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Volumn 9, Issue 4, 2003, Pages 359-374

Pharmacology of Acamprosate: An Overview

Author keywords

Acamprosate; Alcoholism; Anticraving drugs; Drug addiction; Relapse

Indexed keywords

ACAMPROSATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0347418926     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.2003.tb00260.x     Document Type: Review
Times cited : (34)

References (69)
  • 2
    • 0031813519 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate: Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex
    • Al-Qatari M, Bouchenafa O, Littleton J. Mechanism of action of acamprosate: Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 1998;22:810-814.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 810-814
    • Al-Qatari, M.1    Bouchenafa, O.2    Littleton, J.3
  • 3
    • 0034820542 scopus 로고    scopus 로고
    • Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain
    • Al-Qatari M, Khan S, Harris B, Littleton J. Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin Exp Res 2001;25:1276-1283.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 1276-1283
    • Al-Qatari, M.1    Khan, S.2    Harris, B.3    Littleton, J.4
  • 4
    • 0002901575 scopus 로고    scopus 로고
    • Acamprosate inhibits the up-regulation of calcium channels in rat brain associated with development of ethanol dependence
    • Al-Qatari M, Littleton J. Acamprosate inhibits the up-regulation of calcium channels in rat brain associated with development of ethanol dependence. Alcohol Clin Exp Res 1996;20:92A.
    • (1996) Alcohol Clin Exp Res , vol.20
    • Al-Qatari, M.1    Littleton, J.2
  • 5
    • 0027174290 scopus 로고
    • Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route
    • Anderberg EK, Lindmark T, Artursson P. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharmac Res 1993;10:857-864.
    • (1993) Pharmac Res , vol.10 , pp. 857-864
    • Anderberg, E.K.1    Lindmark, T.2    Artursson, P.3
  • 7
    • 0030925837 scopus 로고    scopus 로고
    • Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens
    • Blaha CD, Yang CR, Floresco SB, Barr AM, Phillips A. Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens. Eur J Neurosci 1997;5:902-911.
    • (1997) Eur J Neurosci , vol.5 , pp. 902-911
    • Blaha, C.D.1    Yang, C.R.2    Floresco, S.B.3    Barr, A.M.4    Phillips, A.5
  • 8
    • 0021721951 scopus 로고
    • A homotaurine derivate reduces the voluntary intake of ethanol by rats. Are cerebral GABA receptors involved?
    • Boismare F, Daoust M, Moore ND, et al. A homotaurine derivate reduces the voluntary intake of ethanol by rats. Are cerebral GABA receptors involved? Pharmacol Biochem Behav 1984;21:787-789.
    • (1984) Pharmacol Biochem Behav , vol.21 , pp. 787-789
    • Boismare, F.1    Daoust, M.2    Moore, N.D.3
  • 9
    • 0031033681 scopus 로고    scopus 로고
    • Release of dopamine in the nucleus accumbens caused by stimulation of the subiculum in freely moving rats
    • Brudzynski SM, Gibson CJ. Release of dopamine in the nucleus accumbens caused by stimulation of the subiculum in freely moving rats. Brain Res Bull 1997;42:303-308.
    • (1997) Brain Res Bull , vol.42 , pp. 303-308
    • Brudzynski, S.M.1    Gibson, C.J.2
  • 10
    • 24244454172 scopus 로고    scopus 로고
    • Effect of non-ionic surfactants (polysorbate 80) on the intestinal absorption of acamprosate in the rat
    • Cano-Cebrián MJ, Zornoza-Sabina T, Guerri C, Granero L, Polache A. Effect of non-ionic surfactants (polysorbate 80) on the intestinal absorption of acamprosate in the rat. Alcohol Alcohol 2001;36:505.
    • (2001) Alcohol Alcohol , vol.36 , pp. 505
    • Cano-Cebrián, M.J.1    Zornoza-Sabina, T.2    Guerri, C.3    Granero, L.4    Polache, A.5
  • 11
    • 0037292255 scopus 로고    scopus 로고
    • Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: An in vivo microdialysis study
    • Cano-Cebrián MJ, Zornoza-Sabina T, Guerri C, Polache A, Granero L. Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study. Naunyn-Schmiedeberg's Arch Pharmacol 2003;367:119-125.
