Effects on Mycobacterium avium replication in normal human macrophages by deferiprone (L1) and other iron chelators: Possible implications on toxicity

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 1, 2002, Pages 45-52

  Douvas, George S ^a   May, Mary H ^a   Kolnagou, Annita ^a   Kontoghiorghes, George J ^a  

^a Postgraduate Research Institute of Science Technology Environment and Medicine Limassol   (Cyprus)

Author keywords

CAS 30652 11 0; Deferiprone; Iron chelators; Mycobacterium avium, replication in macrophages; Ketohydroxypyridines

Indexed keywords

1 ALLYL 2 METHYL 3 HYDROXYPYRID 4 ONE; 1 ETHYL 3 HYDROXY 2 METHYL 4 PYRIDONE; 3 HYDROXY 2 METHYL 1 PROPYL 4 PYRIDONE; APOTRANSFERRIN; CAFFEIC ACID; DEFERIPRONE; IRON; IRON CHELATING AGENT; TRANSFERRIN; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BACTERIAL GROWTH; CELL CULTURE; COLONY FORMING UNIT; HUMAN; IRON BLOOD LEVEL; MACROPHAGE; MYCOBACTERIUM AVIUM; NONHUMAN; THALASSEMIA;

EID: 0036148173     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299855     Document Type: Article

References (59)

1. Macrophages and intracellular parasitism
2. Evidence that vesicles containing living, virulent, Mycobacterium tuberculosis, or Mycobacterium avium in cultured human macrophages are not acidic
3. The action of drugs on intracellular tubercle bacilli
4. Response of cultured macrophages to Mycobacterium tuberculosis with observations on fusion of lysosomes with phagosomes
5. Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium
6. Ultrastructural study of the behavior of macrophages toward parasitic mycobacteria
7. Transferrin and heme-compounds as iron sources for pathogenic bacteria
8. Sur la nutrition minerale du bacille tuberculeux
9. Tuberculostatic activity of normal sera
10. Transferrin, iron and serum lipids enhance or inhibit Mycobacterium avium replication in human macrophages
11. Transferrin-dependent growth inhibition of yeast-phase Histoplasma capsulatum by human serum and lymph
12. Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactived and interferon gamma-activated human monocytes depending upon its degree of iron saturation
13. In vitro effect of iron salts and chelating agents on serum tuberculostasis
14. Antimalarial properties of orally active iron chelators
15. Daphnetin: A novel antimalarial agent with in vitro and in vivo activity
16. Yersinia enterocolitis in iron overload
17. Effects of iron and desferrioxamine on infections with Yersinia enterocolitica
18. Macrophage lipoprotein receptors
19. Modification of very low density lipoproteins leads to macrophage scavenger receptor uptake and cholesteryl ester deposition
20. Hypertriglyceridemic serum, very low density lipoprotein, and iron enhance M. avium replication in human macrophages
21. Absence of triglyceride accumulation in lipoprotein lipase-deficient human monocyte-macrophages incubated with human very low density lipoprotein
22. High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis
23. Mycobacterium avium complex infection in the acquired immunodeficiency syndrome
24. Hypertriglyceridemia in the acquired immunodeficiency syndrome
25. The impact of HIV disease progression on serum lipoproteins
26. Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection
27. Deferiprone for thalassaemia
28. Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs
29. Transfusional iron overload and chelation therapy with deferoxamine and deferiprone(L1)
30. Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one
31. Inhibition by normal serum of Mycobacterium avium multiplication cultured human macrophages
32. Comparison of 15 laboratory and patient derived strains of Mycobacterium avium for ability to infect and multiply in cultured human macrophages
33. Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but it enhances replication of macrophage associated mycobacteria
34. A simple method for counting adherent cells: Application to cultured human monocytes, macrophages and multinucleated giant cells
35. Simple synthesis of the potent iron chelators 1-alkyl-3-hydroxy-2-methylpyrid-4-ones
36. In vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei
37. The study of iron mobilization from transferrin using a-ketohydroxy heteroaromatic chelators
38. Effect of novel 1-alkyl-3-hydroxy-2-methylpyrid-4-one chelators on uptake and release of iron from macrophages
39. Characterization of the inhibition of Mycobacterium avium replication in macrophages by normal human serum
40. The relationship between fatty acid peroxidation and a-tocopherol consumption in isolated normal and transformed hepatocytes
41. Sources and role of iron in lipid peroxidation
42. Uptake and intracellular distribution of iron from tranferrin and chelators in erythroid cells
43. In vitro screening of iron chelators using models of free radical damage
44. Effects of iron chelators and iron overload and Salmonella infection
45. Microbial iron-chelators and their action on Klebsiella infections in the skin of guinea pigs
46. Deferoxamine increases the susceptibility of B thalassemic, iron-over-loaded mice to infection with Listeria monocytogenes
47. The combined effect of iron chelators and classical antimalarials on the in-vitro growth of Plasmodium falciparum
48. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron
49. Iron limitation and the gamma interferon mediated antihistoplasma state of murine macrophages
50. Role of iron in intracellular growth of Trypanosoma cruzi
51. The adverse effect of iron repletion on the course of certain infections
52. Iron and malaria
53. Siderotic cerebral macrophages in acquired immunodeficiency syndrome
54. Simultaneous detection of ferritin and HIV-1 in reactive microglia
55. Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches