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Volumn 66, Issue 8, 2003, Pages 1619-1625

Neurofibrillary degeneration of the Alzheimer-type: An alternate pathway to neuronal apoptosis?

Author keywords

AD; Alzheimer's disease; Amyloid precursor protein; APP; Cdk; Cdk5; Cell cycle; Cyclin dependent kinase; Neurofibrillary tangles; Neurofibrillary tangles (NFT); Neuronal death; NFT; Paired helical filaments; PHF; Pin1; Tau phosphorylation

Indexed keywords

BIOLOGICAL MARKER; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 6; EPITOPE; PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN; PROTEIN P25; TAU PROTEIN; UNCLASSIFIED DRUG; NIMA INTERACTING PEPTIDYLPROLYL ISOMERASE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE;

EID: 0642375800     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00533-1     Document Type: Conference Paper
Times cited : (45)

References (52)
  • 1
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
    • The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 1997;18:S1-2.
    • (1997) Neurobiol Aging , vol.18
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297(5580):2002;353- 356.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 3
    • 1642355567 scopus 로고    scopus 로고
    • Tauopathy upstream of the amyloid cascade in Alzheimer's disease
    • Delacourte A., Sergeant N., Buée L. Tauopathy upstream of the amyloid cascade in Alzheimer's disease. Brain Aging. 2:2002;16-17.
    • (2002) Brain Aging , vol.2 , pp. 16-17
    • Delacourte, A.1    Sergeant, N.2    Buée, L.3
  • 6
    • 0025992295 scopus 로고
    • A topographical pathway by which histopathological lesions disseminate through the brain of patients with Alzheimer's disease
    • Fewster P.H., Griffin-Brooks S., MacGregor J., Ojalvo-Rose E., Ball A. A topographical pathway by which histopathological lesions disseminate through the brain of patients with Alzheimer's disease. Dementia. 2:1991;121-132.
    • (1991) Dementia , vol.2 , pp. 121-132
    • Fewster, P.H.1    Griffin-Brooks, S.2    MacGregor, J.3    Ojalvo-Rose, E.4    Ball, A.5
  • 7
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles neurofilaments and APP vesicles in neurons and enhances oxidative stress
    • Stamer K., Vogel R., Thies E., Mandelkow E., Mandelkow E.M. Tau blocks traffic of organelles neurofilaments and APP vesicles in neurons and enhances oxidative stress. J. Cell Biol. 156(6):2002;1051-1063.
    • (2002) J. Cell Biol. , vol.156 , Issue.6 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 8
    • 0034672421 scopus 로고    scopus 로고
    • Alzheimer's disease: A dysfunction of the amyloid precursor protein
    • Neve R.L., McPhie D.L., Chen Y. Alzheimer's disease: a dysfunction of the amyloid precursor protein. Brain Res. 886:2000;54-66.
    • (2000) Brain Res. , vol.886 , pp. 54-66
    • Neve, R.L.1    McPhie, D.L.2    Chen, Y.3
  • 9
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for DNA fragmentation in neurons in the Alzheimer's disease brain
    • Su J.H., Anderson A.J., Cummings B.J., Cotman C.W. Immunohistochemical evidence for DNA fragmentation in neurons in the Alzheimer's disease brain. NeuroReport. 5:1994;2529-2533.
    • (1994) NeuroReport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 10
  • 11
    • 0034920836 scopus 로고    scopus 로고
    • Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies
    • Broe M., Shepherd C.E., Milward E.A., Halliday G.M. Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol. 101(6):2001;616-624.
    • (2001) Acta Neuropathol. , vol.101 , Issue.6 , pp. 616-624
    • Broe, M.1    Shepherd, C.E.2    Milward, E.A.3    Halliday, G.M.4
  • 12
