPPL.
, pp. 34
-
-
Le Cesne, A.1
Misset, J.L.2
Demetri, G.3
Lopez-Martin, J.A.4
Blay, J.Y.5
Van Oosterom, A.6
Judson, I.7
Brain, E.8
Yovine, A.9
Maki, R.10
Gomez, J.11
Guzman, C.12
-
16
-
-
0029822071
-
Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neck
-
Leonard CE, Chan DC, Chou TC, Kumar R, Bunn PA (1996) Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neck. Cancer Res 56: 5198-5204
-
(1996)
Cancer Res
, vol.56
, pp. 5198-5204
-
-
Leonard, C.E.1
Chan, D.C.2
Chou, T.C.3
Kumar, R.4
Bunn, P.A.5
-
17
-
-
0034813203
-
Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: Identification of ecteinascidin-743 as a potent cytotoxic agent
-
Li WW, Takahashi N, Jhanwar S, Cordon Cardo C, Elisseyeff Y, Jimeno J, Faircloth G, Bertino JR (2001) Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent. Clin Cancer Res 7: 2908-2911
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2908-2911
-
-
Li, W.W.1
Takahashi, N.2
Jhanwar, S.3
Cordon Cardo, C.4
Elisseyeff, Y.5
Jimeno, J.6
Faircloth, G.7
Bertino, J.R.8
-
18
-
-
0036598356
-
Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer - A meta-analysis
-
Lukka H, Hirte H, Fyles A, Thomas G, Elit L, Johnston M, Fung Kee Fung M, Browman G (2002) Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer - a meta-analysis. Clin Oncol 14: 203-212
-
(2002)
Clin Oncol
, vol.14
, pp. 203-212
-
-
Lukka, H.1
Hirte, H.2
Fyles, A.3
Thomas, G.4
Elit, L.5
Johnston, M.6
Fung Kee Fung, M.7
Browman, G.8
-
19
-
-
0032542724
-
Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2
-
Moore BM, Seaman FC, Wheelhouse RT, Hurley LH (1998) Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2. J Am Chem Soc 120: 2490-2491
-
(1998)
J Am Chem Soc
, vol.120
, pp. 2490-2491
-
-
Moore, B.M.1
Seaman, F.C.2
Wheelhouse, R.T.3
Hurley, L.H.4
-
21
-
-
24844457954
-
Yondelis™ (ET-743, trabectedin) antitumor activity in ovarian cancer patients pretreated with platinum-taxane regimens (50PD)
-
Parma G, Bauer J, Noberasco C, Perotti A, Izquierdo M, Jimeno J, Marsoni S, Colombo N, Capri G, Sessa C (2003) Yondelis™ (ET-743, trabectedin) antitumor activity in ovarian cancer patients pretreated with platinum-taxane regimens (50PD). Ann Oncol 14(Suppl 3): iii52
-
(2003)
Ann Oncol
, vol.14
, Issue.3 SUPPL.
-
-
Parma, G.1
Bauer, J.2
Noberasco, C.3
Perotti, A.4
Izquierdo, M.5
Jimeno, J.6
Marsoni, S.7
Colombo, N.8
Capri, G.9
Sessa, C.10
-
22
-
-
0037364872
-
Comparison of the sulforhodamine B test and the clonogenic assay for in vitro chemoradiation studies
-
Pauwels B, Korst AEC, De Pooter CMJ, Pattyn GGO, Lambrechts HAJ, Baay MFD, Lardon F, Vermorken JB (2003) Comparison of the sulforhodamine B test and the clonogenic assay for in vitro chemoradiation studies. Cancer Chemother Pharmacol 51: 221-226
-
(2003)
Cancer Chemother Pharmacol
, vol.51
, pp. 221-226
-
-
Pauwels, B.1
Korst, A.E.C.2
De Pooter, C.M.J.3
Pattyn, G.G.O.4
Lambrechts, H.A.J.5
Baay, M.F.D.6
Lardon, F.7
Vermorken, J.B.8
-
23
-
-
0034681783
-
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data
-
Pignon JP, Bourhis J, Domenge C, Designe L (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Lancet 355: 949-955
-
(2000)
Lancet
, vol.355
, pp. 949-955
-
-
Pignon, J.P.1
Bourhis, J.2
Domenge, C.3
Designe, L.4
-
24
-
-
0029838307
-
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ectainiascidin 743, a potent antitumor compound from the caribbean tunicate ecteinascidia turbinata
-
Pommier Y, Kohlhagen G, Bailly C, Waring M, Mazumder A, Kohn KW (1996) DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ectainiascidin 743, a potent antitumor compound from the caribbean tunicate ecteinascidia turbinata. Biochemistry 35: 13303-13309
