Translational control of protein synthesis: Implications for understanding changes in skeletal muscle mass

International Journal of Sport Nutrition

Volumn 11, Issue SUPPL., 2001, Pages

  Jefferson, L S ^a   Kimball, S R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRANCHED CHAIN AMINO ACID; LEUCINE; MESSENGER RNA; METHIONINE TRANSFER RNA;

CONFERENCE PAPER; EXERCISE; MUSCLE MASS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; SKELETAL MUSCLE; TRANSLATION INITIATION;

EID: 0347746305     PISSN: 10501606     EISSN: None     Source Type: Journal    
DOI: 10.1123/ijsnem.11.s1.s143     Document Type: Conference Paper

References (24)

1. Orally administered leucine stimulates protein synthesis in skeletal muscle of post-absorptive rats in association with increased eIF 4F formation
2. Leucine supplementation enhances skeletal muscle recovery in rats following exercise
3. Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive pathway
4. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis
5. s6k correlates with increased skeletal muscle mass following resistance exercise
6. Preferential utilization of phosphorylated 40S ribosomal subunits during initiation complex formation
7. Rapid alterations in initiation rate and recruitment of inactive RNA are temporally correlated with S 6 phosphorylation
8. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes
9. S6 phosphorylation and signal transduction
10. Availability of eIF 4E regulates skeletal muscle protein synthesis during recovery from exercise
11. cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells
12. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF- 4E BP1 through a common effector mechanism
13. s6k defines its role in protein synthesis and rapamycin sensitivity
14. Implication of eIF 2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts
15. Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle
16. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF 4E and phosphorylation of ribosomal protein S6
17. Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L 1 adipocytes
18. Translational control of TOP mRNAs
19. Drosophila S6 kinase: A regulator of cell size
20. Bidirectional modulation of insulin action by amino acids
21. eIF 4E activity is regulated at multiple levels
22. Regulation of ribosomal recruitment in eukaryotes
23. Disruption of the p70(S6k)/p85(S6k) gene reveals a small mouse phenotype and a new functional S 6 kinase
24. 2α, and insulin on S 6 phosphorylation and the initiation of protein and DNA synthesis