    • 2642680857 scopus 로고    scopus 로고
    • Alzheimer's disease: DNA fragmentation indicates increased neuronal vulnerability but not apoptosis
    • Stadelmann C., Bruck W., Bancher C., Jellinger K., Lassmann H. Alzheimer's disease: DNA fragmentation indicates increased neuronal vulnerability but not apoptosis. J. Neuropathol. Exp. Neurol. 57:1998;456-464.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 456-464
    • Stadelmann, C.1    Bruck, W.2    Bancher, C.3    Jellinger, K.4    Lassmann, H.5
  • 13
    • 0030036176 scopus 로고    scopus 로고
    • Copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells resulting from direct oxidation by the hydroxyl radical
    • Tsang S.Y., Tam S.C., Bremner I., Burkitt M.J. Copper-1, 10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells resulting from direct oxidation by the hydroxyl radical. Biochem. J. 317:1996;13-16.
    • (1996) Biochem. J. , vol.317 , pp. 13-16
    • Tsang, S.Y.1    Tam, S.C.2    Bremner, I.3    Burkitt, M.J.4
  • 14
    • 0028324310 scopus 로고
    • Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of Cyclin D1 during programmed cell death
    • Freeman R.S., Estus S., Johnson E.M. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron. 12(2):1994;343-355.
    • (1994) Neuron , vol.12 , Issue.2 , pp. 343-355
    • Freeman, R.S.1    Estus, S.2    Johnson, E.M.3
  • 15
    • 0029078677 scopus 로고
    • The induction of multiple cell cycle events precede target-related neuronal death
    • Herrup K., Busser J.C. The induction of multiple cell cycle events precede target-related neuronal death. Development. 121:1995;2385-2395.
    • (1995) Development , vol.121 , pp. 2385-2395
    • Herrup, K.1    Busser, J.C.2
  • 16
    • 0033570320 scopus 로고    scopus 로고
    • Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
    • Padmanabhan J., Park D.S., Greene L.A., Shelanski M.L. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J. Neurosci. 19:1999;8747-8756.
    • (1999) J. Neurosci. , vol.19 , pp. 8747-8756
    • Padmanabhan, J.1    Park, D.S.2    Greene, L.A.3    Shelanski, M.L.4
  • 17
    • 0034923671 scopus 로고    scopus 로고
    • Neuronal apoptosis at the G1/S cell cycle checkpoint
    • Liu D.X., Greene L.A. Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res. 305(2):2001;217-228.
    • (2001) Cell Tissue Res. , vol.305 , Issue.2 , pp. 217-228
    • Liu, D.X.1    Greene, L.A.2
  • 19
    • 0031737550 scopus 로고    scopus 로고
    • Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease
    • Arendt T., Holzer M., Gartner U. Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease. J. Neural. Transm. 105(8/9):1998;949-960.
    • (1998) J. Neural. Transm. , vol.105 , Issue.8-9 , pp. 949-960
    • Arendt, T.1    Holzer, M.2    Gartner, U.3
  • 20
    • 0037322816 scopus 로고    scopus 로고
    • Proline-directed phosphorylation and isomerization in mitotic regulation and Alzheimer's disease
    • Lu K.P., Liou Y.C., Vincent I. Proline-directed phosphorylation and isomerization in mitotic regulation and Alzheimer's disease. BioEssays. 25:2003;174-181.
    • (2003) BioEssays , vol.25 , pp. 174-181
    • Lu, K.P.1    Liou, Y.C.2    Vincent, I.3
  • 21
    • 0033634990 scopus 로고    scopus 로고
    • Cell cycle regulatory failure in neurones: Causes and consequences
    • Nagy Z. Cell cycle regulatory failure in neurones: causes and consequences. Neurobiol. Aging. 21:2000;761-769.
    • (2000) Neurobiol. Aging , vol.21 , pp. 761-769
    • Nagy, Z.1
  • 23
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I., Jicha G., Rosado M., Dickson D.W. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci. 17:1997;3588-3598.