    • (2003) Naunyn-Schmiedeberg's Arch Pharmacol , vol.367 , pp. 119-125
    • Cano-Cebrián, M.J.1    Zornoza-Sabina, T.2    Guerri, C.3    Polache, A.4    Granero, L.5
  • 12
    • 0023909128 scopus 로고
    • Physicochemical, pharmacological and pharmacokinetic study of a new gabaergic compound, calcium acetylhomotaurinate
    • Chabenat C, Chretien P, Daoust M, et al. Physicochemical, pharmacological and pharmacokinetic study of a new gabaergic compound, calcium acetylhomotaurinate. Meth Find Exp Clin Pharmacol 1988;10:311-317.
    • (1988) Meth Find Exp Clin Pharmacol , vol.10 , pp. 311-317
    • Chabenat, C.1    Chretien, P.2    Daoust, M.3
  • 13
    • 0032953635 scopus 로고    scopus 로고
    • Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour
    • Cole JC, Littleton J, Little HJ. Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour. Psychopharmacology 1999;142:270-279.
    • (1999) Psychopharmacology , vol.142 , pp. 270-279
    • Cole, J.C.1    Littleton, J.2    Little, H.J.3
  • 14
    • 0033958458 scopus 로고    scopus 로고
    • Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze
    • Cole JC, Littleton J, Little HJ. Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology 2000;147:403-411.
    • (2000) Psychopharmacology , vol.147 , pp. 403-411
    • Cole, J.C.1    Littleton, J.2    Little, H.J.3
  • 15
    • 0035106434 scopus 로고    scopus 로고
    • Effects of acamprosate on ethanol-seeking and self-administration in the rat
    • Czachowski CL, Legg BH, Samson HH. Effects of acamprosate on ethanol-seeking and self-administration in the rat. Alcohol Clin Exp Res 2001;25:344-350.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 344-350
    • Czachowski, C.L.1    Legg, B.H.2    Samson, H.H.3
  • 16
    • 0032550745 scopus 로고    scopus 로고
    • Central effects of acamprosate: Part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats
    • Dahchour A, De Witte P, Bolo N, et al. Central effects of acamprosate: Part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats. Psychiatry Res Neuroimaging 1998;82:107-114.
    • (1998) Psychiatry Res Neuroimaging , vol.82 , pp. 107-114
    • Dahchour, A.1    De Witte, P.2    Bolo, N.3
  • 17
    • 0032969446 scopus 로고    scopus 로고
    • Acamprosate decreases the hypermotility during repeated ethanol withdrawal
    • Dahchour A, De Witte P. Acamprosate decreases the hypermotility during repeated ethanol withdrawal. Alcohol 1999;18:77-81.
    • (1999) Alcohol , vol.18 , pp. 77-81
    • Dahchour, A.1    De Witte, P.2
  • 18
    • 0037345627 scopus 로고    scopus 로고
    • Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods
    • Dahchour A, De Witte P. Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods. Alcohol Clin Exp Res 2003;27:465-470.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 465-470
    • Dahchour, A.1    De Witte, P.2
  • 19
    • 0026612522 scopus 로고
    • Acamprosate modulates synaptosomal GABA transmission in chronically alcoholised rats
    • Daoust M, Legrand E, Gewiss M, et al. Acamprosate modulates synaptosomal GABA transmission in chronically alcoholised rats. Pharmacol Biochem Behav 1992;41:669-674.
    • (1992) Pharmacol Biochem Behav , vol.41 , pp. 669-674
    • Daoust, M.1    Legrand, E.2    Gewiss, M.3
  • 20
    • 24244464782 scopus 로고
    • Calcium bis acetyl homotaurine increases the number of GABA uptake sites in alcohol prefering rat hippocampus
    • Daoust M, Prevost M, Saligaut C, et al. Calcium bis acetyl homotaurine increases the number of GABA uptake sites in alcohol prefering rat hippocampus. Alcohol Alcohol 1986;21:A31.
