Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy

American Journal of Cardiology

Volumn 82, Issue 5 A, 1998, Pages 54K-60K

  Taegtmeyer, Heinrich ^a   King, Linda M ^b   Jones, Barney E ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ANIMAL TISSUE; CALCIUM METABOLISM; CELL METABOLISM; CONFERENCE PAPER; DRUG EFFECT; ENERGY METABOLISM; ENERGY TRANSFER; EXCITATION CONTRACTION COUPLING; GENE EXPRESSION REGULATION; GLYCOLYSIS; HEART FUNCTION; HEART MUSCLE ISCHEMIA; ION TRANSPORT; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0032480276     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(98)00538-4     Document Type: Conference Paper

References (77)

1. Taegtmeyer H., Roberts A.F.C., Rayne A.E.G. Energy metabolism in reperfused rat heart return of function before normalization of ATP content . J Am Coll Cardiol. 6:1985;864-870.
2. Taegtmeyer H., Hems R., Krebs H.A. Utilization of energy providing substrates in the isolated working rat heart. Biochem J. 186:1980;701-711.
3. Hinkle P.C., Kumar M.A., Resetar A., Harris D.L. Mechanistic stoichiometry of mitochondrial oxidative phosphorylation. Biochemistry. 30:1991;3576-3582.
4. Page E., McCallister L. Quantitative electron microscopic description of heart muscle cells. Am J Cardiol. 31:1973;172.
5. Barth E., Stämmler G., Speiser B., Schaper J. Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man. J Mol Cell Cardiol. 24:1992;669-681.
6. Jennings R., Ganote C. Mitochondrial structure and function in myocardial ischemic injury. Circ Res. 38:(suppl I):1976;I80-I91.
7. Ferrari R. The role of mitochondria in ischemic heart disease. J Cardiovasc Pharmacol. 38:(suppl 1):1996;S1-S10.
8. Randle P.J., Garland P.B., Hales C.N., Newsholme E.A. The glucose fatty-acid cycle Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus . Lancet. i:1963;785-789.
9. Awan M.M., Saggerson E.D. Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation. Biochem J. 295:1993;61-66.
10. Lopaschuk G.D., Belke D.D., Gamble J., Itoi T., Schonekess B.O. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1213:1994;263-276.
11. Taegtmeyer H. Energy metabolism of the heart from basic concepts to clinical applications . Curr Prob Cardiol. 19:1994;57-116.
12. Brown G.C. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J. 284:1992;1-13.
13. Racker E. Energy cycles in health and disease. Curr Top Cell Regul. 18:1981;361-375.
14. Baldwin J.E., Krebs H.A. The evolution of metabolic cycles. Nature. 291:1981;381-382.
15. Barry W., Bridge J. Intracellular calcium homeostasis in cardiac myocytes. Circulation. 87:1993;1806-1815.
16. Fabiato A. Calcium induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol. 245:1983;C1-C14.
17. Denton R.M., McCormack J.G. On the role of the calcium transport cycle in the heart and other mammalian mitochondria. FEBS Lett. 119:1980;1-8.
18. McCormack J.G., Halestrap A.P., Denton R.M. Role of calcium ions in reperfusion of mammalian intramitochondrial metabolism. Physiol Rev. 70:1990;391-425.
19. Tennant T., Wiggers C.J. Effect of coronary occlusion on myocardial contraction. Am J Physiol. 112:1935;351-361.
20. Taegtmeyer H. Metabolic responses to cardiac hypoxia increased production of succinate by rabbit papillary muscles . Circ Res. 43:1978;808-815.
21. Cross H., Clarke K., Opie L., Radda G. Lactate-induced depression of post-ischemic ventricular recovery is not related to intracellular pH. (Abstr.) Circulation. 88:1993;I-379.
22. Liu B., Clanachan A.S., Schulz R., Lopaschuk G.D. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res. 79:1996;940-948.
23. Shug A., Shrago E., Bittar N., Folts J., Koke J. Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium. Am J Physiol. 228:1975;689-692.
