Determination of downstream targets of FGF signalling using gene trap and cDNA subtractive approaches

Experimental Cell Research

Volumn 292, Issue 1, 2004, Pages 101-114

  Tateossian, Hilda ^a   Powles, Nicola ^a   Dickinson, Robin ^b   Ficker, Michael ^a   Maconochie, Mark ^a,c  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

cDNA subtraction; ES cells; FGF signalling; Gene trap

Indexed keywords

CHAPERONE; COLLAPSIN MEDIATOR RESPONSE PROTEIN; COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR; PROTEIN; PROTEIN MRJ; PROTEIN NAC1; RIBOPHORIN I; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPRESSOR GENE; SIGNAL TRANSDUCTION; STEM CELL;

MAMMALIA;

EID: 0347356276     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2003.08.008     Document Type: Article

References (42)

1. Vendrell V., Carnicero E., Giraldez F., Alonso M.T., Schimmang T. Induction of inner ear fate by FGF3. Development. 127:2000;2011-2019.
2. Represa J., Leon Y., Miner C., Giraldez F. The int-2 proto-oncogene is responsible for inner ear induction. Nature. 353:1991;561-563.
3. Sekine K., Ohuchi H., Fujiwara M., Yamasaki M., Yoshizawa T., Sato T., Yagishita N., Matsui D., Koga Y., Itoh N., Kato S. Fgf10 is essential for limb and lung formation. Nat. Genet. 21:1999;138-141.
4. Min H., Danilenko D., Scully S., Bolon B., Ring B., Tarpley J., DeRose M., Simonet W. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12:1998;3156-3161.
5. Lewandoski M., Sun X., Martin G. Fgf8 signalling from the AER is essential for normal limb development. Nat. Genet. 26:2000;460-463.
6. Moon A., Capecchi M. Fgf8 is required for outgrowth and patterning of the limbs. Nat. Genet. 26:2000;455-459.
7. Martinez S., Crossley P., Cobos I., Rubenstein J., Martin G. FGF8 induces formation of an ectopic isthmic organiser and isthmocerebellar development via a repressive effect on Otx2 expression. Development. 126:1999;1189-1200.
8. Phillips B., Bolding K., Riley B. Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction. Dev. Biol. 235:2001;351-365.
9. Maroon H., Walshe J., Mahmood R., Kiefer P., Dickson C., Mason I. Fgf3 and Fgf8 are required for otic development. Development. 129:2002;2099-2108.
10. Ornitz D.M. FGFs, heparin sulfate and FGFRs: complex interactions essential for development. BioEssays. 22:2000;108-112.
11. Deng C.X., Wynshawboris A., Shen M.M., Daugherty C., Ornitz D.M., Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organisation. Genes Dev. 8:1994;3045-3057.
12. Yamaguchi T.P., Harpal K., Henkemeyer M., Rossant J. Fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 8:1994;3032-3044.
13. Arman E., Haffner-Krausz R., Chen Y., Heath J., Lonai P. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signalling in pregastrulation mammalian development. Proc. Natl. Acad. Sci. U. S. A. 95:1998;5082-5087.
14. Schlessinger J. Cell signalling by receptor tyrosine kinases. Cell. 103:2000;211-225.
15. Pearson G., Robinson F., Beers-Gibson T., Xu B., Karandikar M., Berman K., Cobb M. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22:2001;153-183.
16. Tickle C. Patterning systems - from one end of the limb to the other. Dev. Cell. 4:2003;449-458.
17. Capdevila J., Izpisua-Belmonte J. Patterning mechanisms controlling vertebrate limb development. Annu. Rev. Cell Dev. Biol. 17:2001;87-132.
18. Consortium I.H.G.S. Initial sequencing and analysis of the human genome. Nature. 409:2001;860-921.
19. Skarnes W.C., Auerbach B.A., Joyner A.L. A gene trap approach in mouse embryonic stem cells: the lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev. 6:1992;903-918.
20. Stanford W., Cohn J., Cordes S. Gene-trap mutagenesis: past, present and beyond. Nat. Genet. Rev. 2:2001;756-768.