    • (1986) Alcohol Alcohol , vol.21
    • Daoust, M.1    Prevost, M.2    Saligaut, C.3
  • 21
    • 0004001952 scopus 로고
    • Rat pharmacokinetic profile of acamprosate in plasma, brain and CSF
    • Durbin P, Belleville M. Rat pharmacokinetic profile of acamprosate in plasma, brain and CSF. Alcohol Alcohol 1995;30:548.
    • (1995) Alcohol Alcohol , vol.30 , pp. 548
    • Durbin, P.1    Belleville, M.2
  • 22
    • 0031688235 scopus 로고    scopus 로고
    • Chronic ethanol consumption: From neuroadaptation to neurodegeneration
    • Fadda F, Rossetti ZL. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Prog Neurobiol 1998;56:385-431.
    • (1998) Prog Neurobiol , vol.56 , pp. 385-431
    • Fadda, F.1    Rossetti, Z.L.2
  • 23
    • 0035400083 scopus 로고    scopus 로고
    • Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    • Floresco SB, Todd CL, Grace AA. Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons. J Neurosci 2001;21:4915-4922.
    • (2001) J Neurosci , vol.21 , pp. 4915-4922
    • Floresco, S.B.1    Todd, C.L.2    Grace, A.A.3
  • 24
    • 0346154605 scopus 로고
    • Gastrointestinal absorption-Biological considerations
    • Gibaldi M, ed. Philadelphia: Lea and Febiger
    • Gibaldi M. Gastrointestinal absorption-Biological considerations. In: Gibaldi M, ed. Biopharmaceutics and Clinical Pharmacokinetics. Philadelphia: Lea and Febiger, 1991:25-39.
    • (1991) Biopharmaceutics and Clinical Pharmacokinetics , pp. 25-39
    • Gibaldi, M.1
  • 25
    • 0024403638 scopus 로고
    • Reinforcing and discriminative stimulus effects of calcium-acetyl homotaurine in animals
    • Grant KA, Woolverton D. Reinforcing and discriminative stimulus effects of calcium-acetyl homotaurine in animals. Pharmacol Biochem Behav 1989;32:607-611.
    • (1989) Pharmacol Biochem Behav , vol.32 , pp. 607-611
    • Grant, K.A.1    Woolverton, D.2
  • 26
    • 12244265522 scopus 로고    scopus 로고
    • Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors
    • Harris BR, Prendergast MA, Gibson A et al. Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcohol Clin Exp Res 2002;26:1779-1793.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1779-1793
    • Harris, B.R.1    Prendergast, M.A.2    Gibson, A.3
  • 27
    • 0031958251 scopus 로고    scopus 로고
    • Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of polyethylene glycol and D-peptides
    • He YL, Murby S, Warhurst G, et al. Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of polyethylene glycol and D-peptides. J Pharm Sci 1998;87:626-633.
    • (1998) J Pharm Sci , vol.87 , pp. 626-633
    • He, Y.L.1    Murby, S.2    Warhurst, G.3
  • 28
    • 0042887031 scopus 로고    scopus 로고
    • Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats
    • Heyser CJ, Moc K, Koob GF. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacology 2003;28:1463-1471.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1463-1471
    • Heyser, C.J.1    Moc, K.2    Koob, G.F.3
  • 29
    • 0032007883 scopus 로고    scopus 로고
    • Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats
    • Heyser CJ, Schulteis G, Durbin P, Koob GF. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 1998;18:125-133.
    • (1998) Neuropsychopharmacology , vol.18 , pp. 125-133
    • Heyser, C.J.1    Schulteis, G.2    Durbin, P.3    Koob, G.F.4
  • 30
    • 0343683410 scopus 로고    scopus 로고
    • Time course of acamprosate action on operant self-administration after ethanol deprivation
    • Hölter SM, Landgraf R, Zieglgansberger W, Spanagel R. Time course of acamprosate action on operant self-administration after ethanol deprivation. Alcohol Clin Exp Res 1997;21:862-868.
