The road less travelled: Taming phosphatases

Chemistry and Biology

Volumn 4, Issue 7, 1997, Pages 489-492

  Widlanski, Theodore S ^a   Myers, Jason K ^a   Stec, Boguslaw ^b   Holtz, Kathleen M ^b   Kantrowitz, Evan R ^b  

^a INDIANA UNIVERSITY   (United States)

^b BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS);

EID: 0031194321     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(97)90319-7     Document Type: Short Survey

References (15)

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3. Taylor, WP. & Widlanski, T.S. (1995). Charged with meaning - the structure and mechanism of phosphoprotein phosphatases. Chem. Biol. 2, 713-718.
4. Crans, D.C., Simone, C.M., Holz, R.C. & Que, L., (1992). Interaction of porcine uterine fluid purple acid-phosphatase with vanadate and vanadyl cation. Biochemistry 31, 11731-11739.
5. Saha, A.K., Crans, D.C., Pope, M.T., Simone, C.M. & Glew, R.H. (1991). Inhibition of human seminal fluid and Leishmania-Donovani phosphatases by molybdate heteropolyanions. J. Biol. Chem. 266, 3511-3517.
6. Cushman, D.W., Cheung, U.S., Sabo, E.F. & Ondetti, M.A. (1977). Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxalkanoyl and mercaptoalkanoyl amino acids. Biochemistry 16, 5464-5491.
7. Tatlock, J.H., et al., & Villafranca, J.E. (1997). Structure-based design of novel calcineurin (PP2B) inhibitors. Bioorg. Med. Chem. Lett. 7, 1007-1012.
8. Myers, J.K., Antonelli, S.M. & Widlanski, T.S. (1997). Motifs for metallophosphatase inhibition. J. Am. Chem. Soc. 119, 3163-3164.
9. Moran, E.J., et al., & Armstrong, R.W. (1995). Radio-frequency Tag encoded combinatorial library method for the discovery of tripeptidesubstituted cinnamic acid inhibitors of the protein-tyrosinephosphatase Ptp1B. J. Am. Chem. Soc. 117, 10787-10788.
10. Ye, B. & Burke, T.R. (1996). Synthesis of a difluorophosphonomethylcontaining phosphatase inhibitor designed from the X-ray structure of a Ptp1B-bound ligand. Tetrahedron 52, 9963-9970.
11. Taylor, W.P., Zhang, Z.-Y. & Widlanski, T.S. (1996). Quiescent affinity inactivators of protein tyrosine phosphatases. Bioorg. Med. Chem. 4, 1515-1520.
12. Myers, J.K. & Widlanski, T.S. (1993). Mechanism-based inactivation of prostatic acid-phosphatase. Science 262, 1451-1453.
13. Wang, O.P., Dechert, U., Jink, F. & Withers, S.G. (1994). Suicide inactivation of human prostatic acid-phosphatase and a phosphotyrosine phosphatase. Biochem. Biophys. Res. Commun. 200, 577-583.
14. Myers, J.K., Cohen, J.D. & Widlanski, T.S. (1995). Substituent effects on the mechanism-based inactivation of prostatic acid-phosphatase. J Am. Chem. Soc. 117, 11049-11054.
15. Stowell, J.K., Widlanski, T.S., Kutateladze T.G. & Raines, R.T. (1995). Mechanism-based inactivation of ribonuclease-A. J. Org. Chem. 60, 6930-6936.