Presentation assessment of minor histocompatibility antigens by predictive proteasomal cleavage analysis

Annals of Hematology

Volumn 83, Issue 2, 2004, Pages 107-113

  Khattab, B ^a   Eiz Vesper, B ^a   Ganser, A ^a   Hertenstein, B ^a   Blasczyk, Rainer ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Allogeneic stem cell transplantation; Minor histocompatibility antigens; Prediction; Proteasomal processing

Indexed keywords

AMINO ACID; EPITOPE; HLA ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MINOR HISTOCOMPATIBILITY ANTIGEN; PROTEASOME;

ACCURACY; ALGORITHM; ALLELE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME DEGRADATION; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HLA MATCHING; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN POLYMORPHISM; PROTEIN PROCESSING; RELIABILITY; SINGLE NUCLEOTIDE POLYMORPHISM; Y CHROMOSOME;

ALGORITHMS; AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; BINDING SITES; CHROMOSOMES; CYSTEINE ENDOPEPTIDASES; DATABASES, GENETIC; EPITOPES; HUMANS; IMMUNOGENETICS; MICE; MINOR HISTOCOMPATIBILITY ANTIGENS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PEPTIDE FRAGMENTS; PREDICTIVE VALUE OF TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 0742324415     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-003-0791-1     Document Type: Article

References (37)