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 862-868
    • Hölter, S.M.1    Landgraf, R.2    Zieglgansberger, W.3    Spanagel, R.4
  • 31
    • 0034071789 scopus 로고    scopus 로고
    • Neuropharmacological treatments for alcoholism: Scientific basis and clinical findings
    • Johnson BA, Ait-Daoud N. Neuropharmacological treatments for alcoholism: Scientific basis and clinical findings. Psychopharmacology 2000;149:327-344.
    • (2000) Psychopharmacology , vol.149 , pp. 327-344
    • Johnson, B.A.1    Ait-Daoud, N.2
  • 32
    • 0038341150 scopus 로고    scopus 로고
    • Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjects
    • Johnson BA, O'Malley SS, Ciraulo DA, et al. Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjects. J Clin Psychopharmacol 2003;23:281-293.
    • (2003) J Clin Psychopharmacol , vol.23 , pp. 281-293
    • Johnson, B.A.1    O'Malley, S.S.2    Ciraulo, D.A.3
  • 33
    • 0038012560 scopus 로고    scopus 로고
    • Acamprosate does not induce a conditioned place preference and reveals no state-dependent effects in this paradigm
    • Kratzer U, Schmidt WJ. Acamprosate does not induce a conditioned place preference and reveals no state-dependent effects in this paradigm. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:653-656.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 653-656
    • Kratzer, U.1    Schmidt, W.J.2
  • 34
    • 0036016259 scopus 로고    scopus 로고
    • Neurobiology of relapse to alcohol in rats
    • Lê AD, Shaham Y. Neurobiology of relapse to alcohol in rats. Pharmacol Ther 2002;94:137-156.
    • (2002) Pharmacol Ther , vol.94 , pp. 137-156
    • Lê, A.D.1    Shaham, Y.2
  • 35
    • 0034652084 scopus 로고    scopus 로고
    • Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area
    • Legault M, Rompré PP, Wise R. Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area. J Neurosci 2000;20:1635-1642
    • (2000) J Neurosci , vol.20 , pp. 1635-1642
    • Legault, M.1    Rompré, P.P.2    Wise, R.3
  • 36
    • 0033558921 scopus 로고    scopus 로고
    • Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens
    • Legault M, Wise R. Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens. Synapse 1999;31:241-249
    • (1999) Synapse , vol.31 , pp. 241-249
    • Legault, M.1    Wise, R.2
  • 37
    • 0023216221 scopus 로고
    • Dose-dependent supression of the high alcohol intake of chronically intoxicated rats by Ca-acetylhomotaurinate
    • LeMagnen J, Tran G, Durlach J, Martin C. Dose-dependent supression of the high alcohol intake of chronically intoxicated rats by Ca-acetylhomotaurinate. Alcohol 1987;4:97-102.
    • (1987) Alcohol , vol.4 , pp. 97-102
    • LeMagnen, J.1    Tran, G.2    Durlach, J.3    Martin, C.4
  • 38
    • 0021804618 scopus 로고
    • Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics
    • Lhuintre JP, Daoust M, Moore ND, et al. Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics. Lancet 1985;1(8436):1014-1016.
    • (1985) Lancet , vol.1 , Issue.8436 , pp. 1014-1016
    • Lhuintre, J.P.1    Daoust, M.2    Moore, N.D.3
  • 39
    • 0025685344 scopus 로고
    • Acamprosate appears to decrease alcohol intake in weaned alcoholics
    • Lhuintre JP, Moore ND, Tran G, et al. Acamprosate appears to decrease alcohol intake in weaned alcoholics. Alcohol Alcohol 1990;25:613-622.
    • (1990) Alcohol Alcohol , vol.25 , pp. 613-622
    • Lhuintre, J.P.1    Moore, N.D.2    Tran, G.3
  • 40
    • 0031885344 scopus 로고    scopus 로고
    • Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells
    • Lindmark T, Kimura Y, Artursson P. Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. J Pharmacol Exp Ther 1998;284:362-369
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 362-369
    • Lindmark, T.1    Kimura, Y.2    Artursson, P.3
  • 41
    • 0029129027 scopus 로고
    • Acamprosate in alcohol dependence: How does it work?
    • Littleton J. Acamprosate in alcohol dependence: How does it work? Addiction 1995;90:1179-1188.