21. Kluppel M., Vallis K., Wrana J. A high-throughput induction gene trap approach defines C4ST as a target of BMP signalling. Mech. Dev. 118:2002;77-89.
22. Ramirez-Solis R., Davis A.C., Bradley A. Gene targeting in embryonic stem cells. Wassarman P.M., DePamphilis M.L. Guide to Techniques in Mouse Development. 1993;855-878 Academic Press, San Diego.
23. Whiting J., Marshall H., Cook M., Krumlauf R., Rigby P.W.J., Stott D., Allemann R.K. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 5:1991;5383-5396.
24. Eustice D.C., Feldman P.A., Colberg-Poley A.M., Buckery R.M., Neubauer R.H. A sensitive method for the detection of β-galactosidase in transfected mammalian cells. BioTechniques. 11:1991;739-742.
25. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, New York.
26. Nonchev S., Maconochie M. Spatial analysis of gene expression. Jackson I.J., Abbott A.C. Genetics and Transgenics: A Practical Approach. 1999;61-86 Oxford Univ. Press, New York.
27. De Moerlooze L., Dickson C. Skeletal disorders associated with fibroblast growth factor receptor mutations. Curr. Opin. Genet. Dev. 7:1997;378-385.
28. Talarmin H., Rescan C., Cariou S., Glaise D., Zanninelli G., Bilodeau M., Loyer P., Guguen-Guillouzo C., Baffet G. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol. Cell. Biol. 19:1999;6003-6011.
29. Traverse S., Gomez N., Paterson H., Marshall C., Cohen P. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288:1992;351-355.
30. Donohue P.J., Alberts G.F., Guo Y.W., Winkles J.A. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J. Biol. Chem. 270:1995;10351-10357.
31. McDonald F.J., Heath J.K. Developmentally regulated expression of fibroblast growth factor receptor genes and splice variants by murine embryonic stem and embryonal carcinoma cells. Dev. Genet. 15:1994;148-154.
32. Bogoyevititch M., Glennon P., Andersson M., Clerk A., Lazou A., Marshall C., Parker P., Sugden P. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signalling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signalling pathways leading to myocyte hypertrophy. J. Biol. Chem. 269:1994;1110-1119.
33. Bouche G., Baldin V., Belenguer P., Prats H., Amalric F. Activation of rDNA by FGF-2: key role of protein kinase CKII. Cell. Mol. Biol. Res. 40:1994;547-554.
34. Hunter P., Swanson B., Haendel M., Lyons G., Cross J. Mrj encodes a DNAJ-related co-chaperone that is essential for murine placental development. Development. 126:1999;1247-1258.
35. Friesel R.E., Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 9:1995;919-925.
36. Sanjay A., Fu J., Krieibich G. DAD1 is required for the function and structural integrity of the oligosaccharide complex. J. Biol. Chem. 273:1998;26094-26099.
37. Nakashima T., Sekiguchi T., Kuraoka A., Fukushima K., Shibata Y., Komiyama S., Nishimoto T. Molecular cloning of a human cDNA encoding a novel protein DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol. Cell. Biol. 13:1993;6367-6374.
38. Fu J., Kreibich G. Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. J. Biol. Chem. 275:2000;3890-3984.
39. Wang L.-H., Strittmatter S. A family of rat CRMP genes is differentially expressed in the nervous system. J. Neurosci. 16:1996;6197-6207.
40. Szebenyi G., Dent E., Callaway J., Seys C., Lueth H., Kalil K. Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behaviour of the primary growth cone. J. Neurosci. 21:2001;3932-3941.
41. Mansour S.L., Goddard J.M., Capecchi M.R. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 117:1993;13-28.
42. Wright T.J., Mansour S.L. Fgf3 and Fgf10 are required for mouse optic placode induction. Development. 130:2003;3379-3390.