Demonstration of functional receptors for noradrenaline and adenosine-5′-triphosphate, but not for prostaglandin E2, in HT-29 human colon cancer cell line

Autonomic and Autacoid Pharmacology

Volumn 23, Issue 3, 2003, Pages 193-199

  Nylund, G ^a   Nordgren, S ^a   Delbro, D S ^a,b  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINNAEUS UNIVERSITY   (Sweden)

Author keywords

Adenosine 5 triphosphate; COX 2; Cytosensor; HT 29 human colon cancer cell line; Microphysiometer; Noradrenaline; Prostaglandin E2; Tumour cell metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA ADRENERGIC RECEPTOR; CYCLOOXYGENASE 2; MEMBRANE RECEPTOR; NORADRENALIN; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR;

ACIDIFICATION; ARTICLE; CANCER CELL CULTURE; CELL METABOLISM; CELL STRAIN HT29; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; METHODOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECEPTOR DENSITY;

ADENOSINE TRIPHOSPHATE; CYCLOOXYGENASE 2; DINOPROSTONE; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LIGANDS; MEMBRANE PROTEINS; NOREPINEPHRINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, ADRENERGIC; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PURINERGIC P2;

EID: 0347753347     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1474-8673.2003.00295.x     Document Type: Article

References (37)