    • (1995) Addiction , vol.90 , pp. 1179-1188
    • Littleton, J.1
  • 42
    • 0037275407 scopus 로고    scopus 로고
    • The anti-relapse compound acamprosate inhibits the development of a conditioned preference to ethanol and cocaine but not morphine
    • McGeehan AJ, Olive MF. The anti-relapse compound acamprosate inhibits the development of a conditioned preference to ethanol and cocaine but not morphine. Br J Pharmacol 2003;138:9-12.
    • (2003) Br J Pharmacol , vol.138 , pp. 9-12
    • McGeehan, A.J.1    Olive, M.F.2
  • 44
    • 0034816006 scopus 로고    scopus 로고
    • Treatment of alcohol-dependent outpatients with acamprosate: A clinical review
    • Mason BJ. Treatment of alcohol-dependent outpatients with acamprosate: a clinical review. J Clin Psychiatry 2001;62(Suppl 20):42-48.
    • (2001) J Clin Psychiatry , vol.62 , Issue.SUPPL. 20 , pp. 42-48
    • Mason, B.J.1
  • 45
    • 0036791872 scopus 로고    scopus 로고
    • A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone
    • Mason BJ, Goodman AM, Dixon RM, et al. A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone. Neuropsychopharmacology 2002;27:596-606.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 596-606
    • Mason, B.J.1    Goodman, A.M.2    Dixon, R.M.3
  • 46
    • 0036797201 scopus 로고    scopus 로고
    • Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    • Mayer S, Harris BR, Gibson A, et al. Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcohol Clin Exp Res 2002;26:1468-1478.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1468-1478
    • Mayer, S.1    Harris, B.R.2    Gibson, A.3
  • 47
    • 0031868767 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate: Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain
    • Naassila M, Hammoumi S, Legrand E, Durbin P, Daoust M. Mechanism of action of acamprosate: Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 1998;22:802-809.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 802-809
    • Naassila, M.1    Hammoumi, S.2    Legrand, E.3    Durbin, P.4    Daoust, M.5
  • 48
    • 0037083817 scopus 로고    scopus 로고
    • Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release
    • Olive MF, Nannini MA, Ou CJ, Koenig HN, Hodge CW. Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release. Eur J Pharmacol 2002;437:55-61.
    • (2002) Eur J Pharmacol , vol.437 , pp. 55-61
    • Olive, M.F.1    Nannini, M.A.2    Ou, C.J.3    Koenig, H.N.4    Hodge, C.W.5
  • 49
    • 18744422986 scopus 로고    scopus 로고
    • The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal
    • Putzke J, Spanagel R, Tolle TR, Zieglgansberger W. The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. Eur J Pharmacol 1996;317:39-48.
    • (1996) Eur J Pharmacol , vol.317 , pp. 39-48
    • Putzke, J.1    Spanagel, R.2    Tolle, T.R.3    Zieglgansberger, W.4
  • 50
    • 0036399161 scopus 로고    scopus 로고
    • Acamprosate reduces context-dependent ethanol effects
    • Quertemont E, Brabant C, De Witte P. Acamprosate reduces context-dependent ethanol effects. Psychopharmacology 2002;164:10-18.
    • (2002) Psychopharmacology , vol.164 , pp. 10-18
    • Quertemont, E.1    Brabant, C.2    De Witte, P.3
  • 51
    • 0035001893 scopus 로고    scopus 로고
    • The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
    • Rammes G, Mahal B, Putzke J, et al. The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 2001;40:749-760.
    • (2001) Neuropharmacology , vol.40 , pp. 749-760
    • Rammes, G.1    Mahal, B.2    Putzke, J.3
  • 52
    • 0028819491 scopus 로고
    • Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist
    • Ripley TL, Little HJ. Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther 1995;272:112-118.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 112-118
    • Ripley, T.L.1    Little, H.J.2
  • 53
    • 0029119866 scopus 로고
    • Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum
    • Rossetti ZL, Carboni S. Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum. Eur J Pharmacol 1995;283:177-183.
    • (1995) Eur J Pharmacol , vol.283 , pp. 177-183
    • Rossetti, Z.L.1    Carboni, S.2
  • 54
    • 0029737567 scopus 로고    scopus 로고
    • Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence
    • Saas H, Soyka M, Zieglgansberger W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 1996;53:673-680.
