Genetic variation in mRNA coding sequences of highly conserved genes

Physiological Genomics

Volumn 2001, Issue 5, 2001, Pages 113-118

  Ten Asbroek, Anneloor L M A ^a   Olsen, Jeffrey ^b   Housman, David ^c   Baas, Frank ^a   Stanton Jr , Vince ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Variagenics Inc   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Diversity; Human; Polymorphism; Single nucleotide polymorphisms

Indexed keywords

FUNGAL PROTEIN; MESSENGER RNA;

ARTICLE; CELL LINE; GENE; GENETIC VARIABILITY; GENETICS; HUMAN; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; YEAST;

CELL LINE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; FUNGAL PROTEINS; GENES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; VARIATION (GENETICS); YEASTS;

EID: 0347768059     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.2001.5.3.113     Document Type: Article

References (20)

1. Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, and Tiret L. Sequence diversity in 36 candidate genes for cardiovascular disorders. Am J Hum Genet 65: 183-191, 1999.
2. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Lane CR, Lim EP, Kalayanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, and Lander ES. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 22: 231-238, 1999.
3. Collins FS, Guyer MS, and Chakravarti A. Variations on a theme: cataloging human DNA sequence variation. Science 278: 1580-1581, 1997.
4. Cooper D, Krawczak M, and Antonarakis SE. The nature and mechanism of human gene mutation. In: The Metabolic Basis of Inherited Disease (7th ed.), edited by Scriver CR, Beaudet AL, Sly WS, and Valle D. 1995, p. 259-292.
5. Ewing B, Hillier L, Wendl MC, and Green P. Base-calling of automated sequencers traces using phred. I. Accuracy assessment. Genome Res 8: 175-185, 1998.
6. Ewing B and Green P. Base-calling of automated sequencers traces using phred. II. Error probabilities. Genome Res 8: 186-194, 1998.
7. Fraser CM, Gocayne JD, White O, Adams MD, Clayton RA, Fleischmann RD, Bult CJ, Kerlavage AR, Sutton G, Kelley JM, Fritchman JL, Weidman JF, Small KV, Sandusky M, Fuhrmann J, Nguyen D, Utterback TR, Saudek DM, Phillips CA, Merrick JM, Tomb JF, Dougherty BA, Bott KF, Hu PC, and Lucier TS. The minimal gene complement of Mycoplasma genitalium. Science 270: 397-403, 1995.
8. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, and Chakravarti A. Patterns of single-nucleotide polymorphisms in candidate genes regulating blood-pressure homeostasis. Nat Genet 22: 239-247, 1999.
9. Harding RM, Fullerton SM, Griffiths RC, Bond J, Cox MJ, Schneider JA, Moulin DS, and Clegg JB. Archaic African and Asian lineages in the genetic ancestry of modern humans. Am J Hum Genet 60: 772-789, 1997.
10. Jeffreys AJ. DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man. Cell 18: 1-10, 1979.
11. Kulkens T, Bolhuis PA, Wolterman RA, Kemp S, te Nijenhuis S, Valentijn LJ, Hensels GW, Jennekens FG, de Visser M, Hoogendijk JE, and Baas F. Deletion of the serine 34 codon from the major peripheral myelin protein PO gene in Charcot-Marie-Tooth disease type 1B. Nat Genet 5: 35-39, 1993.
12. Lai E, Riley J, Purvis I, and Roses A. A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Genomics 54: 31-38, 1998.
13. Lander ES. The new genomics: global views of biology. Science 274: 536-539, 1996.
14. Mushegian AR and Koonin EV. A minimal gene set for cellular life derived by comparison of complete bacterial genomes. Proc Natl Acad Sci USA 93: 10268-10273, 1996.
15. Nickerson DA, Taylor SL, Weiss KM, Clark AG, Hutchinson RG, Stengard J, Salomaa V, Vartiainen E, Boerwinkle E, and Sing CF. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat Genet 19: 233-240, 1998.
16. Ohnishi Y, Tanaka T, Yamada R, Suematsu K, Minami M, Fuji K, Hoki N, Kodama K, Nagata S, Hayashi T, Kinoshita N, Sato H, Sato H, Kuzuya T, Takeda H, Hori M, and Nakamura Y. Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population. Hum Genet 106: 288-292, 2000.
17. Orita M, Sekiya T, and Hayashi K. DNA sequence polymorphisms in Alu repeats. Genomics 8: 271-278, 1990.
18. Risch N and Merikangas K. The future of genetic studies of complex human diseases. Science 273: 1516-1517, 1996.
19. Sunyaev S, Ramensky V, and Bork P. Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Trends Genet 16: 198-200, 2000.
20. Unoki M, Furuta S, Onouchi Y, Watanabe O, Doi S, Fujiwara H, Miyatake A, Fujita K, Tamari M, and Nakamura Y. Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene. Hum Genet 106: 440-446, 2000.