1. Beninga J, Rock KL, Goldberg AL (1998) Interferon gamma can stimulate post-proteasomal trimming of the N-terminus of an antigenic peptide by inducing leucine aminopeptidase. J Biol Chem 273:18734-18742
2. Brickner AG, Warren EH, Caldwell JA, Akatsuka Y, Golovina TN, Zarling AL, Shabanowitz J, Eisenlohr LC, Hunt DF, Engelhard VH, Riddell SR (2001) The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. J Exp Med 193:195-206
3. Brossart P, Spahlinger B, Grunebach F, Stuhler G, Reichardt VL, Kanz L, Brugger (1999) Induction of minor histocompatibility antigen HA-1-specific cytotoxic T cells for the treatment of leukemia after allogeneic stem cell transplantation. Blood 94:4374-4376
4. Brown GM, Furlong RA, Sargent CA, Erickson RP, Longepied G, Mitchell M, Jones MH, Hargreave TB, Cooke HJ, Affara NA (1998) Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Hum Mol Genet 7:97-107
5. den Haan JM, Meadows LM, Wang W, Pool J, Blokland E, Bishop TL, Reinhardus C, Shabanowitz J, Offringa R, Hunt DF, Engelhard VH, Gouly E (1998) The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science 279:1054-1057
6. Dolstra H, Fredfix H, Maas F, Coulie PG, Brasseur F, Mensink E, Adema GJ, de Witte TM, Figdor CG, van de Wiel-van Kemenade E (1999) A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. J Exp Med 189:301-308
7. Dolstra H, de Rijke B, Fredrix H, Balas A, Maas F, Scherpen F, Aviles MJ, Vicario JL, Beekman NJ, Ossendorp F, de Witte TM, van de Wiel-van Kemenade E (2002) Bi-directional allelic recognition of the human minor histocompatibility antigen HB-1 by cytotoxic T lymphocytes. Eur J Immunol 32:2748-2758
8. Elliott T, Willis A, Cerundolo V, Townsend A (1995) Processing of major histocompatibility class I restricted antigens in the endoplasmic reticulum. J Exp Med 181:1481-1491
9. Frisan T, Levitsky V, Masucci MG (2000) Variations in protesome subunit composition and enzymatic activity in B-lymphoma lines and normal B cells. Int J Cancer 88:881-888
10. Geier E, Pfeifer G, Wilm M, Lucchiari-Hartz M, Baumeister W, Eichmann K, Niedermann G (1999) A giant protease with potential to substitute for some functions of the proteasome. Science 283:978-981
11. Goldberg AL Cascio P, Saric T, Rock KL (2002) The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. Mol Immunol 39:147-164
12. Herberts CA, Stittelaar KJ, van der Heeft E, van Gaans-van den Brink J, Polen MCM, Roholl PJM, van Alphen LJW, Melief CJM, de Jong APJM, van Els CACM (2001) A measle virus glycoprotein-derived human CTL epitope is abundantly presented via the proteasomal-dependent MHC class I processing pathway. J Gen Virol 82:2131-2142
13. Kisselev AF, Akopian TN, Woo KM, Goldberg AL (1999) The sizes of peptides generated from protein by mammalian 26 and 20S proteasomes. Implications for understanding the degradative mechanism and antigen presentation. J Biol Chem 274:3363-3371
14. + T cell-mediated autoimmunity. J Exp Med 195:983-990
15. Kuttler C, Nussbaum AK, Dick TP, Rammensee HG, Schild H, Hadeler KP (2000) An algorithm for the prediction of proteasomal cleavages. J Mol Biol 298:417-429
16. Lucchiari-Hartz M, van Endert PM, Lauvau G, Maier R, Meyerhans A, Mann D, Eichmann K, Niedermann G (2000) Cytotoxic T lymphocyte epitopes of HIV-1 Nef: generation of multiple definitive major histocompatibility complex class I ligands by proteasomes. J Exp Med 191:239-252
17. Luckey CJ, King GM, Marto JA, Venketeswaran S, Maier BF, Crotzer VL, Colella TA, Shabanowitz J, Hunt DF, Engelhard VH (1998) Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol. J Immunol 161:112-121
18. Makoto M, Warren EH, Riddell SR (2003) A human minor histocompatibility antigen resulting from differential expression due to gene deletion. J Exp Med 197:1279-1289
19. Meadows L, Wang W, den Haan JM, Blokland E, Reinhardus C, Drijfhout JW, Shabanowitz J, Pierce R, Agulnik AI, Bishop CE, Hunt DF, Goulmy E, Engelhard VH (1997) The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 6:273-281
20. Mo XY, Cascio P, Lemerise K, Goldberg AL, Rock K (1999) Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. J Immunol 163:5851-5859
21. Mutis T, Goulmy E (2000) Minor histocompatibility antigens. In: Barrett J, Jiang Y-Z (eds) Allogeneic immuntherapy for malignant diseases. Marcel Dekker, New York, pp 119
22. Nussbaum AK, Kuttler C, Hadeler K-P, Rammensee H-G, Schild H (2001) PAProC: a prediction algorithm for proteasomal cleavages available on the WWW. Immunogenetics 53:87-94
23. Ossendorp F, Eggers M, Neisig A, Ruppert T, Groettrup M, Sijts A, Mengede E, Kloetzel PM, Neefjes J, Koszinowski U, Melief C (1996) A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. Immunity 5:115-124
24. Pierce RA, Field ED, den Haan JMM, Caldwell JA, White FM, Marto JA, Wang W, Frost LM, Blokland E, Reinhardus C, Shabanowitz J, Hunt DF, Goulmy E, Engelhard VH (1999) Cutting edge: the HLA-A*0101-restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique. J Immunol 163:6360-6364
25. Pierce RA, Field WD, Mutis T, Golovina TN, von Kap-Herr C, Wilke M, Pool J, Shabanowitz J, Pettenati MJ, Eisenlohr LC, Hunt DF, Golumy E, Engelhard VH (2001) The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein. J Immunol 167:3223-3230
26. Randolph SB, Warren EH, Riddell SR (2002) Identification of novel minor histocompatibility antigens encoded by the Y chromosome gene, UTY. Blood 100: Proceedings of the 44th Annual Meeting of the American Society of Hematology (Abstract 2421)
27. Rock KL, York IA, Saric T, Goldberg AL (2002) Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol 80:1-70
28. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL (2002) An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol 3:1169-1176
29. Serwold T, Gonzalez F, Kim J, Jacob R, Shastri N (2002) ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature 419:480-483
30. Spierings E, Brickner AG, Caldwell JA, Zegveld S, Tatsis N, Blokland E, Pool J, Pierce RA, Mollah S, Shabanowitz J, Eisenlohr LC, van Veelen P, Ossendorp F, Hunt DF, Goulmy E, Engelhard VH (2003) The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. Blood Mar 27 (epub ahead of print)
31. Stoltze L, Dick TP, Deeg M, Pommerl B, Rammensee HG, Schild H (1998) Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities. Eur J Immunol 28:4029-4036
32. Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H (2000) Two new proteases in the MHC class I processing pathway. Nat Immunol 2000 1:413-418
33. Toes RE, Nussbaum AK, Degermann S, Schirle M, Emmerich NP, Kraft M, Laplace C, Zwinderman A, Dick TP, Muller J, Schonfisch B, Schmid C, Fehling HJ, Stevanovic S, Rammensse HG, Schild H (2001) Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. J Exp Med 194:1-12
34. Vogt MH, de Paus RA, Voogt PJ, Willemze R, Falkenburg JHF (2000) DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection. Blood 95:1100-1105
35. Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (2000) UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition. Blood 96:3126-3132
36. Wang W, Meadows LR, den Haan JM, Sherman NE, Chen Y, Blokland E, Shabanowitz J, Agulnik AI, Hendrickson RC, Bishop CE, et al (1995) Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. Science 269:1588-1590
37. Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, Stankey KA, Greenberg PD, Riddell SR (2000) The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen. J Immunol 164:2807-2814