    • (1996) Arch Gen Psychiatry , vol.53 , pp. 673-680
    • Saas, H.1    Soyka, M.2    Zieglgansberger, W.3
  • 56
    • 0036364469 scopus 로고    scopus 로고
    • Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholics. Results from a non-blind, multicenter study
    • Soyka M, Preuss U, Schuetz C. Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholics. Results from a non-blind, multicenter study. Drugs Res Dev 2002;3:1-12.
    • (2002) Drugs Res Dev , vol.3 , pp. 1-12
    • Soyka, M.1    Preuss, U.2    Schuetz, C.3
  • 57
    • 0034114914 scopus 로고    scopus 로고
    • Pharmacological validation of a new animal model of alcoholism
    • Spanagel R, Hölter SM. Pharmacological validation of a new animal model of alcoholism. J Neural Transm 2000;107:669-680.
    • (2000) J Neural Transm , vol.107 , pp. 669-680
    • Spanagel, R.1    Hölter, S.M.2
  • 58
    • 0342281459 scopus 로고    scopus 로고
    • Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat
    • Spanagel R, Hölter SM, Allingham K, Landgraf R. Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 1996;305:39-44.
    • (1996) Eur J Pharmacol , vol.305 , pp. 39-44
    • Spanagel, R.1    Hölter, S.M.2    Allingham, K.3    Landgraf, R.4
  • 59
    • 17044458222 scopus 로고    scopus 로고
    • Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat
    • Spanagel R, Zieglgansberger W, Hundt W. Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat. Eur J Pharmacol 1996;305:51-56.
    • (1996) Eur J Pharmacol , vol.305 , pp. 51-56
    • Spanagel, R.1    Zieglgansberger, W.2    Hundt, W.3
  • 60
    • 0031081578 scopus 로고    scopus 로고
    • Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes
    • Spanagel R, Zieglgansberger W. Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes. Trends Pharmacol Sci 1997;18:54-59.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 54-59
    • Spanagel, R.1    Zieglgansberger, W.2
  • 61
    • 0035028059 scopus 로고    scopus 로고
    • Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption
    • Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP. Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. Alcohol 2001;23:109-116.
    • (2001) Alcohol , vol.23 , pp. 109-116
    • Stromberg, M.F.1    Mackler, S.A.2    Volpicelli, J.R.3    O'Brien, C.P.4
  • 63
    • 0036581045 scopus 로고    scopus 로고
    • Behavioral neurobiology of alcohol addiction: Recent advances and challenges
    • Weiss F, Porrino LJ. Behavioral neurobiology of alcohol addiction: Recent advances and challenges. J Neurosci 2002;22:3332-3337.
    • (2002) J Neurosci , vol.22 , pp. 3332-3337
    • Weiss, F.1    Porrino, L.J.2
  • 64
    • 0029994413 scopus 로고    scopus 로고
    • Comparison of acamprosate and placebo in long-term treatment of alcohol dependence
    • Whitworth AB. Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet 1996;347:1438-1442.
    • (1996) Lancet , vol.347 , pp. 1438-1442
    • Whitworth, A.B.1
  • 65
    • 0031005968 scopus 로고    scopus 로고
    • Acamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification
    • Wilde MI, Wagstaff AJ. Acamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification. Drugs 1997;56:1038-53
    • (1997) Drugs , vol.56 , pp. 1038-1053
    • Wilde, M.I.1    Wagstaff, A.J.2
  • 66
    • 0027402518 scopus 로고
    • Acamprosate decreases postsynaptic potentials in the rat neocortex: Possible role of excitatory amino acid receptors
    • Zeise ML, Kasparov S, Capogna M, Zieglgansberger W. Acamprosate decreases postsynaptic potentials in the rat neocortex: Possible role of excitatory amino acid receptors. Eur J Pharmacol 1993;23:47-52.
    • (1993) Eur J Pharmacol , vol.23 , pp. 47-52
    • Zeise, M.L.1    Kasparov, S.2    Capogna, M.3    Zieglgansberger, W.4
  • 69


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