-
(1996)
Biochemistry
, vol.35
, pp. 13303-13309
-
-
Pommier, Y.1
Kohlhagen, G.2
Bailly, C.3
Waring, M.4
Mazumder, A.5
Kohn, K.W.6
-
25
-
-
0036170561
-
Chemoradiotherapy for cervical cancer
-
Rose PG (2002) Chemoradiotherapy for cervical cancer. Eur J Cancer 38: 270-278
-
(2002)
Eur J Cancer
, vol.38
, pp. 270-278
-
-
Rose, P.G.1
-
26
-
-
0013973616
-
X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells
-
Sinclair WK, Morton RA (1966) X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat Res 29: 450-474
-
(1966)
Radiat Res
, vol.29
, pp. 450-474
-
-
Sinclair, W.K.1
Morton, R.A.2
-
27
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82: 1107-1112
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
28
-
-
0035281641
-
Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
-
Taamma A, Misset J L, Riofrio M, Guzman C, Brain E, Lopez Lazaro L, Rosing H, Jimeno J M, Cvitkovic E (2001) Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol 19: 1256-1265
-
(2001)
J Clin Oncol
, vol.19
, pp. 1256-1265
-
-
Taamma, A.1
Misset, J.L.2
Riofrio, M.3
Guzman, C.4
Brain, E.5
Lopez Lazaro, L.6
Rosing, H.7
Jimeno, J.M.8
Cvitkovic, E.9
-
29
-
-
17944374027
-
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
-
Takebayashi Y, Pourquier P, Zimonjic DB, Nakayama K, Emmert S, Ueda T, Urasaki Y, Kanzaki A, Akiyama S, Popescu N, Kraemer KH, Pommier Y (2001) Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med 7: 961-966
-
(2001)
Nat Med
, vol.7
, pp. 961-966
-
-
Takebayashi, Y.1
Pourquier, P.2
Zimonjic, D.B.3
Nakayama, K.4
Emmert, S.5
Ueda, T.6
Urasaki, Y.7
Kanzaki, A.8
Akiyama, S.9
Popescu, N.10
Kraemer, K.H.11
Pommier, Y.12
-
30
-
-
0000477631
-
X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells
-
Terasima R, Tolmach LJ (1963) X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science 140: 490-492
-
(1963)
Science
, vol.140
, pp. 490-492
-
-
Terasima, R.1
Tolmach, L.J.2
-
31
-
-
0020530724
-
A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis
-
Vindelov LL, Christensen IJ, Nissen NI (1983) A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3: 323-327
-
(1983)
Cytometry
, vol.3
, pp. 323-327
-
-
Vindelov, L.L.1
Christensen, I.J.2
Nissen, N.I.3
-
32
-
-
0009371785
-
Preliminary results of phase II study of ecteinascidin-743 (ET-743) with the 24h (H) continuous infusion (CI) Q3weeks schedule in pretreated advanced/metastatic breast cancer (A/MBC) patients (Pts)
-
Amsterdam, The Netherlands
-
Zelek L, Yovine A, Brain E (2000) Preliminary results of phase II study of ecteinascidin-743 (ET-743) with the 24h (H) continuous infusion (CI) Q3weeks schedule in pretreated advanced/metastatic breast cancer (A/MBC) patients (Pts). Proceedings of the 11th NCI EORTC-AACR Symposium on New Drugs in Cancer Therapy, Amsterdam, The Netherlands, p. 85a.
-
(2000)
Proceedings of the 11th NCI EORTC-AACR Symposium on New Drugs in Cancer Therapy
-
-
Zelek, L.1
Yovine, A.2
Brain, E.3
-
33
-
-
0033566150
-
Ecteinascidin 743: A minor groove alkylator that bends DNa toward the major groove
-
Zewail Foote M, Hurley LH (1999) Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem 42: 2493-2497
-
(1999)
J Med Chem
, vol.42
, pp. 2493-2497
-
-
Zewail Foote, M.1
Hurley, L.H.2
-
34
-
-
0035199322
-
The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent
-
Zewail Foote M, Li VS, Kohn H, Bearss D, Guzman M, Hurley LH (2001) The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent. Chem Biol 8: 1033-1049
-
(2001)
Chem Biol
, vol.8
, pp. 1033-1049
-
-
Zewail Foote, M.1
Li, V.S.2
Kohn, H.3
Bearss, D.4
Guzman, M.5
Hurley, L.H.6
|