Ligation of CD47 during Monocyte Differentiation into Dendritic Cells Results in Reduced Capacity for Interleukin-12 Production

Scandinavian Journal of Immunology

Volumn 59, Issue 1, 2004, Pages 50-57

  Johansson, U ^a,b   Londei, M ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CD47 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL STIMULATION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; HUMAN; HUMAN CELL; MONOCYTE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANABASINE; ANTIGENS, CD; ANTIGENS, CD47; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; LYMPHOCYTE CULTURE TEST, MIXED; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0442323296     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0300-9475.2004.01354.x     Document Type: Article

References (25)

1. Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 1998;16:365-96.
2. Reis e Sousa C, Yap G, Schulz O et al. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. Immunity 1999;11:637-47.
3. Kalinski P, Schuitemaker JH, Hilkens CM et al. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol 1999;162:3231-6.
4. Johansson U, Ivanyi J, Londei M. Inhibition of IL-12 production in human dendritic cells matured in the presence of Bacillus Calmette-Guerin or lipoarabinomannan. Immunol Lett 2001;77:63-6.
5. Rieser C, Papesh C, Herold M et al. Differential deactivation of human dendritic cells by endotoxin desensitization: role of tumor necrosis factor-alpha and prostaglandin E2. Blood 1998;91:3112-7.
6. Karp CL, Wysocka M, Ma X et al. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. Eur J Immunol 1998;28:3128-36.
7. Langenkamp A, Messi M, Lanzavecchia A, Sallusto F. Kinetics of dendritic cell activation, impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 2000;1:311-6.
8. Armant M, Avice MN, Hermann P et al. CD47 ligation selectively downregulates human interleukin 12 production. J Exp Med 1999;190:1175-82.
9. Demeure CE, Tanaka H, Mateo V et al. CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J Immunol 2000;164:2193-9.
10. Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 2001;11:130-5.
11. Gao AG, Lindberg FP, Dimitry JM et al. Thrombospondin modulates alpha v beta 3 function through integrin-associated protein. J Cell Biol 1996;135:533-44.
12. Seiffert M, Cant C, Chen Z et al. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood 1999;94:3633-43.
13. Vernon-Wilson EF, Kee WJ, Willis AC et al. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol 2000;30:2130-7.
14. Lindberg FP, Gresham HD, Reinhold MI, Brown EJ. Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding. J Cell Biol 1996;134:1313-22.
15. Pettersen RD, Hestdal K, Olafsen MK et al. CD47 signals T cell death. J Immunol 1999;162:7031-40.
16. Lamy L, Ticchioni M, Rouquette-Jazdanian AK et al. CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis. J Biol Chem 2003;278:23915-21.
17. Mateo V, Lagneaux L, Bron D et al. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat Med 1999;5:1277-84.
18. Johansson U, Higginbottom K, Londei M. CD47 ligation induces a rapid caspase-independent apoptosis-like cell death in human monocytes and dendritic cells. Scand J Immunol 2004;59:40-9.
19. + dendritic cells. Proc Natl Acad Sci USA 1996;93:2588-92.
20. Fadok VA, Bratton DL, Konowal A et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998;101:890-8.
21. Morelli AE, Larregina AT, Shufesky WJ et al. Internalization of circulating apoptosis cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood 2003;101:611-20.
22. Voll RE, Herrmann M, Roth EA et al. Immunosuppressive effects of apoptotic cells. Nature 1997;390:350-1.
23. Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol 1997;15:749-95.
24. Buttigleri S, Galetto A, Forno S et al. Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells. Int J Cancer 2003;106:516-20.
25. Mateo V, Brown EJ, Biron G et al. Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood 2002;100:2882-90.