24. Liu B., Alaoui-Talibi Z., Clanachan A.S., Schulz R., Lopaschuk G.D. Uncoupling of contractile function from mitochondrial TCA cycle activity and MVO2 during reperfusion of ischemic hearts. Am J Physiol. 270:1996;H72-H80.
25. Goodwin G., Ahmad F., Taegtmeyer H. Preferential oxidation of glycogen in isolated working rat heart. J Clin Invest. 97:1996;1409-1416.
26. 2+ release and contractile protein function in intact mouse skeletal muscle. J Physiol (Lond). 498:1997;17-29.
27. Rabitzsch G., Mair J., Lechleitner P., Noll F., Hofmann U., Krause E.G., Dienstl F., Puschendorf B. Immunoenzymometric assay of human glycogen phosphorylase isoenzyme BB in diagnosis of ischemic myocardial injury. Clin Chem. 41:1995;966-978.
28. Doenst T., Guthrie P.H., Chemnitius J.-M., Zech R., Taegtmeyer H. Fasting lactate, and insulin improve ischemia tolerance a comparison with ischemic preconditioning . Am J Physiol. 270:1996;H1607-H1615.
29. Young L.H., Renfu Y., Russell R., Hu X., Caplan M., Ren J., Shulman G.I., Sinusas A.J. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation. 95:1997;415-422.
30. McNulty P.H., Sinusas A.J., Shi C.Q.X., Dione D., Young L.H., Cline G.C., Shulman G.I. Glucose metabolism distal to a critical coronary stenosis canine model of low-flow myocardial ischemia. J Clin Invest. 98:1996;62-69.
31. King L.M., Boucher F., Opie L.H. Coronary flow and glucose delivery as determinants of contracture in the ischemic myocardium. J Mol Cell Cardiol. 27:1995;701-720.
32. Bolukoglu H., Goodwin G.W., Guthrie P.H., Carmical S.G., Chen T.M., Taegtmeyer H. Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. Am J Physiol. 270:1996;H817-H826.
33. 3. N Engl J Med. 314:1986;884-888.
34. Depré C., Vanoverschelde J.L., Melin J.A., Borgers M., Bol A., Ausma J., Dion R., Wijns W. Structural and metabolic correlates of the reversibility of chronic left ventricular ischemic dysfunction in humans. Am J Physiol. 268:1995;H1265-H1275.
35. McDonald T., MacLeod D. Metabolism and the electrical activity of ventricular muscle. J Physiol (Lond). 229:1973;559-582.
36. 87Rb NMR spectroscopic study . Magn Reson Med. 34:1995;673-685.
37. 2+ transport. Circ Res. 77:1995;88-97.
38. + channels in isolated guinea pig cardiac myocytes. Science. 238:1987;67-69.
39. Sun D., Nguyen N., Delgrado T.R., Schwaiger M., Brosius F.C.I. Ischemia induces translocation of the insulin-responsive glucose transporter GLUT 4 to the plasma membrane of cardiac myocytes. Circulation. 89:1994;793-798.
40. Gradinak S., Coleman G.M., Taegtmeyer H., Sweeney M.S., Frazier O.H. Improved cardiac function with glucose-insulin-potassium after coronary bypass surgery. Ann Thorac Surg. 48:1989;484-489.
41. Eberli F.R., Weinberg E.O., Grice W.N., Horowitz G.L., Apstein C.S. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circ Res. 68:1991;466-481.
42. Mallet R.T., Hartman D.A., Bu̧nger R. Glucose requirement for postischemic recovery of perfused working heart. Eur J Biochem. 188:1990;481-493.
43. Schaefer S., Prussel E., Carr L.J. Requirement of glycolytic substrate for metabolic recovery during moderate low flow ischemia. J Mol Cell Cardiol. 27:1995;2167-2176.
44. Gevers W. Generation of protons by metabolic processes in heart cells. J Mol Cell Cardiol. 9:1977;867-874.
45. Dennis S., Gevers W., Opie L. Protons in ischemia where do they come from, where do they go to? J Mol Cell Cardiol. 23:1991;1077-1086.
46. Gaskill W. On the tonicity of the heart and blood vessels. J Physiol (Lond). 3:1880;48-75.
47. 2+ release in rat myocardium. J Gen Physiol. 90:1987;145-165.
48. Orchard C., Kentish J. Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol. 258:1990;C967-C981.
49. Cross H., Clarke K., Opie L., Radda G. Is lactate-induced myocardial ischaemic injury mediated by decreased pH or increased intracellular lactate? J Mol Cell Cardiol. 27:1995;1369-1381.
