Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: A microdialysis study

Brain Research

Volumn 884, Issue 1-2, 2000, Pages 77-86

  Scism, Jamie L ^a   Powers, Karen M ^b   Artru, Alan A ^b   Lewis, Lydia ^c   Shen, Danny D ^c  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Blood brain barrier; Brain parenchyma; Efflux transport; Organic anion transporter; Valproic acid

Indexed keywords

PROBENECID; TRITIUM; TRYPAN BLUE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG ELIMINATION; ELECTROENCEPHALOGRAM; EXTRACELLULAR FLUID; GAS CHROMATOGRAPHY; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MASS SPECTROMETRY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN; CARRIER PROTEINS; CELL MEMBRANE; DRUG INTERACTIONS; EPILEPSY; EXTRACELLULAR SPACE; INTRACELLULAR FLUID; ION PUMPS; MALE; MICRODIALYSIS; NEUROGLIA; NEURONS; PROBENECID; RABBITS; VALPROIC ACID;

EID: 0034711537     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02893-6     Document Type: Article

References (34)

1. Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system
2. Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter
3. Effects of valproate in a model nervous system (buccal ganglia of Helix pomatia): I. Antiepileptic actions
4. Interaction between probenecid and two lipid-soluble barbiturates in the rat
5. Blood-brain barrier transport of valproic acid
6. Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain
7. Valproic acid: mechanisms of action
8. Assessment of valproic acid serum-cerebrospinal fluid transport by microdialysis
9. An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity
10. In vivo uptake of valproic acid into brain
11. Physiologically based pharmacokinetics of valproic acid in rabbits
12. Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration
13. Diurnal oscillations of CSF valproate in monkey
14. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
15. Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment
16. Penetration of valproate and its active metabolites into cerebrospinal fluid of children with epilepsy
17. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C
18. Simultaneous and continuous measurement of free concentration of valproate in blood and extracellular space of rat cerebral cortex
19. Mechanism of valproic acid uptake by isolated rat brain microvessels
20. Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse
21. Transport of valproate and its effects on GABA uptake in astroglial primary culture
22. Quantitative approaches to in vivo brain microdialysis
23. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
24. Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques
25. Effects of probenecid on brain-cerebrospinal fluid-blood distribution kinetics of E-Delta 2-valproic acid in rabbits
26. Capillary gas chromatographic assay for valproic acid and its 2-desaturated metabolite in brain and plasma
27. Comparative pharmacodynamics and brain distribution of E-delta 2-valproate and valproate in rats
28. Low and variable presence of valproic acid in human brain
29. Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 h of therapy
30. Effect of probenecid on breathing movements and cerebral clearance of prostaglandin E2 in fetal sheep
31. Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide
32. The extracellular concentration of the anti-epileptic drug valproate in the rat brain as determined with microdialysis and an automated HPLC procedure