    • (1997) J. Neurosci. , vol.17 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 24
    • 0031685160 scopus 로고    scopus 로고
    • Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease
    • Vincent I., Zheng J.H., Dickson D.W., Kress Y., Davies P. Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease. Neurobiol. Aging. 19:1998;287-296.
    • (1998) Neurobiol. Aging , vol.19 , pp. 287-296
    • Vincent, I.1    Zheng, J.H.2    Dickson, D.W.3    Kress, Y.4    Davies, P.5
  • 25
    • 0026595846 scopus 로고
    • Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
    • Goedert M., Spillantini M.G., Cairns N.J., Crowther R.A. Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron. 8(1):1992;159-168.
    • (1992) Neuron , vol.8 , Issue.1 , pp. 159-168
    • Goedert, M.1    Spillantini, M.G.2    Cairns, N.J.3    Crowther, R.A.4
  • 27
    • 0037051935 scopus 로고    scopus 로고
    • Modelling Alzheimer-specific abnormal Tau phosphorylation independently of GSK3β and pKA kinase activities
    • Delobel P., Flament S., Hamdane M., Delacourte A., Vilain J.P., Buée L. Modelling Alzheimer-specific abnormal Tau phosphorylation independently of GSK3β and pKA kinase activities. FEBS Lett. 516:2002;151-155.
    • (2002) FEBS Lett. , vol.516 , pp. 151-155
    • Delobel, P.1    Flament, S.2    Hamdane, M.3    Delacourte, A.4    Vilain, J.P.5    Buée, L.6
  • 28
    • 0032521599 scopus 로고    scopus 로고
    • Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase a at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation
    • Zheng-Fishhoffer Q., Biernat J., Mandelkow E.M., Illenberger S., Godemann R., Mandelkow E. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical- filament-like conformation. Eur. J. Biochem. 252:1998;542-552.
    • (1998) Eur. J. Biochem. , vol.252 , pp. 542-552
    • Zheng-Fishhoffer, Q.1    Biernat, J.2    Mandelkow, E.M.3    Illenberger, S.4    Godemann, R.5    Mandelkow, E.6
  • 29
    • 0037181485 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein Tau by stress-activated protein kinases in intact cells
    • Buée-Scherrer V., Goedert M. Phosphorylation of microtubule-associated protein Tau by stress-activated protein kinases in intact cells. FEBS Lett. 515:2002;151-154.
    • (2002) FEBS Lett. , vol.515 , pp. 151-154
    • Buée-Scherrer, V.1    Goedert, M.2
  • 30
    • 0030942149 scopus 로고    scopus 로고
    • Induction of a specific Tau Alzheimer epitope in SY-5Y neuroblastoma cells
    • Caillet-Boudin M.L., Delacourte A. Induction of a specific Tau Alzheimer epitope in SY-5Y neuroblastoma cells. NeuroReport. 8(1):1996;307-310.
    • (1996) NeuroReport , vol.8 , Issue.1 , pp. 307-310
    • Caillet-Boudin, M.L.1    Delacourte, A.2
  • 32
    • 0030062245 scopus 로고    scopus 로고
    • Mitotic mechanisms in Alzheimer's disease
    • Vincent I., Rosado M., Davies P. Mitotic mechanisms in Alzheimer's disease. J. Cell Biol. 132:1996;413-425.
    • (1996) J. Cell Biol. , vol.132 , pp. 413-425
    • Vincent, I.1    Rosado, M.2    Davies, P.3
  • 33
    • 0030783142 scopus 로고    scopus 로고
    • A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease
    • Jicha G.A., Lane E., Vincent I., Otvos L. Jr., Hoffmann R., Davies P. A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease. J. Neurochem. 69:1997;2087-2095.
    • (1997) J. Neurochem. , vol.69 , pp. 2087-2095
    • Jicha, G.A.1    Lane, E.2    Vincent, I.3    Otvos, L.Jr.4    Hoffmann, R.5    Davies, P.6
  • 34
    • 0033600242 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated Tau protein
    • Lu P.J., Wulf G., Zhou X.Z., Davies P., Lu K.P. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated Tau protein. Nature. 399(6738):1999;784-788.