50. + exchange . Am J Physiol. 255:1988;H608-H615.
51. Murphy E., Perlman M., London R.E., Steenbergen C. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ Res. 68:1991;1250-1258.
52. + exchange inhibitor and its effects in cardiac ischaemia. Br J Pharmacol. 109:1993;563-568.
53. Safer B., Williamson J. Mitochondrial-cytosolic interactions in perfused rat heart role of coupled transamination in repletion of citric acid cycle intermediates . J Biol Chem. 248:1973;2570-2579.
54. Lewandowski E.D., White L.T. Pyruvate dehydrogense influences postischemic heart function. Circulation. 91:1995;2071-2079.
55. Lopaschuk G., Warmbolt R., Barr R. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Exp Ther. 264:1993;135-144.
56. McVeigh J.J., Lopaschuk G.D. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol. 259:1990;H1079-H1085.
57. Broderick T.L., Quinney H.A., Lopaschuk G.D. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J Biol Chem. 267:1992;3758-3763.
58. Lopaschuk G.D., Wall S.R., Olley P.M., Davies N.J. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 63:1988;1036-1043.
59. McCormack J.G., Barr R.L., Wolff A.A., Lopaschuk G.D. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation. 93:1996;135-142.
60. Fantini E., Demaison L., Sentex E., Grynberg A., Athias P. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol. 26:1994;949-958.
61. Goodwin G.W., Taegtmeyer H. Metabolic recovery of the isolated working rat heart after brief global ischemia. Am J Physiol. 267:1994;H462-H470.
62. Taegtmeyer H., Goodwin G.W., Doenst T., Frazier O.H. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol. 80:(suppl):1997;3A-10A.
63. Lagerstrom C.F., Walker W.E., Taegtmeyer H. Failure of glycogen depletion to improve left ventricular function of the rabbit heart after hypothermic ischemic arrest. Circ Res. 63:1988;81-86.
64. King L., Opie L. Is preconditioning linked to glycogen depletion? (Abstr.) J Mol Cell Cardiol. 27:1995;A149.
65. Schneider C.A., Nguyêñ V.T.B., Taegtmeyer H. Feeding and fasting determine postischemic glucose utilization in isolated working rat hearts. Am J Physiol. 260:1991;H542-H548.
66. Kentish J. The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rabbit ventricle. J Physiol. 370:1986;585-604.
67. Jennings R.B., Hawkins H.K., Lowe J.E., Hill M.L., Klotman S., Reimer K.A. Relation between high energy phosphate and lethal injury in myocardial ischemia. Am J Pathol. 92:1978;187-214.
68. Ely S., Berne R. Protective effects of adenosine in myocardial ischemia. Circulation. 85:1992;893-904.
69. Lee J., Allen D. Changes in intracellular free calcium concentration during long exposures to simulated ischemia in isolated mammalian ventricular muscle. Circ Res. 71:1992;58-69.
70. 2+ overload in reperfused ischemic myocardium. Annu Rev Physiol. 52:1990;543-559.
71. Fleckenstein A., Jahnke J., Doring H., Leder O. Key role of Ca in the production of noncoronarogenic myocardial necroses. Recent Adv Stud Cardiac Struct. 6:1975;21-32.
72. Katz A., Reuter H. Cellular calcium and cell death. Am J Cardiol. 44:1979;188-190.
73. Lehninger A. Mitochondria and calcium ion transport. (Abstr.) Biochem J. 119:1970;129-138.
74. 2+ overload . Eur J Biochem. 178:1988;488-501.
75. Carafoli E., Bing R. Myocardial failure. (Abstr.) J Appl Cardiol. 3:1988;3-18.
76. Nayler W., Ferrari R., Williams A. Protective effect of pretreatment with verapamil, nifedipine, and propranolol on mitochondrial function in the ischemic and reperfused myocardium. Am J Cardiol. 46:1980;242-248.
77. Ferrari R., Visioli O. Protective effects of calcium antagonsists against ischemia and reperfusion damage. Drugs. 42:1991;14-27.