Mutagenesis of Putative Catalytic and Regulatory Residues of Streptomyces chromofuscus Phospholipase D Differentially Modifies Phosphatase and Phosphodiesterase Activities

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52282-52289

  Zambonelli, Carlo ^a   Casali, Monica ^a,b   Roberts, Mary F ^a  

^a BOSTON COLLEGE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; HYDROLYSIS; MUTAGENESIS; ORGANIC ACIDS;

MUTANTS;

ENZYMES;

ASPARTIC ACID; CALCIUM ION; GLUTAMIC ACID; HISTIDINE; IRON; MANGANESE; METALLOPROTEIN; PHOSPHATASE; PHOSPHODIESTERASE; PHOSPHOLIPASE D;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY MECHANISM; STREPTOMYCES; STREPTOMYCES CHROMOFUSCUS;

ACID PHOSPHATASE; AMINO ACID SEQUENCE; ASPARTIC ACID; BINDING SITES; CALCIUM; CALORIMETRY; CATALYTIC DOMAIN; CIRCULAR DICHROISM; GLUTAMINE; GLYCOPROTEINS; HISTIDINE; HYDROLYSIS; IONS; IRON; KINETICS; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOLIPASE D; PHOSPHORIC DIESTER HYDROLASES; PHOSPHORIC MONOESTER HYDROLASES; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY; STREPTOMYCES; TIME FACTORS; ULTRAVIOLET RAYS;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES CHROMOFUSCUS; UNCULTURED ACTINOMYCETE;

EID: 0347993099     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310252200     Document Type: Article

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