    • (1999) Nature , vol.399 , Issue.6738 , pp. 784-788
    • Lu, P.J.1    Wulf, G.2    Zhou, X.Z.3    Davies, P.4    Lu, K.P.5
  • 35
    • 0033635551 scopus 로고    scopus 로고
    • Mitotic activation: A convergent mechanism for a cohort of neurodegenerative diseases
    • Husseman J.W., Nochlin D., Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol. Aging. 21:2000;815-828.
    • (2000) Neurobiol. Aging , vol.21 , pp. 815-828
    • Husseman, J.W.1    Nochlin, D.2    Vincent, I.3
  • 38
    • 0036937699 scopus 로고    scopus 로고
    • Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
    • Augustinack J.C., Schneider A., Mandelkow E.M., Hyman B.T. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol. 103:2002;26-35.
    • (2002) Acta Neuropathol. , vol.103 , pp. 26-35
    • Augustinack, J.C.1    Schneider, A.2    Mandelkow, E.M.3    Hyman, B.T.4
  • 39
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • Patrick G.N., Zukerberg L., Nikolic M., de la Monte S., Dikkes P., Tsai L.H. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature. 402(6762):1999;615-622.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    De La Monte, S.4    Dikkes, P.5    Tsai, L.H.6
  • 40
    • 0036703779 scopus 로고    scopus 로고
    • Deregulation of cdk5, hyperphosphorylation and cytoskeletal pathology in the Niemann-Pick type C murine model
    • Bu B., Li J., Davies P., Vincent I. Deregulation of cdk5, hyperphosphorylation and cytoskeletal pathology in the Niemann-Pick type C murine model. J. Neurosci. 22:2002;6515-6525.
    • (2002) J. Neurosci. , vol.22 , pp. 6515-6525
    • Bu, B.1    Li, J.2    Davies, P.3    Vincent, I.4
  • 42
    • 0030308965 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators
    • Tang D., Wang J. Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators. Prog. Cell Cycle Res. 2:1996;205-216.
    • (1996) Prog. Cell Cycle Res. , vol.2 , pp. 205-216
    • Tang, D.1    Wang, J.2
  • 46
    • 0037169479 scopus 로고    scopus 로고
    • Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function
    • Lu P.J., Zhou X.Z., Liou Y.C., Noel J.P., Lu K.P. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J. Biol. Chem. 277:2002;2381-2384.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2381-2384
    • Lu, P.J.1    Zhou, X.Z.2    Liou, Y.C.3    Noel, J.P.4    Lu, K.P.5
  • 48
    • 0034840950 scopus 로고    scopus 로고
    • Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
    • Ryo A., Nakamura M., Wulf G., Liou Y.C., Lu K.P. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3:2001;793-801.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 793-801
    • Ryo, A.1    Nakamura, M.2    Wulf, G.3    Liou, Y.C.4    Lu, K.P.5
  • 49
    • 0035796405 scopus 로고    scopus 로고
    • Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
    • Wulf G.M., Ryo A., Wulf G.G., Lee S.W., Niu T., Petkova V., Lu K.P. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 20:2001;3459-3472.
    • (2001) EMBO J. , vol.20 , pp. 3459-3472
    • Wulf, G.M.1    Ryo, A.2    Wulf, G.G.3    Lee, S.W.4    Niu, T.5    Petkova, V.6    Lu, K.P.7
  • 51
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1999;1501-1512.
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 52
    • 0037351048 scopus 로고    scopus 로고
    • Prolyl isomerase Pin1: A catalyst for oncogenesis and a potential therapeutic target in cancer
    • Ryo A., Liou Y.C., Lu K.P., Wulf G. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J. Cell Sci. 116:2003;773-783.
    • (2003) J. Cell Sci. , vol.116 , pp. 773-783
    • Ryo, A.1    Liou, Y.C.2    Lu, K.P.3    Wulf, G.4


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