Compare two methods of measuring DNA damage induced by photogenotoxicity of fluoroquinolones

Acta Pharmacologica Sinica

Volumn 25, Issue 2, 2004, Pages 171-175

  Zhang, Ting ^a   Li, Jun Ling ^a   Xin, Jian ^a   Ma, Xiao Chao ^a   Tu, Zeng Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Comet assay; Fluoroquinolones; Phototoxic dermatitis

Indexed keywords

CIPROFLOXACIN; LEVOFLOXACIN; LOMEFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ANIMAL CELL; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DNA SUPERCOILING; GENOTOXICITY; INTERMETHOD COMPARISON; NONHUMAN; PHOTODYNAMICS; PHOTOTOXICITY; ULTRAVIOLET A RADIATION;

ANIMALS; ANTI-INFECTIVE AGENTS; CELLS, CULTURED; CIPROFLOXACIN; COMET ASSAY; CRICETINAE; CRICETULUS; DNA; DNA DAMAGE; FIBROBLASTS; FLUOROQUINOLONES; OFLOXACIN; QUINOLONES; ULTRAVIOLET RAYS;

EID: 0442293852     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Zhanel GG, Ennis K, Vercaigne L, Walkty A, Gin AS, Embil J, et al. A critical review of the fluoroquinolones. Drugs 2002; 62: 13-59.
2. Kersten B, Zhang J, Brendler-Schwaab SY, Kasper P, Muller L. The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. Mutat Res 1999; 445: 55-71.
3. Klecak G, Urbach F, Urwyler H. Fluoroquinolone antibacterials enhance UVA-induced skin tumors. J Photochem Photobiol (B) 1997; 37: 174-81.
4. Gocke E, Albertini S, Chetelat AA, Kirchner S, Muster W. The photomutagenicity of fluoroquinolones and other drugs. Toxicol Lett 1998; 102-103: 375-81.
5. Umezawa N, Arakane K, Ryu A, Mashiko S, Hirobe M, Nagano T. Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents. Archives of Biochem Biophy 1997; 342: 275-81.
6. Guo JY, Tu ZH. Comet electrophoresis of blood nucleated cells in genotoxicity assessment. Acta Pharmacol Sin 1999; 20: 975-8.
7. Epe B, Pflaum M, Boiteux S. DNA damage induced by photosensitizers in cellular and cell-free systems. Mutat Res 1993; 299: 135-45.
8. Traynor NJ, Barratt MD, Lovell WW, Ferguson J, Gibbs NK. Comparison of an in vitro cellular phototoxicity model against controlled clinical trials of fluoroquinolone skin phototoxicity. Toxicol In Vitro 2000; 14: 275-83.
9. Chetelat AA, Albertini S, Gocke E. The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA damage (Comet assay). Mutagenesis 1996; 11: 497-504.
10. Reavy HJ, Traynor NJ, Gibbs NK. Photogenotoxicity of skin phototumorigenic fluoroquinolone antibiotics detected using the comet assay. Photochem Photobiol 1997; 66: 368-73.
11. Yamamoto T, Tsurumaki Y, Takei M, Hosaka M, Oomori Y. In vitro method for prediction of the phototoxic potentials of fluoroquinolones. Toxicol In Vitro 2001; 15: 721-7.
12. Marrot L, Agapakis-Causse C. Differences in the photogenotoxic potential of two fluoroquinolones as shown in diploid yeast strain (Saccharomyces cerevisae) and supercoiled plasmid DNA. Mutat Res 2000; 468: 1-9.
13. Ball P. Moxifloxacin (Avelox): an 8-methoxyquinolone antibacterial with enhanced potency. Int J Clin Pract 2000; 54: 329-32.
14. Zhang T, Li JL, Ma XC, Xin J, Tu ZH. Reliability of phototoxic tests of fluoroquinolones in vitro. Acta Pharmacol Sin 2003; 24: 453-9.
15. Spielmann H, Balls M, Dupuis J, Pape WJ, Pechovitch G, DeSilva O, et al. The international EU/COLIPA in vitro phototoxicity validation study: results of phase II (blind trial). part 1: the 3T3 NRU phototoxicity test. Toxicol In Vitro 1998; 12: 305-27.