1. BISHOP-BAILEY, D., CALATAYUD, S., WARNER, T.D., HLA, T. & MITCHELL, J.A. (2002). Prostaglandins and the regulation of tumor growth. J. Environ. Pathol. Toxicol. Oncol., 21, 93-101.
2. BOUSCAREL, B., MURAT, J.C. & PARIS, H. (1985). Involvement of guanine nucleotide and sodium in regulation of yohimbine and clonidine binding sites in the HT29 human colon adenocarcinoma cell-line. Gen. Pharmacol., 16, 641-644.
3. BOUSCAREL, B., CORTINOVIS, C., CARPENE, C., MURAT, J.C. & PARIS, H. (1985). Alpha 2-adrenoceptors in the HT 29 human colon adenocarcinoma cell line: characterization with [3H]clonidine; effects on cyclic AMP accumulation. Eur. J. Pharmacol., 107, 223-231.
4. CASSANO, G., GASPARRE, G., SUSCA, F., LIPPE, C. & GUANTI, G. (2000). Effect of prostaglandin E(2) on the proliferation, Ca(2+) mobilization and cAMP in HT-29 human colon adenocarcinoma cells. Cancer Lett., 152, 217-222.
5. CHAPPLE, K.S., CARTWRIGHT, E.J., HAWCROFT, G. et al. (2000). Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am. J. Pathol., 156, 545-553.
6. DUNLOP, J., ZHANG, Y., SMITH, D.L. & SCHECHTER L.E. (1998). Characterization of 5-HT1A receptor functional coupling in cells expressing the human 5-HT1A receptor as assessed with the cytosensor microphysiometer. J. Pharmacol. Toxicol. Methods, 40, 47-55.
7. GARAVITO, R.M. & MULICHAK, A.M. (2003). The structure of mammalian cyclooxygenases. Annu. Rev. Biophys. Biomol. Struct., 32, 183-206.
8. GOEL, A., BOLAND, C.R., & CHAUHAN, D.P. (2001). Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett., 172, 111-118.
9. GRONERT, K., COLGAN, S.P. & SERHAN, C.N. (1998). Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. J. Pharmacol. Exp. Ther., 285, 252-261.
10. HAFNER, F. (2000). Cytosensor microphysiometer: technology and recent applications. Biosens. Bioelectron., 15, 149-158.
11. HANIF, R., PITTAS, A., FENG, Y., KOUTSOS, M.I., QIAO, L., STAIANO-COICO, L., SHIFF, S.I. & RIGAS, B.L. (1996). Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol., 52, 237-245.
12. HAWCROFT, G., GARDNER, S.H. & HULL, M.A. (2003). Activation of peroxisome proliferator-activated receptor γ does not explain the anti-proliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells. J. Pharmacol. Exp. Ther., 305, 632-637.
13. HÖPFNER, M., LEMMER, K., JANSEN, A., HANSKI, C., RIECKEN, E.O. GAVISH, M., MANN, B., BUHR, H., GLASSMEIER, G. & SCHERUBL, H. (1998). Expression of functional P2-purinergic receptors in primary cultures of human colorectal carcinoma cells. Biochem. Biophys. Res. Commun., 251, 811-817.
14. HÖPFNER, M., MAASER, K., BARTHEL, B., VON LAMPE, B., HANSKI, C., RIECKEN, E.O., ZEITZ, M. & SCHERUBL, H. (2001). Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate. Int. J. Colorectal Dis., 16, 154-166.
15. HSI, L.C., BAEK, S.J. & ELING, T.E. (2000). Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. Exp. Cell. Res., 256, 563-570.
16. IKEDA, K., KOBAYASHI, S., SUZUKI, M., MIYATA, K., YAMADA, T. & HONDA, K. (1999). Ca2+ mobilization and activation of extracellular acidification by carbachol in acutely dispersed cells from guinea pig detrusor: Fura 2 fluorometry and microphysiometry using the cytosensor. Life Sci., 65, 1569-1577.
17. JONES, S.B., TOEWS, M.L., TURNER, J.T. & BYLUND, D.B. (1987). Alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production. Proc. Natl. Acad. Sci. USA, 84, 1294-1298.
18. KAM, P.C. & SEE, A.U. (2000). Cyclo-oxygenase isoenzymes: physiological and pharmacological role. Anaesthesia, 55, 442-449.
19. KIM, H.D., TSAI, Y.S., FRANKLIN, C.C. & TURNER, J.T. (1988). Characterization of Na+/K+/Cl-cotransport in cultured HT29 human colonic adenocarcinoma cells. Biochim. Biophys. Acta, 946, 397-404.
20. KOBAYASHI, S., IKEDA, K., MIYATA, K., YAMADA, T. & HONDA, K. (2001). A method for measurement of muscarinic receptor-mediated responses in dissociated single colon longitudinal smooth muscle cells. J. Pharmacol. Toxicol. Methods, 45, 199-205.
21. KUNE, G.A., KUNE, S. & WATSON, L.F. (1988). Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res., 48, 4399-4404.
22. LÖNNROTH, C., ANDERSSON, M. & LUNDHOLM, K. (2001). Indomethacin and telomerase activity in tumor growth retardation. Int. J. Oncol., 18, 929-937.
23. LUPULESCU, A., (1996). Prostaglandins, their inhibitors and cancer. Prostaglandins Leukot. Essent. Fatty Acids, 54, 83-94.
24. MARNETT, L.J. & DUBOIS, R.N. (2002). COX-2: a target for colon cancer prevention. Annu. Rev. Pharmacol. Toxicol., 42, 55-80.
25. MARNETT, L.J. & KALGUTKAR, A.S. (1999). Cyclooxygenase 2 inhibitors: discovery, selectivity and the future. Trends Pharmacol. Sci., 20, 465-469.
26. MERRITT, G., ALIPRANDIS, E.T., PRADA, F., RIGAS, B. & KASHFI, K. (2001). The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines. Cancer Lett., 164, 15-23.
27. OWICKI, J.C., BOUSSE, L.J., HAFEMAN, D.G., KIRK, G.L., OLSON, J.D., WADA, H.G. & PARCE, J.W. (1994). The light-addressable potentiometric sensor: principles and biological applications. Annu. Rev. Biophys. Biomol. Struct., 23, 87-113.
28. PAI, R., SOREGHAN, B., SZABO, I.L., PAVELKA, M., BAATAR, D. & TARNAWSKI, A.S. (2002). Prostaglandin E2 trans-activates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat. Med., 8, 289-293.
29. RALEVIC, V. & BURNSTOCK, G. (1998). Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413-492.
30. RAZ, A. (2002). Is inhibition of cyclooxygenase required for the anti-tumorigenic effects of nonsteroidal, anti-inflammatory drugs (NSAIDs)? In vitro versus in vivo results and the relevance for the prevention and treatment of cancer. Biochem. Pharmacol., 63, 343-347.
31. RICHARDS, M., VAN GIERSBERGEN, P., ZIMMERMANN, A., LESUR, B. & HOFLACK, J. (1997). Activation of neurotensin receptors and purinoceptors in human colonic adenocarcinoma cells detected with the microphysiometer. Biochem. Pharmacol., 54, 825-832.
32. ROSCHKE, A.V., STOVER, K., TONON, G., SCHAFFER, A.A. & KIRSCH, I.R. (2002). Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability. Neoplasia, 4, 19-31.
33. SMITH, W.L., DEWITT, D.L. & GARAVITO, R.M. (2000). Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem., 69, 145-182.
34. SUN, L., UMEMURA, S., CHUN, M. & PETTINGER, W.A. (1992). Northern blot and ribonuclease protection study of alpha 2-adrenoceptor subtypes in cultured cell lines. Eur. J. Pharmacol., 226, 367-371.
35. THUN, M.J., NAMBOODIRI, M.M. & HEATH, C.W. (1991). Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med., 325, 1593-1596.
36. WILEY, C. & BEESON, C. (2002). Continuous measurement of glucose utilization in heart myoblasts. Anal. Biochem., 304, 139-146.
37. YAMAUCHI, T., WATANABE, M., KUBOTA, T. et al. (2002). Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer. Dis. Colon Rectum, 45, 98-103.